Phase I/II Trial of Chemotherapy with Docetaxel, Cisplatin, and S-1 for Unresectable Advanced Squamous Cell Carcinoma of the Esophagus

Ojima, Toshiyasu; Nakamura, Masaki; Nakamori, Mikihito; Katsuda, Masahiro; Hayata, Keiji; Maruoka, Shimpei; Shimokawa, Toshio; Yamaue, Hiroki

doi:10.1159/000488861

Cited by 3 publications

(1 citation statement)

References 19 publications

(16 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Chemotherapy is most used as the primary treatment modality for a select number of different types of cancer, as palliative treatment for specific types of advanced tumours, and as an adjuvant treatment before, during, or after local treatment (surgery and/or radiotherapy). The elimination of metastases and an improvement in the management of local tumours are the goals of chemotherapy (Dasari and Tchounwou, 2014;Ojima et al, 2018). Yet, chemotherapy can also have a cytotoxic effect on healthy cells and tissues in addition to the cells it targets in cancerous ones.…”

Section: Introductionmentioning

confidence: 99%

A Comparative Histological and Immunohistochemical Study on the Effect of Moringa Oil and Sesame Oil on the Submandibular Glands of Cisplatin Treated Albino Rats.

El-Messiry

Shaer

Fathy

2023

Egyptian Dental Journal

View full text Add to dashboard Cite

Cisplatin, also known as CP, is an antineoplastic drug that is utilised most frequently in the chemotherapeutic treatment of a wide variety of cancers. Because of the high levels of monounsaturated fatty acids, sterols, tocopherols, and proteins that are rich in sulfated amino acids that are found in Moringa oleifera oil (MO) and Sesame oil (SO) seeds, these two plant species have the potential to become valuable resources. A comparison of the protective effects of MO and SO against the damage caused by CP in the submandibular glands of albino rats was the purpose of this study. 45 rats were randomly assigned to one of four groups: group I served as the control, group II received a single intraperitoneal injection of CP (5 mg/kg), group III received MO (5mg/ kg/day) orally, and group IV received SO (5mg/kg/day) orally. Histopathological changes such as cytoplasmic vacuolation, irregular dark shrunken nuclei, loss of normal acinar architecture, irregular and distorted ducts with focal loss of their lining epithelium and basement membrane, and congested blood vessels were observed in the CP group. These changes were observed in the pancreatic polyps. In the CP group, we saw large increases in the expression of -SMA and Caspase-3, and significant decreases in the expression of PCNA and PAS. These findings showed some sign of improvement in the groups that had been treated with MO and SO. According to the findings of this investigation, both MO and SO were able to mitigate the harm produced by cisplatin, with MO showing a very tiny advantage over SO.

show abstract

Section: Introductionmentioning

confidence: 99%

A Comparative Histological and Immunohistochemical Study on the Effect of Moringa Oil and Sesame Oil on the Submandibular Glands of Cisplatin Treated Albino Rats.

El-Messiry

Shaer

Fathy

2023

Egyptian Dental Journal

View full text Add to dashboard Cite

show abstract

Triplet chemotherapy with docetaxel, cisplatin and S-1 for unresectable advanced squamous cell carcinoma of the esophagus: phase I/II trial results

et al. 2019

Self Cite

View full text Add to dashboard Cite

BackgroundAlthough triplet regimen of docetaxel, cisplatin, and 5-FU (DCF) reportedly yields high response rates for metastatic squamous cell carcinoma of the esophagus (SCCE), it has severe toxicity. In our previous phase II trial, grade 3/4 toxicities of neutropenia occurred in 68.8% of the patients. Development of chemotherapeutic regimen that does not impair quality of life of the patients with metastatic SCCE is therefore needed. A novel chemotherapeutic regimen combining docetaxel, cisplatin, and alternate-day administration of S-1 (modified DCS) may be associated with reduction of severe adverse effects.MethodsThis study is a single center phase I/II trial of chemotherapy using modified DCS regimen for patients with recurrent/unresectable SCCE. The phase I trial adopts a ‘3 + 3 patient cohort’, dose-escalating study design. In the phase II trial, the primary endpoint is evaluation of the overall response rate (ORR). Secondary endpoints are evaluation of drug-related toxicity, overall survival (OS), and progression-free survival (PFS).ResultsIn the phase I trial, the recommended dose for docetaxel, cisplatin, and S-1 were 40 mg/m2 (day 1), 50 mg/m2 (day 1), and 80 mg/m2/day, respectively. In the phase II trial (n = 50), the ORR was 54 %. The median OS and PFS were 10 and 4 months, respectively. Grade 3/4 adverse events included neutropenia (26%), leukopenia (14%), anorexia (10%) and febrile neutropenia (6%).ConclusionThe modified DCS therapy for patients with advanced SCCE is feasible and safe in both chemotherapeutic and perioperative periods.Registration number: UMIN000016364.

show abstract

Ameliorative Effect of Sesamin in Cisplatin-Induced Nephrotoxicity in Rats by Suppressing Inflammation, Oxidative/Nitrosative Stress, and Cellular Damage

et al. 2020

View full text Add to dashboard Cite

Nephrotoxicity of cisplatin (CP) involves renal oxidative stress and inflammation, and sesamin (a major liganin in many plants) has strong antioxidant and antiinflammatory actions. Therefore, we investigated here the possible mitigative action of sesamin on CP nephrotoxicity in rats. Sesamin was given orally (5 mg/kg/day, 10 days), and on the 7th day, some of the treated rats were injected intraperitoneally with either saline or CP (5 mg/kg). On the 11th day, rats were sacrificed, and blood and urine samples and kidneys were collected for biochemical estimation of several traditional and novel indices of renal damage in plasma and urine, several oxidative and nitrosative indices in kidneys, and assessment of histopathological renal damage. CP significantly and adversely altered all the physiological, biochemical and histopathological indices of renal function measured. Kidneys of CP‐treated rats had a moderate degree of necrosis. This was markedly lessened when CP was given simultaneously with sesamin. Sesamin treatment did not significantly alter the renal CP concentration. The results suggested that sesamin had ameliorated CP nephrotoxicity in rats by reversing the CP-induced oxidative stress and inflammation. Pending further pharmacological and toxicological studies sesamin may be considered a potentially useful nephroprotective agent.

show abstract

Phase I/II Trial of Chemotherapy with Docetaxel, Cisplatin, and S-1 for Unresectable Advanced Squamous Cell Carcinoma of the Esophagus

Cited by 3 publications

References 19 publications

A Comparative Histological and Immunohistochemical Study on the Effect of Moringa Oil and Sesame Oil on the Submandibular Glands of Cisplatin Treated Albino Rats.

A Comparative Histological and Immunohistochemical Study on the Effect of Moringa Oil and Sesame Oil on the Submandibular Glands of Cisplatin Treated Albino Rats.

Triplet chemotherapy with docetaxel, cisplatin and S-1 for unresectable advanced squamous cell carcinoma of the esophagus: phase I/II trial results

Ameliorative Effect of Sesamin in Cisplatin-Induced Nephrotoxicity in Rats by Suppressing Inflammation, Oxidative/Nitrosative Stress, and Cellular Damage

Contact Info

Product

Resources

About