“…These include both full-reference or no-reference measures of the PSF, 5, 20 the OTF, 12, 30 the MTF, 31, 32 the PTF, 33 specific images 19,34,35 or image distributions. 28 One of the most challenging issues related to optimization of hybrid imaging systems is to include the entire imaging acquisition and observation which therefore includes detector noise, image processing, and the human visual perception of the final image.…”