Phase relations of hippocampal projection cells and interneurons to theta activity in the anesthetized rat

Buzsáki, G; Eidelberg, E.

doi:10.1016/0006-8993(83)90665-0

Cited by 122 publications

(71 citation statements)

References 20 publications

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“…In this regard, future pharmacological studies and molecular studies attempting to clarify the link between these EEG recordings of LICI to GABA B receptor-mediated mechanisms in the cortex are needed. Additionally, future studies parsing EEG measures of LICI into its component frequencies (eg, delta, theta, alpha beta), are also needed to further characterize its physiology, as several lines of evidence suggest that theta frequencies may be closely tied to GABAergic inhibitory potentials in the cortex (Amzica and Steriade, 1995;Buzsaki, 1997;Buzsaki and Chrobak, 1995;Buzsaki and Eidelberg, 1983;Patenaude et al, 2003;Whittington et al, 1995;Ylinen et al, 1995a, b).…”

Section: Discussionmentioning

confidence: 99%

Long-Interval Cortical Inhibition from the Dorsolateral Prefrontal Cortex: a TMS–EEG Study

Daskalakis

Farzan

Barr

et al. 2008

Neuropsychopharmacol

218

194

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Several studies have demonstrated that cortical inhibition (CI) can be recorded by paired transcranial magnetic stimulation (TMS) of the motor cortex and recorded by surface electromyography (EMG). However, recording CI from other cortical regions that are more closely associated with the pathophysiology of some neurological and psychiatric disorders (eg, dorsolateral prefrontal cortex (DLPFC) in schizophrenia) was previously unattainable. This study, therefore, was designed to investigate whether CI could be measured directly from the motor cortex and DLPFC by combining TMS with electroencephalography (EEG). Long-interval CI (LICI) is a TMS paradigm that was used to index CI in the motor cortex and DLPFC in healthy subjects. In the motor cortex, LICI resulted in significant suppression (32.8 ± 30.5%) of mean cortical evoked activity on EEG, which was strongly correlated with LICI recorded by EMG. In the DLPFC, LICI resulted in significant suppression (30.1±26.9%) of mean cortical evoked activity and also correlated with LICI in the motor cortex. These data suggest that CI can be recorded by combining TMS with EEG and may facilitate future research attempting to ascertain the role of CI in the pathophysiology of several neurological and psychiatric disorders.

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Section: Discussionmentioning

confidence: 99%

Long-Interval Cortical Inhibition from the Dorsolateral Prefrontal Cortex: a TMS–EEG Study

Daskalakis

Farzan

Barr

et al. 2008

Neuropsychopharmacol

218

194

View full text Add to dashboard Cite

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“…Putative pyramidal cells in the CA1 region were distinguished from putative interneurons using standard criteria (Ranck, 1973;Fox and Ranck, 1981;Buzsáki and Eidelberg, 1983;McNaughton et al, 1983). The classification criteria for inclusion of a unit into the pyramidal cell category was that the unit must fire at least a small number of complex spike bursts during the recording session, have spike width (peak to valley) of Ն250 s, and an overall mean spike rate of Ͻ2.5 Hz during running on the track.…”

Section: Methodsmentioning

confidence: 99%

The Effects of GluA1 Deletion on the Hippocampal Population Code for Position

Resnik

McFarland²,

Sprengel

et al. 2012

Journal of Neuroscience

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The GluA1 subunit of AMPA receptors (AMPARs) is critical for hippocampal synaptic transmission and plasticity. Here, we measured the activity of single units from the CA1 region of the hippocampus while GluA1 knock-out (GluA1) and wild-type (WT) mice traversed a linear track. Although overall firing rates were similar, GluA1 Ϫ/Ϫ neurons were more likely to spike in bursts, but at lower burst frequencies, compared with WT neurons. GluA1 Ϫ/Ϫ neurons showed large reductions in all measures of spatial and directional selectivity compared with WT neurons. Consistent with these alterations of single-neuron properties, the accuracy of the population code for position was substantially reduced in GluA1 Ϫ/Ϫ , yet it is predicted to approach the accuracy of WT with increasing population size. The absolute representation of space, independent of movement direction, was greatly diminished in GluA1 Ϫ/Ϫ mice and is predicted to remain reduced even for larger populations. Finally, we found that the rate maps of GluA1 Ϫ/Ϫ neurons showed increased trial-by-trial variability but reduced experiential plasticity compared with the WT. These results reveal the critical contribution of GluA1-containing AMPARs to individual place cells and the hippocampal population code for space, which could explain the selective behavioral impairments observed in these mice.

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“…During in vivo experiments, whereas most interneurons fire in phase with theta rhythm, a small number of interneurons in st. radiatum reduce their firing rate during theta activity ("theta-off cells") (Buzsaki and Eidelberg, 1983;Colom and Bland, 1987). Other st. radiatum interneurons in area CA1 are inhibited during sharp-wave "ripples" in vivo (Freund and Buzsaki, 1996).…”

Section: Class II Interneurons Are Inhibited By Other Interneuronsmentioning

confidence: 99%

Functionally Distinct Groups of Interneurons Identified During Rhythmic Carbachol Oscillations in HippocampusIn Vitro

1998

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During distinct behavioral states, the hippocampus exhibits characteristic rhythmic electrical activity. Evidence in vivo suggests that both principal pyramidal cells and GABAergic interneurons participate in generating oscillations. We found that during rhythmic oscillations in area CA3, functionally distinct classes of interneurons could be identified, although all recorded interneurons had similar dendritic and axonal arbors. One group of interneurons was powerfully excited by CA3 pyramidal cells, whereas two other interneuron groups were relatively unaffected by pyramidal cell firing. One of these groups of interneurons was potently inhibited by other local interneurons during the pyramidal cell bursts. Our findings emphasize that morphologically similar cells are wired together very differently within the local circuit. The classes of hippocampal interneurons we have tentatively defined may be used during distinct behavioral states to switch the local network from one oscillatory state to another.

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Phase relations of hippocampal projection cells and interneurons to theta activity in the anesthetized rat

Cited by 122 publications

References 20 publications

Long-Interval Cortical Inhibition from the Dorsolateral Prefrontal Cortex: a TMS–EEG Study

Long-Interval Cortical Inhibition from the Dorsolateral Prefrontal Cortex: a TMS–EEG Study

The Effects of GluA1 Deletion on the Hippocampal Population Code for Position

Functionally Distinct Groups of Interneurons Identified During Rhythmic Carbachol Oscillations in HippocampusIn Vitro

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