Phase I study of intraoperative radiotherapy with photon radiosurgery system in children with recurrent brain tumors: Preliminary report of first dose level (10 Gy)

Kalapurakal, John A.; Goldman, Stewart; Stellpflug, Wendy; Curran, John; Sathiaseelan, V.; Marymont, Maryanne Hoffman; Tomita, Tadanori

doi:10.1016/j.ijrobp.2006.01.006

Cited by 27 publications

(19 citation statements)

References 30 publications

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“…Of 14 patients (13 diagnosed with recurrent ependymoma), 8 (57%) showed local tumor control after surgical resection and intraoperative radiotherapy. 158 With the development of these new radiation techniques, the effect on cognition and development might be reduced and therefore become a valid part in the treatment of these patients, independent of age.…”

Section: Radiation Therapymentioning

confidence: 99%

Pediatric Brain Tumors: Current Treatment Strategies and Future Therapeutic Approaches

2009

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Summary:Pediatric CNS tumors are the most common solid tumors of childhood and the second most common cancer after hematological malignancies accounting for approximate 20 to 25% of all primary pediatric tumors. With over 3,000 new cases per year in the United States, childhood CNS tumors are the leading cause of death related to cancer in this population. The prognosis for these patients has improved over the last few decades, but current therapies continue to carry a high risk of significant side effects, especially for the very young. Currently a combination of surgery, radiation, and chemotherapy is often used in children greater than 3 years of age. This article will outline current and future therapeutic strategies for the most common pediatric CNS tumors, including primitive neuroectodermal tumors such as medulloblastoma, as well as astrocytomas and ependymomas.

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Section: Radiation Therapymentioning

confidence: 99%

Pediatric Brain Tumors: Current Treatment Strategies and Future Therapeutic Approaches

2009

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“…Intraoperative radiotherapy, using an innovative miniature x-ray source avoids unnecessary treatment to the whole breast and delivers a critical dose to the tumour bed only. It has also been shown to be effective in the treatment of intracranial malignancies [10-12]. Ninewells Hospital currently uses the Photon Radiosurgery System (PRS – Carl Zeiss Surgical GmbH, Oberkochen, Germany) to treat breast and neurological tumours.…”

Section: Introductionmentioning

confidence: 99%

Functional intercomparison of intraoperative radiotherapy equipment – Photon Radiosurgery System

et al. 2007

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Background: Intraoperative Radiotherapy (IORT) is a method by which a critical radiation dose is delivered to the tumour bed immediately after surgical excision. It is being investigated whether a single high dose of radiation will impart the same clinical benefit as a standard course of external beam therapy. Our centre has four Photon Radiosurgery Systems (PRS) currently used to irradiate breast and neurological sites.

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“…IORT was performed with electron beams or lowenergy X-rays using dedicated equipments [9,21,29,34]. Both modalities proved to be feasible and led to limited toxicity, but with no clear evidence of clinical benefit, even because of the small number of patients included in each study.…”

Section: Discussionmentioning

confidence: 99%

Perioperative High-Dose-Rate Brachytherapy in the Treatment of Recurrent Malignant Gliomas

Fabrini

Perrone²,

Franco³

et al. 2009

Strahlenther Onkol

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Phase I study of intraoperative radiotherapy with photon radiosurgery system in children with recurrent brain tumors: Preliminary report of first dose level (10 Gy)

Cited by 27 publications

References 30 publications

Pediatric Brain Tumors: Current Treatment Strategies and Future Therapeutic Approaches

Pediatric Brain Tumors: Current Treatment Strategies and Future Therapeutic Approaches

Functional intercomparison of intraoperative radiotherapy equipment – Photon Radiosurgery System

Perioperative High-Dose-Rate Brachytherapy in the Treatment of Recurrent Malignant Gliomas

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