Phase equilibrium and mechanisms of crystallization in liquid–liquid phase separating system

Yang, Huaiyu; Rasmuson, Åke C.

doi:10.1016/j.fluid.2014.11.007

Cited by 33 publications

(40 citation statements)

References 41 publications

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“…A similar phase behavior was found for a much less complicated aqueous ternary system of butyl paraben in a mixture of water and ethanol, which has a phase diagram that resembles the lignin solubility map in this work . Four solubility regions [one phase, liquid–liquid equilibrium (LLE), solid–liquid equilibrium (SLE), and solid–liquid–liquid equilibrium (SLLE)] were also observed in the work of Yang and Rasmuson at room temperature. Thus, it can be concluded that the monomeric unit of lignin, which resembles that of butyl paraben, behaves in a similar manner in the water–organic solvent mixture.…”

Section: Resultssupporting

confidence: 81%

“…Both the formation of an emulsion and the liquid–liquid phase split prevent the precipitation of the undissolved lignin. However, the presence of the second phase can be useful for controlling the growth of lignin agglomerates and surface properties of the lignin particles. The low molecular weight lignin can be formed in the organosolv process, and its surface properties vary depending on the presence of the second liquid phase.…”

Section: Resultsmentioning

confidence: 99%

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Solubility of Organosolv Lignin in γ‐Valerolactone/Water Binary Mixtures

et al. 2016

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The solubility of lignin in a mixture of γ-valerolactone (GVL) and water at different weight ratios was measured using the Hildebrand solubility parameters. Based on the molecular structure of lignin, its solubility parameter (δ-value) was calculated as 25.5 MPa . The δ-value for aqueous GVL solvent increased from 23.1 MPa for pure GVL to 45.6 MPa for pure water. Therefore, the lignin solubility was predicted to increase with increasing GVL concentration in the aqueous mixture up to approximately 92-96 wt % of GVL. A ternary diagram describing the phase behavior of water-GVL-lignin mixtures at room temperature was constructed based on the experimental results. The three-component system exhibited a complex behavior with a liquid-liquid and solid-liquid-liquid phase split. The efficiency of the selected fractionation trials in a previous work was validated using the ternary solubility diagram. A promising recovery pathway and lignin isolation method were deduced from the results of this work.

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Section: Resultssupporting

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Solubility of Organosolv Lignin in γ‐Valerolactone/Water Binary Mixtures

et al. 2016

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“…Parabens crystals grown from the same organic solvent (ethanol, ethyl acetate, or acetone) had similar morphology Figure 9 FBRM curves of Exp .1 to Exp. 3 with in-situ PVM photos in cooling crystallization process and off-line microscope images of product crystals [61][62]76] which were consistent with computational simulation using BFDH method [85]. The solvent effect on the crystal interfacial energy was strong, while the crystal morphology change caused by solvent is not so obvious.…”

Section: Crystal Structures and Polymorphismsupporting

confidence: 77%

Review on Life Cycle of Parabens: Synthesis, Degradation, Characterization and Safety Analysis

Yang

Zhang

2018

COC

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In this review, we show the life cycle of parabens, commonly used preservatives that exist in nature and commercial products. Typical synthetic methods to produce parabens, and a set of complimentary characterization techniques to monitor the composition of parabens are also highlighted. These includes solid state analysis using Scanning Electron Microscope (SEM), Differential Scanning Calorimetry (DSC) and X-Ray Diffraction (XRD), in-situ monitoring of crystallization process using Focused Beam Reflectance Measurement (FBRM), Particle Vision Measurement (PVM), quantitative detection via High Performance Liquid Chromatography (HPLC), and Gas Chromatography (GC). An improved understanding of the overall physical, biophysical and chemical properties of parabens and their life cycle, summarized in this article, are vital for the safety control and extensive applications of relevant products in food, cosmetic and pharmaceutical industries.

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“…4 Polymorphic purity is essential for quality control, as the presence of any undesirable polymorphs or polymorphic transformation during manufacturing processes induces substantial economic loss (for example, more than $250 million loss due to an unknown more stable form of ritonavir, an antiviral compound for AIDS). 5 The evaporation crystallisation processes of butyl paraben in liquid-liquid phase separation are very different on glass, metal and PTFE surfaces, 6,7 and ibuprofen changes morphology on Al, Au or self-assembled -CH 3 , -OH, and -COOH monolayers. 8 On a siloxane monolayer template, a metastable polymorph of 1,3-bisĲm-nitrophenyl)urea appeared.…”

Section: Introductionmentioning

confidence: 99%

Selective crystallisation of carbamazepine polymorphs on surfaces with differing properties

et al. 2017

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Surface-induced nucleation of carbamazepine (CBZ) in ethanol was investigated with different surface materials: glass, polytetrafluoroethylene (PTFE) and tin. The introduction of foreign surfaces with different areas and surface chemistries into the solution has an impact on the crystal morphology and polymorphic form (Form II or III). With an increase in supersaturation, a higher possibility of crystallisation of CBZ metastable Form II was observed, as expected. Increasing the number of inserts resulted in a direct increase in the surface area available for heterogeneous nucleation. The increase in surface area resulted in the greater possibility of obtaining the metastable Form II of CBZ. The stable Form III preferred to nucleate on tin rather than on glass and PTFE. The results indicate that the two different polymorphs of CBZ can be selectively crystallised out from solution with the aid of a foreign surface. The kinetic mechanism of heterogeneous nucleation of the different polymorphs induced by foreign surfaces was discussed. The potential applications will be used to control and design the crystallisation process.

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Phase equilibrium and mechanisms of crystallization in liquid–liquid phase separating system

Cited by 33 publications

References 41 publications

Solubility of Organosolv Lignin in γ‐Valerolactone/Water Binary Mixtures

Solubility of Organosolv Lignin in γ‐Valerolactone/Water Binary Mixtures

Review on Life Cycle of Parabens: Synthesis, Degradation, Characterization and Safety Analysis

Selective crystallisation of carbamazepine polymorphs on surfaces with differing properties

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