2013
DOI: 10.1200/jco.2012.43.2674
|View full text |Cite
|
Sign up to set email alerts
|

Phase III Trial of Chemoradiotherapy for Anaplastic Oligodendroglioma: Long-Term Results of RTOG 9402

Abstract: For the subset of patients with 1p/19q codeleted AO/AOA, PCV plus RT may be an especially effective treatment, although this observation was derived from an unplanned analysis.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1
1
1

Citation Types

25
645
0
20

Year Published

2013
2013
2023
2023

Publication Types

Select...
10

Relationship

0
10

Authors

Journals

citations
Cited by 1,013 publications
(690 citation statements)
references
References 33 publications
25
645
0
20
Order By: Relevance
“…[4][5][6]  Anaplastic oligodendroglial tumors with 1p/19q co-deletions should no longer be treated with radiotherapy alone, but with alkylating agent chemotherapy, with or without radiotherapy. [4][5][6]  The introduction of molecular markers into the next WHO Classification of Tumors of the Nervous System is inevitable.…”
Section: Key Advancesmentioning
confidence: 99%
“…[4][5][6]  Anaplastic oligodendroglial tumors with 1p/19q co-deletions should no longer be treated with radiotherapy alone, but with alkylating agent chemotherapy, with or without radiotherapy. [4][5][6]  The introduction of molecular markers into the next WHO Classification of Tumors of the Nervous System is inevitable.…”
Section: Key Advancesmentioning
confidence: 99%
“…Chromosome 1p and 19q codeletion, the genetic hallmark of oligodendrogliomas associated with long survival and chemo-radio sensitivity, represents the prototype molecular marker with unequivocal diagnostic, prognostic, and therapeutic utilities in diffuse gliomas. [3][4][5][6][7] Isocitrate dehydrogenase (IDH) mutation is probably the most important molecular marker discovered in diffuse gliomas with breakthrough clinical values in the recent years. 8 Apart from its use in difficult diagnostic situations, [8][9][10] mutation of this enzyme also stratifies diffuse gliomas prognostically.…”
mentioning
confidence: 99%
“…Updated results of the primary analysis confirmed that disease control overall was mainly the same after RT or CT. 2 However, the secondary (and exploratory) analyses were perhaps the most intriguing and surprising. For example, despite the observation from other trials that (IDH mutation and) codeletion predicts the greatest chemosensitivity of anaplastic gliomas, 6,7 CT was, disappointingly to us, at best equi-efficacious as RT in the CIMP codel molecular subgroup of NOA-04. 2 An analogous observation was reported recently for (IDH mutant and) codeleted low-grade (WHO grade II) gliomas.…”
mentioning
confidence: 58%