“…This suggests that Ad5/3-Cox2L-D24, at the doses used here, did not induce acute systemic toxicity responses. 23,30 As proposed in previous investigations, [31][32][33] we analyzed Ad5/3-Cox2L-D24 genome copy number in the serum as a surrogate for viral replication. We found virus in the serum of 13 out of 17 patients at least once 2 days or later post treatment, and in 11/14 evaluable cases, the amount increased as compared to day 1.…”