Phase I/II Study of Stage III and IV Non-Small Cell Lung Cancer Patients Taking a Specific Dietary Supplement

Sun, Alexander S.; Ostádal, O; Ryznar, Vaclav; Dulik, Ivan; Dusek, J; Václavík, A; Yeh, Hsu-Chong; Hsu, Ching Min; Bruckner, Howard W.; Fasy, Thomas M.

doi:10.1207/s15327914nc340109

Cited by 26 publications

(15 citation statements)

References 34 publications

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“…Two small studies sought to determine whether dietary intervention with selected vegetables improved survival among those with Stage III or IV non-small-cell lung cancer. 122,123 Weight loss was less and survival was longer in the intervention groups in those studies. Although these results are encouraging, these findings need to be confirmed by other investigators and in larger studies.…”

Section: Lung Cancermentioning

confidence: 88%

Nutrition and Physical Activity During and After Cancer Treatment: An American Cancer Society Guide for Informed Choices

Brown

Byers

Doyle

et al. 2003

CA: A Cancer Journal for Clinicians

277

202

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Cancer survivors are often highly motivated to seek information about food choices, physical activity, dietary supplement use, and complementary nutritional therapies to improve their treatment outcomes, quality of life, and survival. To address these concerns, the American Cancer Society (ACS) convened a group of experts in nutrition, physical activity, and cancer to evaluate the scientific evidence and best clinical practices related to optimal nutrition and physical activity after the diagnosis of cancer. This report summarizes their findings and is intended to present health care providers with the best possible information on which to help cancer survivors and their families make informed choices related to nutrition and physical activity. The report discusses nutrition and physical activity issues during the phases of cancer treatment and recovery, living after recovery from treatment, and living with advanced cancer; selected nutritional and physical activity issues such as body weight, food choices, and complementary and alternative nutritional options; and selected issues related to breast, colorectal, lung, prostate, head and neck, and upper gastrointestinal cancers. In addition, handouts containing commonly asked questions and answers and a resource list are provided for survivors and families. Tables that grade the scientific evidence for benefit versus harm related to nutrition and physical activity for breast, colorectal, lung, and prostate cancers are also included for this growing body of knowledge to provide guidance for informed decision making and to identify areas for future research. (CA Cancer J Clin 2003;53:268 -291.)

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Section: Lung Cancermentioning

confidence: 88%

Nutrition and Physical Activity During and After Cancer Treatment: An American Cancer Society Guide for Informed Choices

Brown

Byers

Doyle

et al. 2003

CA: A Cancer Journal for Clinicians

277

202

View full text Add to dashboard Cite

show abstract

“…A dietary supplementation of vegetable soup preparation given in clinical trials with patients having stage III and IV non-small cell lung cancer was reported (20, 21). The diets, which contain vegetables and fruits with multiple functional components have no side-effects, and believed to be effective for prevention of cancer and inflammation.…”

Section: Discussionmentioning

confidence: 99%

Immunostimulation‐Mediated Anti‐Tumor Activity of Bamboo (Sasa senanensis) Leaf Extracts Obtained under ‘Vigorous’ Condition

Seki

Kida

Maeda

2008

Evidence-Based Complementary and Alternative Medicine

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Traditional Japanese medicine uses the leaves of Kumaizasa bamboo extracted in hot water at 100°C. For this study, we developed a new, ‘vigorous’ extraction method involving steps at 100, 121 and 196°C. This procedure not only yielded greater amounts of extract but also with significant increase in immunostimulating activity, which induces activation of human natural killer (NK) cells, macrophages and potent induction of IL-2, IL-12 and IFN-γ in tumor bearing mice. The efficacy of the extract to facilitate phagocytosis and nitric oxide production by mouse peritoneal macrophages was determined and compared with that of 1,3-β-glucan. Anti-tumor activity was evaluated in vivo in several mouse tumor models (S-180, C38 and Meth-A). Oral administration of the extracts was carried out when tumor reached size of approximately 6 mm at concentrations of 0.05% or higher. The extracts significantly suppressed tumor growth in S-180 and C38 tumor models. Overall survival was significantly prolonged in the treatment group than that of control. Activation of macrophages and NK cells by the extracts suggests that the anti-tumor efficacy of the extract is mediated by immunopotentiation. The extracts resolved into three major fractions (F-I, F-II and F-III) in Sephadex gel chromatography. Fraction F-I consists of 1,3-β-glucan and stimulated both macrophages and NK cells suggesting that it may be the primary immunopotentiating factor in suppressing cancer. Fraction F-III has potent free radical scavenging effects and may play an important role in cancer prevention. These results warrant further translation and clinical investigations.

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“…The median survival of control patients was 4 months (mean 4.8 months), while that of patients who received the vegetable remedy was 15.5 months (mean 15 months). This non-toxic vegetable brew was also reported to improve quality of life [39].…”

mentioning

confidence: 95%

Herbs and Other Botanicals in Cancer Patient Care

Cassileth

Yeung

Gubili

2008

Curr. Treat. Options in Oncol.

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Non-prescription herbal remedies are commonly used by cancer patients in efforts to control their disease or to manage symptoms associated with cancer and cancer treatments. We address the issues surrounding the use of herbs, herbal compounds, and other botanical agents in the oncology context. Botanicals are biologically active agents that can be useful under appropriate circumstances, but they may be counterproductive when used by patients on chemotherapy or on other prescription medications. Herbs and other botanical agents, despite common public belief, are not benign. They should be understood as unrefined pharmaceuticals, with the capacity to produce physiologic change for better or worse. Indeed, many prescription drugs, chemotherapeutic agents among them, were derived from plants and other natural agents, and the search for additional constituents of plants, animals, and minerals for use as pharmaceutical agents remains an active effort on many fronts. Cautions, appropriate application, and potential utility of botanical agents are discussed below, and sources of reliable information are provided.

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Phase I/II Study of Stage III and IV Non-Small Cell Lung Cancer Patients Taking a Specific Dietary Supplement

Cited by 26 publications

References 34 publications

Nutrition and Physical Activity During and After Cancer Treatment: An American Cancer Society Guide for Informed Choices

Nutrition and Physical Activity During and After Cancer Treatment: An American Cancer Society Guide for Informed Choices

Immunostimulation‐Mediated Anti‐Tumor Activity of Bamboo (Sasa senanensis) Leaf Extracts Obtained under ‘Vigorous’ Condition

Herbs and Other Botanicals in Cancer Patient Care

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