Phase-Inversion Sonography During the Liver-Specific Late Phase of  Contrast Enhancement

Albrecht, Thomas; Hoffmann, C. W.; Schmitz, Stephan A.; Schettler, S.; Overberg, Aline; Germer, Christoph T.; Wolf, Karl‐Jürgen

doi:10.2214/ajr.176.5.1761191

Cited by 138 publications

(95 citation statements)

References 19 publications

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“…In our case, perfusional angiosonography produced results similar to those obtained with CT, as do pulse-inversion harmonic imaging techniques. [5][6][7][8] The changes in the arterial-phase enhancement pattern of hepatic metastases from colorectal carcinoma in our case did not seem to reflect changes in tumor activity. Specifically, 2 lesions that no longer exhibited arterial-phase enhancement after 6 months of chemotherapy still showed signs of progression, as did 3 other lesions that had retained the hypervascular pattern on perfusional angiosonography.…”

Section: Discussioncontrasting

confidence: 64%

Liver metastases from rectal carcinoma: Disease progression during chemotherapy despite loss of arterial‐phase hypervascularity on real‐time contrast‐enhanced harmonic sonography at low acoustic energy

Piscaglia

Gaiani

Tamberi

et al. 2003

J of Clinical Ultrasound

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We used a new sonographic technique, real-time contrast-enhanced harmonic sonography at low acoustic energy, to evaluate liver perfusion and liver metastases from colorectal cancer in a 73-year-old woman after chemotherapy. After 6 weeks of chemotherapy, liver metastases that had been clearly visible on conventional sonography before chemotherapy were no longer detectable on conventional sonography but were still evident on contrast-enhanced sonography. At about 6 months after initiation of chemotherapy, the lesions were all visible again on conventional sonography and had become significantly larger, although some no longer showed contrast enhancement during the arterial phase. In this case, changes in arterial perfusion over time did not parallel the response of liver metastases to chemotherapy.

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Section: Discussioncontrasting

confidence: 64%

Liver metastases from rectal carcinoma: Disease progression during chemotherapy despite loss of arterial‐phase hypervascularity on real‐time contrast‐enhanced harmonic sonography at low acoustic energy

Piscaglia

Gaiani

Tamberi

et al. 2003

J of Clinical Ultrasound

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“…Contrast-enhanced ultrasound has meanwhile been evaluated for numerous organs and has been proven to have a clear role in the detection and differential diagnosis of liver lesions [7][8][9][10][11][12][13][14][15] . For this, low-MI imaging is the technique of choice since it allows the liver to be scanned in the usual way.…”

Section: Contrast-specific Imaging Techniquesmentioning

confidence: 99%

Contrast-enhanced ultrasound for examining tumor biology

Delorme

Krix²

2006

Cancer Imaging

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This paper reviews the potential of ultrasound for assessing the viability and biological behavior of tumors. Unlike color Doppler sonography, modern techniques for contrast-enhanced ultrasound permit the measurement of tissue perfusion irrespective of vessel size or flow velocity. Perfusion can also be assessed quantitatively, using replenishment kinetics or derivates thereof. The perfusion of tumors is a surrogate parameter of their viability and may mirror their response to therapy. Furthermore, the degree of vascularity in a tumor may express its aggressiveness and help to predict its response to treatment. In animal models, a decrease in blood flow has been shown to precede a shrinkage of tumors treated with anti-angiogenic compounds. In liver metastases, arterial and portal blood supply can be assessed separately, and a response to stereotactic radiotherapy was found to go along with a decrease in arterial perfusion. Moreover, a relatively high arterial perfusion of liver metastases may predict a response to chemotherapy. Contrastenhanced ultrasound may be a potent tool for assessing the effects of anti-angiogenic treatment in patients.

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“…Some studies have found that CEUS improved sensitivity by more than 50%, and was especially helpful for metastases smaller than 10 mm [44][45]. Our recent study found that CEUS using high-frequency linear probe could detect more lesions than routine convex probe for the lesions less than 10mm in diameter and located within 60mm below liver surface (89% vs 66%, p<0.05), and combining convex and linear probe CEUS, the sensitivity for detection of small CRLMs could reach 97% when taking CECT and CEMRI as golden standard.…”

Section: Detection and Characterizationmentioning

confidence: 99%

Ultrasound Examination in Detection and Characterization of Colorectal Liver Metastases

Qin¹,

Liu²

2015

International Journal of Radiology

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The detection and characterization of colorectal liver metastases (CRLMs) depend firstly and totally on imaging studies. Transabdominal ultrasound (US) is the most cost-effective and readily available modality to screen the liver. Contrast-enhanced ultrasound (CEUS) has shown high performance comparable to contrast-enhanced computed tomography and magnetic resonance imaging in detection and characterization of CRLMs. Intraoperative ultrasonography (IOUS) is the golden standard for detection of CRLMs and frequently used for intraoperative decision making. This review illustrates the findings on ultrasonic examinations (including US, CEUS and IOUS) of CRLMs with an emphasis on unique capability and appropriate indications of ultrasonic examinations in the detection and characterization of CRLMs. We aim to highlight the advan¬tages of ultrasonic examinations, as well as underscoring potential pitfalls and limitations.

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Phase-Inversion Sonography During the Liver-Specific Late Phase of Contrast Enhancement

Cited by 138 publications

References 19 publications

Liver metastases from rectal carcinoma: Disease progression during chemotherapy despite loss of arterial‐phase hypervascularity on real‐time contrast‐enhanced harmonic sonography at low acoustic energy

Liver metastases from rectal carcinoma: Disease progression during chemotherapy despite loss of arterial‐phase hypervascularity on real‐time contrast‐enhanced harmonic sonography at low acoustic energy

Contrast-enhanced ultrasound for examining tumor biology

Ultrasound Examination in Detection and Characterization of Colorectal Liver Metastases

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