Phase relations of theta oscillations in a computer model of the hippocampal CA1 field: Key role of Schaffer collaterals

Mysin, Ivan; Kitchigina, Valentina F.; Kazanovich, Yakov

doi:10.1016/j.neunet.2019.04.004

Cited by 18 publications

(18 citation statements)

References 115 publications

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“…The theoretical ideas about the mechanisms of theta rhythm suggested in this paper are based on our previous work (Mysin et al, 2019). In our previous study, we showed that input from the CA3 field via Shaffer collaterals plays a key role in theta rhythm generation in the CA1 field.…”

Section: Model Of Theta Rhythmmentioning

confidence: 87%

“…Our contribution to the proposed general model was to develop a theta rhythm model (Mysin et al, 2019). In this section, we want to discuss in detail the proposed mechanism of theta rhythm.…”

Section: Theta Rhythm Modelmentioning

confidence: 99%

“…The main ideas about the mechanism of theta rhythm generation are based on the results of our previous article (Mysin et al, 2019), but we have introduced additions to our theoretical scheme, which should be discussed in detail. One of the main results of our previous article was the idea of Shaffer collaterals as the main input forming the descending phase of the theta rhythm in the CA1 field.…”

Section: Theta Rhythm Modelmentioning

confidence: 99%

“…Theta rhythm generation requires input from the medial septum (MS) (Colgin, 2013;Vinogradova, 1995), slow gamma rhythm and ripple oscillations depend on input via Shaffer collaterals from the CA3 field, and the middle gamma rhythm depends on input via the perforant path from cells of the entorhinal cortex layer 3 (MEC) (Belluscio et al, 2012;Colgin et al, 2009;Colgin, 2015;Fernández-Ruiz et al, 2017). Many mathematical models have been proposed in the literature that describes many of the presented experimental observations individually (Börgers, Talei Franzesi, Lebeau, Boyden, & Kopell, 2012;Burgess & O'Keefe, 2011;Chance, 2012;Keeley, Fenton, & Rinzel, 2017;Mysin, Kitchigina, & Kazanovich, 2019;Saraga, Ng, & Skinner, 2006;Wang & Buzsáki, 1996). However, there is no model describing all observations in a single model with a single set of parameters.…”

Section: Introductionmentioning

confidence: 99%

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A model of the CA1 field rhythms

Mysin

2021

Preprint

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We propose a model of the main rhythms in the hippocampal CA1 field: theta rhythm, slow, middle, and fast gamma rhythms, and ripples oscillations. We have based this on data obtained from animals behaving freely. We have considered the modes of neuronal discharges and the occurrence of local field potential (LFP) oscillations in the theta and non-theta states at different inputs from the CA3 field, the medial entorhinal cortex, and the medial septum. In our work, we tried to reproduce the main experimental phenomena about rhythms in the CA1 field: the coupling of neurons to the phase of rhythms, cross-rhythm phase-phase and phase-amplitude coupling. Using computational experiments, we have proved the hypothesis that the descending phase of the theta rhythm in the CA1 field is formed by the input from the CA3 field via the Shaffer collaterals, and the ascending phase of the theta rhythm is formed by the inhibitory postsynaptic potentials from CCK basket cells. The slow gamma rhythm is coupled to the descending phase of the theta rhythm, since it also depends on the arrival of the signal via the Shaffer collaterals. The middle gamma rhythm is formed by the excitatory postsynaptic potentials of the principal neurons of the third layer of the entorhinal cortex, corresponds to experimental data. We were able to unite in a single mathematical model several theoretical ideas about the mechanisms of rhythmic processes in the CA1 field of the hippocampus.

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Section: Model Of Theta Rhythmmentioning

confidence: 87%

Section: Theta Rhythm Modelmentioning

confidence: 99%

Section: Theta Rhythm Modelmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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A model of the CA1 field rhythms

Mysin

2021

Preprint

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“…One possibility for the abnormal phasic relationships seen in Ts65Dn animals is excessive interneuronal contact with place cells, either through greater interneuronal number, or a larger number of synapses. Although modelling work suggests that theta within CA1 can be produced without direct septal input, septal input is critically involved in regulating phasic relationships with theta 58 . An imbalance in the ratio of inhibitory GABAergic to excitatory cholinergic/glutamatergic projections from MS to HPC in Ts65Dn animals may be sufficient to perturb phasic relationships with theta within the hippocampus.…”

Section: Discussionmentioning

confidence: 99%

Disordered phasic relationships between hippocampal place cells, theta, and gamma rhythms in the Ts65Dn mouse model of Down Syndrome

Heller

Freeburn

Finn

et al. 2020

Preprint

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Down Syndrome (DS) in humans is caused by trisomy of chromosome 21 and is marked by prominent difficulties in learning and memory. Decades of research have demonstrated that the hippocampus is a key structure in learning and memory, and recent work with mouse models of DS have shown changes in spectral coherence in the field potentials of hippocampus and regions important for executive function such as prefrontal cortex. One of the primary functional differences in DS is thought to be an excess of GABAergic innervation from Medial Septum (MS) to regions such as hippocampus. In these experiments, we probe in detail the activity of region CA1 of the hippocampus using in vivo electrophysiology in the Ts65Dn mouse model of DS in comparison to their non-trisomic 2N littermates. We find changes in hippocampal phenomenology that suggest that MS output, which drives theta rhythm in the hippocampus, is strongly altered. Moreover, we find that this change affects the phasic relationship of both CA1 place cells and gamma rhythms to theta. Since the phasic relationship of both of these aspects of hippocampal phenomenology to theta are thought to be critical for the segregation of encoding and retrieval epochs within hippocampus, it is likely that these changes are the neural substrates of the learning and memory deficits seen both in human DS and animal models such as Ts65Dn.

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Mechanisms and optogenetic control of rhythm slowing associated with Alzheimer’s disease: some views from dynamical modeling

Shen,

Zhang,

et al. 2024

Nonlinear Dyn

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Phase relations of theta oscillations in a computer model of the hippocampal CA1 field: Key role of Schaffer collaterals

Cited by 18 publications

References 115 publications

A model of the CA1 field rhythms

A model of the CA1 field rhythms

Disordered phasic relationships between hippocampal place cells, theta, and gamma rhythms in the Ts65Dn mouse model of Down Syndrome

Mechanisms and optogenetic control of rhythm slowing associated with Alzheimer’s disease: some views from dynamical modeling

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