Phase II study of multiple daily fractionations in the palliation of advanced pelvic malignancies: Preliminary report of RTOG 8502

Palliation of Pelvic and Head and Neck Cancer with Paclitaxel and a Novel Radiotherapy Regimen

“…The preliminary report demonstrated an equivalent response rate to the previous 10 Gy per fraction schedule and a low late complication rate (less than 5%). 3 To determine the impact of tumor repopulation on tumor response and palliative effect, this study was continued as a phase 3 trial comparing a 2-week break with a 4-week break. In this study there was no difference in response rate or late complications between the arms but there was a trend toward increased acute toxicity in the 2-week rest arm.…”

Clinical Usefulness of Mohs' Paste for Genital Bleeding from the Uterine Cervix or Vaginal Stump in Gynecologic Cancer

“…13 Palliative radiation therapy using either external beams or brachytherapy is one of the most effective strategies for hemostasis. 2,5 In this study, hemostasis was also achieved in patients previously treated with radiation therapy. Thus, it is likely that combined treatment of radiation therapy and Mohs' paste can lead to excellent hemostasis and durable tumor control in radiation naive patients.…”

“…In patients with increased genital bleeding, palliative radiation therapy or hypogastric artery ligations have been considered when hemostasis from recurrent cervical cancer could not be achieved by gauze tampons. [2][3][4][5][6] In the 1930s, Mohs first reported that chemical fixation using 20% zinc chloride causes tissue necrosis. He developed a method of microscopically controlled tumor excision as a chemosurgery technique.…”

Use of palliative radiotherapy trials for clinical biomarker development

“…Trials of palliative radiotherapy in other sites (e.g. abdomen or pelvis) have largely been devoted to demonstrating efficacious palliation through the assessment of symptom response following conventional palliative regimens such as 30 Gy/10# or 20 Gy/5# [52][53][54][55][56][57].…”