Phase II Trial of Pleural Photodynamic Therapy and Surgery for Patients With Non–Small-Cell Lung Cancer With Pleural Spread

Friedberg, Joseph S.; Stevenson, James P.; Zhu, Timothy C.; Busch, Theresa M.; Shin, Daniel B.; Smith, Debbie; Culligan, Melissa; Dimofte, Andreea; Glatstein, Eli; Hahn, Stephen M.

doi:10.1200/jco.2004.07.097

Cited by 105 publications

(76 citation statements)

References 23 publications

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“…Also, clinical trials examining debulking surgery followed by intraoperative photofirin-mediated PDT for peritoneal or pleural dissemination showed good local control rates with acceptable toxicity (33)(34)(35). The anti-tumor effects of photofirin-mediated PDT were more potent than those of 5-ALA-mediated PDT, but the toxicity rates were higher.…”

Section: Discussionmentioning

confidence: 99%

Talaporfin-mediated photodynamic therapy for peritoneal metastasis of gastric cancer in an in vivo mouse model: Drug distribution and efficacy studies

Kishi¹

2009

Int J Oncol

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Abstract. Photodynamic therapy (PDT) is a potential treatment for the peritoneal dissemination of gastric cancer, because its cytotoxicity is limited to superficial lesions. We examined the accumulation of talaporfin in peritoneal metastatic nodules and determined the optimal laser condition for these nodules. We also evaluated the pathological response after therapy. We created a peritoneal metastasis model in nude mice using the MKN-45 EGFP cell line. We evaluated the accumulation of talaporfin in peritoneal metastatic nodules and normal organs by spectrophotometric analysis 2-8 h after i.p. talaporfin. To determine optimal PDT conditions, we treated metastatic nodules and the small intestine using multiple laser doses (2, 5, and 10 J/cm 2 , respectively). Accumulation of talaporfin was detected in metastatic nodules in higher intensities than in the small intestine. The fluorescent intensity of the peritoneal metastatic nodules gradually decreased dependent on the time interval between the laser treatment and talaporfin administration. Fluorescent intensity in the small intestine decreased more than in the metastatic nodules. The pathological response rates by dose were 52.5% at 2 J/cm 2 , 43.2% at 5 J/cm 2 , and 64.4% at 10 J/cm 2 , respectively, when the laser treatment was used 2 h after talaporfin administration, whereas at 4 h, they were 20.8, 25.5, and 26.2%, respectively. Finally, the recommended treatment conditions were considered to be a 2 J/cm 2 laser dose and a 4-h interval in terms of toxicity. Talaporfin-mediated PDT may be an effective treatment modality for patients with advanced gastric adenocarcinoma and metastatic peritoneal nodules.

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Section: Discussionmentioning

confidence: 99%

Talaporfin-mediated photodynamic therapy for peritoneal metastasis of gastric cancer in an in vivo mouse model: Drug distribution and efficacy studies

Kishi¹

2009

Int J Oncol

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“…A phase II trial enrolling 22 patients with pleural spread and clinical T4 NSCLC was conducted in which patients underwent surgery with complete or partial tumor debulking, followed by hemithoracic pleural PDT or PDT alone. The median overall survival was 21.7 months, compared with 6-9 months for similar patients based on historical controls [13].…”

Section: Introductionmentioning

confidence: 97%

“…For lung cancer, the phase II trial at the University of Pennsylvania proved our point of view. It showed 73.3% of 6-month localized disease control for the cohort and a median overall survival of 21.7 months, compared with 6-9 months survival for similar patients treated with the non-operative standard of care and based upon historical controls [13]. Compared with surgery without PDT for patients of lung cancer with pleural spread in literature, the outcome of patients receiving surgery plus PDT is beter [18,19].…”

Section: Commentsmentioning

confidence: 99%

Pleural Photodynamic Therapy and Surgery in Thoracic Cancer Patients with Pleural Spread

Chen¹,

Lee²

2017

Photomedicine - Advances in Clinical Practice

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Pleural spread from non-small cell lung cancer is a diicult situation. The average survival in the situation is about 6-9 months. We investigate the current management of this challenging condition. Although, there is no much evidence found in the literature, we do see the pleural photodynamic therapy giving some promising light in the dark night. However, the patients still require complete neoadjuvant and adjuvant therapies, as well as radical tumor resection. Pleural PDT is one of the multi-modality treatments, which combined can achieve satisfactory oncological results. The long-term survival can be achieved in more than half the patients. However, the side efects of pleural PDT include skin hypersensitivity, trachea and esophageal perforation, and ARDS, which we should keep in mind.

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“…В последние годы некоторые авторы выполняют ци-торедуктивные операции в сочетании с внутриплевраль-ной фотодинамической терапией [7,8]. Результаты многочисленных экспериментальных и клинических исследований свидетельствуют о том, что мощным адъювантом циторедуктивной терапии является аппаратная гипертермия, благодаря которой ранее рези-стентные к повреждающим факторам опухолевые клетки становятся чувствительными к противоопухолевым пре-паратам и лучевому воздействию [9].…”

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Intrapleural hyperthermic chemotherapy after cytoreductive surgery in patients with pleural tumors

Пикин¹,

Ryabov²,

Хороненко³

et al. 2015

Onkol. Z. im. P.A. Gercena

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Рассмотрены современные подходы к лечению больных с первичным и метастатическим поражением плевры. Пред-ставлен опыт применения в МНИОИ им. П.А. Герцена методики внутриплевральной гипертермической химиотерапии с препаратом цисплатин у 7 больных с опухолевым поражением плевры. Отражены методология процедуры, особенности анестезиологического пособия, проанализирован характер осложнений. Приведено наблюдение успешного применения методики у пациента с мезотелиомой плевры. Ключевые слова: первичное и метастатическое поражение плевры, внутриплевральная гипертермическая химиотерапия.The paper considers approaches to treating patients with primary pleural malignancy and metastatic involvement. It presents experience in using cisplatin in the procedure of intrapleural hyperthermic chemotherapy in 7 patents with pleural tumors. It shows the methodology of the procedure and the specific features of anesthetic support and analyzes the nature of complications. The authors describe a case of successful use of the procedure in a patient with pleural mesothelioma.Keywords: primary pleural malignancy and metastatic involvement, intrapleural hyperthermic chemotherapy.

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Phase II Trial of Pleural Photodynamic Therapy and Surgery for Patients With Non–Small-Cell Lung Cancer With Pleural Spread

Abstract: Our results indicate surgery and PDT can be performed safely with very good local control. The median survival of 21.7 months, calculated from the time of surgery and PDT is encouraging. Further evaluation of this therapy is warranted.

Cited by 105 publications

References 23 publications

Talaporfin-mediated photodynamic therapy for peritoneal metastasis of gastric cancer in an in vivo mouse model: Drug distribution and efficacy studies

Talaporfin-mediated photodynamic therapy for peritoneal metastasis of gastric cancer in an in vivo mouse model: Drug distribution and efficacy studies

Pleural Photodynamic Therapy and Surgery in Thoracic Cancer Patients with Pleural Spread

Intrapleural hyperthermic chemotherapy after cytoreductive surgery in patients with pleural tumors

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