Phase II/III placebo-controlled randomized trial of safety and efficacy of growth hormone treatment in incomplete chronic traumatic spinal cord injury

Esclarín-Ruz, Ana; Rodriguez-Carrión, I; Ceruelo-Abajo, Silvia; Palazón-García, Ramiro; Ayuga-Loro, F; Carrasco-Lopez, Carmen; Alcobendas-Maestro, M.; Casado-López, R.; Talavera-Díaz, Francisco; Soto-León, Vanesa; Campolo, Michela; Romero-Ganuza, F.J.; Florensa-Vila, José; Garcia-Marco, David; Rotondi, Mario; Oliviero, Antonio

doi:10.1038/s41393-021-00662-0

Spinal Cord

2021

DOI: 10.1038/s41393-021-00662-0

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Phase II/III placebo-controlled randomized trial of safety and efficacy of growth hormone treatment in incomplete chronic traumatic spinal cord injury

Ana Esclarín-Ruz

I Rodriguez-Carrión

Silvia Ceruelo-Abajo

et al.

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2024

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Cited by 2 publications

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Pharmacological management of secondary chronic spinal cord injury: a systematic review

Migliorini,

Cocconi,

Schäfer

et al. 2024

British Medical Bulletin

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Introduction Spinal cord injury (SCI) may bring lifelong consequences for affected patients and a high financial burden to the health care system. Source of data Published peer-reviewed scientific articles identified from EMBASE, Google Scholar, PubMed and Scopus. Areas of agreement Surgery and blood pressure management are the main targets in acute SCI to avoid secondary damage. Areas of controversy The management of secondary chronic SCI is challenging, with unpredictable outcomes. Growing points Given the lack of consensus on pharmacological therapy for acute and secondary chronic SCI, the present study analyses the currently available drugs and treatment options to manage secondary chronic SCI. Areas timely for developing research Different approaches exist for the pharmacological management of secondary chronic SCI. One of the most investigated drugs, 4-aminopyridine, improves central motor conduction and shows improvement in neurological signs. Positive results in different areas have been observed in patients receiving the anti-spastic drugs tizanidine and baclofen or Granulocyte colony-stimulating factor. Growth hormone showed only minimal or no significant effects, and the therapy of secondary chronic SCI with riluzole has been poorly researched to date.

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Pharmacological management of secondary chronic spinal cord injury: a systematic review

Migliorini,

Cocconi,

Schäfer

et al. 2024

British Medical Bulletin

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Growth Hormone Neuroprotective Effects After an Optic Nerve Crush in the Male Rat

Epardo,

Balderas-Márquez,

Rodríguez-Arzate

et al. 2024

Invest. Ophthalmol. Vis. Sci.

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Phase II/III placebo-controlled randomized trial of safety and efficacy of growth hormone treatment in incomplete chronic traumatic spinal cord injury

Cited by 2 publications

References 35 publications

Pharmacological management of secondary chronic spinal cord injury: a systematic review

Pharmacological management of secondary chronic spinal cord injury: a systematic review

Growth Hormone Neuroprotective Effects After an Optic Nerve Crush in the Male Rat

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