In this work, mode-division multiplexing (MDM) phase-sensitive amplification (PSA) for all-optical mode selective and mode equalized phase regeneration is presented and investigated. MDM PSA relies on reasonable phase-matching conditions, which makes intramode four-wave mixing in the fiber much stronger than that of cross-mode. It enables multimode signals to interact mainly with the same spatial mode pumps and idlers. Thus, MDM signals can obtain synchronous phase regeneration and avoid cross talk with different mode signals. To achieve this, we designed an appropriate few-mode fiber by an inverse design method based on a neural network for obtaining the desired phase mismatch and low modal dispersion. The results show that effective phase regeneration can be achieved for the degraded 40 Gbit/s binary phase shift keying (BPSK) and quadrature phase shift keying (QPSK) signals. For BPSK signals, error vector magnitudes (EVMs) of the regenerated signal on two modes are reduced from
−
8.013
d
B
and
−
8.068
d
B
to
−
24.867
d
B
, and
−
26.090
d
B
, respectively. For QPSK signals, the EVMs are reduced from
−
16.767
d
B
and
−
16.583
d
B
to
−
24.867
d
B
and
−
24.822
d
B
, respectively.