Phase Detection of the Two-Port FPW Sensor for Biosensing

Abstract

This study reports the phase detection of the two-port flexural plate wave (FPW) sensor for designing and integrating the miniature system and provides a comprehensive methodology for portable using in the biosensor applications of severe acute respiratory syndrome coronavirus (SARS-CoV). The miniature system mainly utilizes the concept of the frequency divider that involves a divider, a time-based oscillator and a gate to reduce the high frequency, and the FPW sensor is fabricated using microelectromechanical systems (MEMS) technologies for producing a potable biosensing detector. The results demonstrate that the insertion loss decreased about 1 15% dB/ C, and the phase delay was about 2.05 /(1000 cP). The phaseshift resolution was about 10 mV per degree, and the original frequency of 4.2 MHz was divided by 100 to reduce the frequency to 42 kHz. The SARS-CoV could be detected via the S protein binds to the human angiotensin-converting enzyme 2 (hACE2) as a functional receptor, which would cause the phase delay due to the combining of the antibody with the antigen. Therefore, the feasibility studies provide the information that phase detection is an appropriate low-cost technology via frequency divider for fabricating of the miniature biosensors.Index Terms-Biosensing, flexural plate wave, integrated system, phase detection, readout concept, severe acute respiratory syndrome coronavirus (SARS-CoV).

Scalable hybrid microelectronic-microfluidic integration of highly sensitive biosensors

“…It was assembled after the process presented further down. The insertion loss at resonance reads -18 dB and is comparable with literature values and the reference measurement [11]. The signal to noise ratio reads +40 dB and thus the integration is considered successful.…”

“…Layout of one FPW-sensor Spectrum of the FPW sensor after integration into a microelectronic package.IMAPS 2018 -51st International Symposium on Microelectronics -Pasadena, CA USA -Oct [8][9][10][11]. 2018 Visit www.imapsource.org for more IMAPS papers (Left) Luer connector for fluid connection between the syringe adapters and the microfluidic of the package.…”

Nanotribology of self-assembled monolayer with a probe tip investigated using molecular dynamics simulations

“…Self-assembled monolayers (SAMs) have been applied in biological (Mrksich, 2009;Matsunaga et al, 2007;Chang et al, 2008), physical (Henry et al, 2006), optical Li, 2009), and chemical (Bowen et al, 2008) sensors. SAMs have proven to be effective nano-lubricants in nano/microelectromechanical systems (N/MEMS) and in nanoimprinting lithography (NIL) (Guo, 2004;Kohno et al, 2010) helping to avoid failure during the operation of these devices (Maboudian et al, 2000;Tambe and Bhushan, 2005).…”

A Novel Analog Autocalibrating Phase-Voltage Converter for Signal Phase-Shifting Detection

“…However, these circuits do not measure the signal phase shift and require a power-on manual calibration procedure, avoiding their use in remote sensor networks which need front-end circuits operating in an autocalibrating mode (i.e., Plug & Play wireless sensor systems). For these purposes, in order to perform a phase-voltage conversion [28]- [35], we have designed and developed, on a breadboard with low-cost discrete commercial components, a simple autocalibrating circuit suitable for phase-shift detection in sensor interfacing and signal processing. In particular, we have implemented an analog electronic system which allows to detect the relative phase variation between input and reference signals having the same frequency and converting it into a dc voltage signal.…”