Phase‐Regulated Sensing Mechanism of MoS<sub>2</sub> Based Nanohybrids toward Point‐of‐Care Prostate Cancer Diagnosis

Ying, Zi; Feng, Lingyan; Ji, Dongqing; Yuan, Zhe; Chen, Wei; Dai, Yifan; Janyasupab, Metini; Li, Xinxin; Wen, Weijia; Liu, Chung Chiun

doi:10.1002/smll.202000307

Cited by 15 publications

(14 citation statements)

References 58 publications

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“…In addition, electrochemical sensors based on MoS 2 can also sensitively detect miRNA, triiodothyronine, cytokeratin 19 fragment antigen 21-1, EpCAM, and α-methylacyl-CoA racemase [ [114] , [115] , [116] , [117] , [118] , [119] ]. These probes were prepared by functionally modifying specifical ligands at the MoS 2 -based nanocomposites.…”

Section: Biosensorsmentioning

confidence: 99%

MoS2-based nanocomposites for cancer diagnosis and therapy

Wang

Li-hua

Huang

et al. 2021

Bioactive Materials

148

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Molybdenum is a trace dietary element necessary for the survival of humans. Some molybdenum-bearing enzymes are involved in key metabolic activities in the human body (such as xanthine oxidase, aldehyde oxidase and sulfite oxidase). Many molybdenum-based compounds have been widely used in biomedical research. Especially, MoS 2 -nanomaterials have attracted more attention in cancer diagnosis and treatment recently because of their unique physical and chemical properties. MoS 2 can adsorb various biomolecules and drug molecules via covalent or non-covalent interactions because it is easy to modify and possess a high specific surface area, improving its tumor targeting and colloidal stability, as well as accuracy and sensitivity for detecting specific biomarkers. At the same time, in the near-infrared (NIR) window, MoS 2 has excellent optical absorption and prominent photothermal conversion efficiency, which can achieve NIR-based phototherapy and NIR-responsive controlled drug-release. Significantly, the modified MoS 2 -nanocomposite can specifically respond to the tumor microenvironment, leading to drug accumulation in the tumor site increased, reducing its side effects on non-cancerous tissues, and improved therapeutic effect. In this review, we introduced the latest developments of MoS 2 -nanocomposites in cancer diagnosis and therapy, mainly focusing on biosensors, bioimaging, chemotherapy, phototherapy, microwave hyperthermia, and combination therapy. Furthermore, we also discuss the current challenges and prospects of MoS 2 -nanocomposites in cancer treatment.

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Section: Biosensorsmentioning

confidence: 99%

MoS2-based nanocomposites for cancer diagnosis and therapy

Wang

Li-hua

Huang

et al. 2021

Bioactive Materials

148

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“…To achieve these desired functions, we de novo designed and constructed a miniaturized and mass-producible nano-structured sensor system through programming the material properties of the hybrid nanocomposites. To construct a sensing interface enabling a high signal-to-noise ratio, we employed a nanostructured pillar array providing efficient mass transport and electron transfer channels for signal amplification 6 . Specifically, ordered ZnO nanopillar was grown onto ultrathin 1T MoS2 nanosheets forming a hybrid nanostructure.…”

Section: Rational Engineered Hybrid Nanostructured Electrode As a Sensing Interfacementioning

confidence: 99%

“…Ultrathin MoS2 with 2H-phase was synthesized by sonication exfoliation of bulk MoS2 in liquid nitrogen 6 . Typically, 0.1 g MoS2 was dispersed into 20 mL KOH (1 g) solution.…”

Section: Synthesis Of 2h-mos2mentioning

confidence: 99%

Encoding sensing functions into material interface for a rationally engineered integrated electrochemical liquid biopsy

