The nuclear structure for some target nuclei namely: 32 S, 58 Ni, 89 Y, 90 Zr, 100 Mo and 197 Au used for production of the therapeutic radionuclides; 32 P, 58 Co, 89 Sr, 90 Y, 99 Mo, 100 Tc, 197 Pt and 197 Hg has been investigated using Skyrme-Hartree-Fock method based on Skyrme effective two-body interaction. For these purpose, we have calculated the various nuclear densities, the corresponding root mean square radii and nuclear binding energies. The density dependent initial neutron and proton exciton numbers have been also calculated which give the ability to investigate the neutron and proton induced reaction cross-sections for these target nuclei using hybrid model for pre-equilibrium nuclear reactions. The calculated results are compared with available experimental data.