Phase III Evaluation of Fluoxetine for Treatment of Hot Flashes

Abstract

This dose of fluoxetine resulted in a modest improvement in hot flashes.

Levetiracetam for the treatment of hot flashes: a phase II study

“…The reduction is similar to that seen in similarly conducted pilot trials conducted with other agents (venlafaxine, paroxetine, and gabapentin) that were subsequently shown to be better than placebos in randomized double-blinded clinical trials [17,26,34,37,51,66] (Fig. 4).…”

The impact of cytochrome P450 2D6 metabolism in women receiving adjuvant tamoxifen

“…The newer anti-depressant drugs, such as the selective serotonin reuptake inhibitors and the serotonin and norepinephrine reuptake inhibitors are commonly administered with tamoxifen in breast cancer patients to treat depression or alleviate hot-flashes and have been considered an important advance in the non-hormonal therapy of hot-flashes [13,[30][31][32][33]. Current practice surveys suggest that upwards of 25% of tamoxifen-treated patients who experience hot-flashes are considered for therapy with anti-depressants to alleviate hot-flashes [34].…”

Hot Flash, Hot Topic: Conceptualizing Menopausal Symptoms From a Cognitive-Behavioral Perspective

“…There has also been an increased emphasis on the use of selective serotonin reuptake inhibitors (SSRIs) for reduction of hot flashes, specifically controlled release paroxetine, with some researchers suggesting that the reuptake of serotonin may somehow affect this process as well (Stearns, Beebe, Iyengar, & Dube, 2003), particularly in women experiencing hot flashes after treatment for breast cancer (Loprinzi, Kugler, & Sloan, 2000;Loprinzi, Sloan, & Perez, 2002). However, the mechanism for this effect is yet to be fully elucidated.…”