Yuan

Zhu

Ying

et al. 2022

Preprint

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Limited healthcare capacity highlights the needs of integrated and simple sensing systems for personalized health monitoring. However, only a limited set of sensors can be employed for point-of-care applications, emphasizing the lack of a generalizable engineering strategy for sensor construction. Here, we report a de novo rational engineering strategy for the construction of an integrated electrochemical liquid biopsy (ELB) platform capable of direct profiling cancer exosomes from blood. Using a bottom-up approach for sensor design, a series of critical sensing functions is considered and encoded into the material interface by programming the electrode material with different chemical and structure features. We present that the rationally engineered electrochemical liquid biopsy platform is able to achieve one-step sensor fabrication, target isolation, non-fouling and high-sensitivity sensing, direct signal transduction and multiplexed detection. Integrating the multiplexed sensing with principal component analysis, we demonstrate the capability of the programmed sensing system on differentiating cancerous groups from healthy controls by analyzing clinical samples from lung cancer patients.

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“…However, to improve the biosensing capability of MoS 2 , the basal surface can be functionalized to respond specifically and selectively to a target molecule [ 79 ]. Biofunctionalization of MoS 2 improved detection of various cancer biomarker proteins, e.g., prostate-specific antigens [ 80 ], nuclear matrix protein 22 (NMP22) and cytokeratin 8 (CK8) [ 81 ] or enzymes, e.g., Alpha-methylacyl-CoA racemase (AMACR) [ 82 ] and, as such, an improved low LOD was reported. Despite an improvement in sensitivity of MoS 2 -based biosensors, selective detection of a particular biomarker is still a difficult task to resolve, thereby requiring a blocking agent to prevent non-specific binding during sensing reactions [ 83 ].…”

Section: Nanomaterials Based Aptamer Sensors As Diagnostic Toolmentioning

confidence: 99%

Recent Advances in Nanomaterial-Based Aptasensors in Medical Diagnosis and Therapy

et al. 2021

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Rapid and accurate diagnosis of various biomarkers associated with medical conditions including early detection of viruses and bacteria with highly sensitive biosensors is currently a research priority. Aptamer is a chemically derived recognition molecule capable of detecting and binding small molecules with high specificity and its fast preparation time, cost effectiveness, ease of modification, stability at high temperature and pH are some of the advantages it has over traditional detection methods such as High Performance Liquid Chromatography (HPLC), Enzyme-linked Immunosorbent Assay (ELISA), Polymerase Chain Reaction (PCR). Higher sensitivity and selectivity can further be achieved via coupling of aptamers with nanomaterials and these conjugates called “aptasensors” are receiving greater attention in early diagnosis and therapy. This review will highlight the selection protocol of aptamers based on Traditional Systematic Evolution of Ligands by EXponential enrichment (SELEX) and the various types of modified SELEX. We further identify both the advantages and drawbacks associated with the modified version of SELEX. Furthermore, we describe the current advances in aptasensor development and the quality of signal types, which are dependent on surface area and other specific properties of the selected nanomaterials, are also reviewed.

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Phase‐Regulated Sensing Mechanism of MoS₂ Based Nanohybrids toward Point‐of‐Care Prostate Cancer Diagnosis

Abstract: Scheme 1. AMACR involved pristanic acid metabolism pathway.

Cited by 15 publications

References 58 publications

MoS2-based nanocomposites for cancer diagnosis and therapy

MoS2-based nanocomposites for cancer diagnosis and therapy

Encoding sensing functions into material interface for a rationally engineered integrated electrochemical liquid biopsy

Recent Advances in Nanomaterial-Based Aptasensors in Medical Diagnosis and Therapy

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Phase‐Regulated Sensing Mechanism of MoS2 Based Nanohybrids toward Point‐of‐Care Prostate Cancer Diagnosis

Abstract: Scheme 1. AMACR involved pristanic acid metabolism pathway.

Cited by 15 publications

References 58 publications

MoS2-based nanocomposites for cancer diagnosis and therapy

MoS2-based nanocomposites for cancer diagnosis and therapy

Encoding sensing functions into material interface for a rationally engineered integrated electrochemical liquid biopsy

Recent Advances in Nanomaterial-Based Aptasensors in Medical Diagnosis and Therapy

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Phase‐Regulated Sensing Mechanism of MoS₂ Based Nanohybrids toward Point‐of‐Care Prostate Cancer Diagnosis