Phase coupling between rhythmic slow activity and gamma characterizes mesiotemporal rapid-eye-movement sleep in humans

Clemens, Zsófia; Weiss, Béla; Szücs, Anna; Erőss, Lóránd; Rásonyi, György; Halász, Péter

doi:10.1016/j.neuroscience.2009.06.044

Cited by 41 publications

(49 citation statements)

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“…Altogether navigation-related increase in mesiotemporal delta activity affected similar frequency bins as did REM sleep in our previous studies with FO electrodes (Bódizs et al, 2001a;Clemens et al, 2009). Although as compared with REM sleep, navigation-related delta appeared to be less salient and organized and did neither consistently resulted in a lowfrequency spectral peak in all navigation conditions and patients.…”

Section: Discussionsupporting

confidence: 62%

“…Regarding the affected frequencies our data closely resembles those in the study by Lega et al (2011) reporting predominating hippocampal oscillations at ~3 and ~8 Hz with the former positively while the latter negatively correlating with successful episodic memory encoding. In the present study we found highest task-related power increases in the 1 Hz frequency bin thus of somewhat lower frequency than the 1.5-3 Hz range that we previously found for REM sleep (Bódizs et al, 2001;Clemens et al, 2009). However here we did not analyze REM sleep so we cannot exactly determine how task-related and REM-related slow activity increases are linked within the same patient.…”

Section: Discussioncontrasting

confidence: 53%

“…Thus, to avoid redundancy we report here, as in our previous studies (Clemens et al, 2007(Clemens et al, , 2009(Clemens et al, , 2011 analyses performed on the two anterior channels (FO4 and FO8). In one patient posterior channels (FO1 and FO5) were used because of strong artefacts in the other ones.…”

Section: Resultsmentioning

confidence: 99%

“…A few studies used bipolar montage while others do not report whether bipolar or monopolar montage was used. Since RSA is highly synchronous across neighboring mesiotemporal contacts slow oscillation cycles are extinguished when using bipolar derivation (Bódizs et al, 2001a,b;Clemens et al, 2009). Third, the majority of studies used recordings from the scalp or various neocortical sites but only three studies looked directly at the hippocampus during virtual navigation tasks.…”

Section: Discussionmentioning

confidence: 99%

“…In a recent study we demonstrated a phase-coupling of high-frequency activity with the 1.5-3 Hz mesiotemporal delta oscillations during REM sleep (Clemens et al, 2009). Such a phase coupling closely resembles that seen between theta and gamma in animals.…”

Section: Introductionmentioning

confidence: 90%

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Increased mesiotemporal delta activity characterizes virtual navigation in humans

Clemens

Borbély

Weiss

et al. 2013

Neuroscience Research

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Hippocampal theta or rhythmic slow activity (RSA) occurring during exploratory behaviors and rapid-eye-movement (REM) sleep is a characteristic and well-identifiable oscillatory rhythm in animals. In contrast, controversy surrounds the existence and electrophysiological correlates of this activity in humans. Some argue that the human hippocampal theta occurs in short and phasic bursts. On the contrary, our earlier studies provide evidence that REM-dependent mesiotemporal RSA is continuous like in animals but instead of the theta it falls in the delta frequency range. Here we used a virtual navigation task in 24 epilepsy patients implanted with foramen ovale electrodes. EEG was analyzed for 1-Hz wide frequency bins up to 10 Hz according to four conditions: resting, non-learning route-following, acquisition and recall. We found progressively increasing spectral power in frequency bins up the 4 Hz across these conditions. No spectral power increase relative to resting was revealed within the traditional theta band and above in any of the navigation conditions. Thus the affected frequency bins were below the theta band and were similar to those characterizing REM sleep in our previous studies providing further indication that it is delta rather than theta that should be regarded as a human analogue of the animal RSA.NeuroscienceResearch, Volume 76, Issues 1-2, May-June 2013, Pages 67-75, DOI: 10.1016/j.neures.2013.03.004 HighlightsMesiotemporal EEG activity was assessed during a spatial task in epilepsy patients.Low frequency spectral power increased during all three navigation conditions.There was no change during task performance in the theta frequency band.Delta rather than theta should be regarded as a human analogue of animal theta. *Highlights (for review) Click here to download Highlights (for review): highlights.doc 2 AbstractHippocampal theta or rhythmic slow activity (RSA) occurring during exploratory behaviors and rapid-eye-movement (REM) sleep is a characteristic and well-identifiable oscillatory rhythm in animals. In contrast, controversy surrounds the existence and electrophysiological correlates of this activity in humans. Some argue that the human hippocampal theta occurs in short and phasic bursts. On the contrary, our earlier studies provide evidence that REMdependent mesiotemporal RSA is continuous like in animals but instead of the theta it falls in the delta frequency range. Here we used a virtual navigation task in 24 epilepsy patients implanted with foramen ovale electrodes. EEG was analyzed for 1-Hz wide frequency bins up to 10 Hz according to four conditions: resting, non-learning route-following, acquisition and recall. We found progressively increasing spectral power in frequency bins up the 4 Hz across these conditions. No spectral power increase relative to resting was revealed within the traditional theta band and above in any of the navigation conditions. Thus the affected frequency bins were below the theta band and were similar to those characterizing REM sleep in our previ...

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Section: Discussionsupporting

confidence: 62%

Section: Discussioncontrasting

confidence: 53%

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 90%

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Increased mesiotemporal delta activity characterizes virtual navigation in humans

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Borbély

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Solid‐phase synthesis for a lifetime

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2008

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Dynamics of hippocampus and orbitofrontal cortex activity during arousing reactions from sleep: An intracranial electroencephalographic study

Ruby

Eskinazi

Bouet

et al. 2021

Human Brain Mapping

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Sleep is punctuated by transient elevations of vigilance level called arousals or awakenings depending on their durations. Understanding the dynamics of brain activity modifications during these transitional phases could help to better understand the changes in cognitive functions according to vigilance states. In this study, we investigated the activity of memory‐related areas (hippocampus and orbitofrontal cortex) during short (3 s to 2 min) arousing reactions detected from thalamic activity, using intracranial recordings in four drug‐resistant epilepsy patients. The average power of the signal between 0.5 and 128 Hz was compared across four time windows: 10 s of preceding sleep, the first part and the end of the arousal/awakening, and 10 s of wakefulness. We observed that (a) in most frequency bands, the spectral power during hippocampal arousal/awakenings is intermediate between wakefulness and sleep whereas frontal cortex shows an early increase in low and fast activities during non‐rapid‐eye‐movement (NREM) sleep arousals/awakenings; (b) this pattern depends on the preceding sleep stage with fewer modifications for REM than for non‐REM sleep arousal/awakenings, potentially reflecting the EEG similarities between REM sleep and wakefulness; (c) a greater activation at the arousing reaction onset in the prefrontal cortex predicts longer arousals/awakenings. Our findings suggest that hippocampus and prefrontal arousals/awakenings are progressive phenomena modulated by sleep stage, and, in the neocortex, by the intensity of the early activation. This pattern of activity could underlie the link between sleep stage, arousal/awakening duration and restoration of memory abilities including dream recall.

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Phase coupling between rhythmic slow activity and gamma characterizes mesiotemporal rapid-eye-movement sleep in humans

Cited by 41 publications

References 41 publications

Increased mesiotemporal delta activity characterizes virtual navigation in humans

Increased mesiotemporal delta activity characterizes virtual navigation in humans

Solid‐phase synthesis for a lifetime

Dynamics of hippocampus and orbitofrontal cortex activity during arousing reactions from sleep: An intracranial electroencephalographic study

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