Phase-sensitive black-blood coronary vessel wall imaging

Abd‐Elmoniem, Khaled Z.; Weiss, Robert G.; Stuber, Matthias

doi:10.1002/mrm.22286

Cited by 15 publications

(18 citation statements)

References 47 publications

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“…No statistical difference (P = .06) was found between the body mass index of subjects with CAD risk factors (mean, 25 6 5; range, [16][17][18][19][20][21][22][23][24][25][26][27][28][29][30][31][32][33][34] and healthy subjects (mean, 22 6 4; range, [20][21][22][23][24][25][26][27][28][29][30]. Subjects with CAD risk factors were significantly older than healthy subjects (P , .001), while there was no significant difference in age between men and women with CAD risk factors (P = .7).…”

Section: Resultsmentioning

confidence: 94%

“…Immediately after dual inversion, a navigator-restore pulse (31) was used to optimize navigator performance. Phase-sensitive signed-magnitude images were reconstructed (24) and used in all later analyses. All cine images were randomized, anonymized, and evaluated for image quality.…”

Section: Discussionmentioning

confidence: 99%

“…Another challenge facing successful vessel wall imaging is the inherent requirement of blood signal nulling. A phase-sensitive dual inversion-recovery (PS-DIR) black-blood imaging technique (24) recently has been developed to address this challenge. PS-DIR relaxes the constraints related to blood signal nulling time and the period of minimal myocardial motion and thus enables black-blood imaging to be less sensitive to imaging time parameters.…”

Section: Cardiac Imaging: Coronary Vessel Wall 30-t Mr Imagingmentioning

confidence: 99%

“…The PS-DIR sequence is modified in this work to acquire several successive cine phases or frames, as shown in Figure 1, B. In this TRAPD approach, each cine frame is then reconstructed into a PS-DIR signpreserved magnitude image (24).…”

Section: Advances In Knowledgementioning

confidence: 99%

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Coronary Vessel Wall 3-T MR Imaging with Time-resolved Acquisition of Phase-Sensitive Dual Inversion-Recovery (TRAPD) Technique: Initial Results in Patients with Risk Factors for Coronary Artery Disease

Abd‐Elmoniem

Gharib²,

Pettigrew³

2012

Radiology

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Purpose:To develop a technique for time-resolved acquisition of phasesensitive dual-inversion recovery (TRAPD) coronary vessel wall magnetic resonance (MR) images, to investigate the success rate in coronary wall imaging compared with that of single-frame imaging, and to assess vessel wall thickness in healthy subjects and subjects with risk factors for coronary artery disease (CAD). Materials andMethods:Thirty-eight subjects (12 healthy subjects, 26 subjects with at least one CAD risk factor) provided informed consent for participation in this institutional review board-approved and HIPAA-compliant study. The TRAPD coronary vessel wall imaging sequence was developed and validated with a flow phantom. Time-resolved coronary artery wall images at three to five cine phases were obtained in all subjects. Qualitative and quantitative comparisons were made between TRAPD and conventional single-image wall measurements. Measurement reproducibility also was assessed. Statistical analysis was performed for all comparisons. Results:The TRAPD sequence successfully restored the negative polarity of lumen signal and enhanced lumen wall contrast on the cine images of the flow phantom and in all subjects. Use of three to five frames increased the success rate of acquiring at least one image of good to excellent quality from 76% in single-image acquisitions to 95% with the TRAPD sequence. The difference in vessel wall thickness between healthy subjects and subjects with CAD risk factors was significant (P , .05) with the TRAPD sequence (1.07 vs 1.46 mm, respectively; 36% increase) compared with single-frame dual inversion-recovery imaging (1.24 vs 1.55 mm, respectively; 25% increase). Intraobserver, interobserver, and interexamination agreement for wall thickness measurement were 0.98, 0.97, and 0.92, respectively. Conclusion:TRAPD imaging of coronary arteries improved arterial wall visualization and quantitative assessment by increasing the success rate of obtaining good-to excellent-quality images and sections orthogonal to the longitudinal axis of the vessel. This also resulted in vessel wall thickness measurements that show a more distinct difference between healthy subjects and those with CAD risk factors.q RSNA, 2012 Supplemental material: http://radiology.rsna.org/lookup /suppl

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Section: Resultsmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Section: Cardiac Imaging: Coronary Vessel Wall 30-t Mr Imagingmentioning

confidence: 99%

Section: Advances In Knowledgementioning

confidence: 99%

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Coronary Vessel Wall 3-T MR Imaging with Time-resolved Acquisition of Phase-Sensitive Dual Inversion-Recovery (TRAPD) Technique: Initial Results in Patients with Risk Factors for Coronary Artery Disease

Abd‐Elmoniem

Gharib²,

Pettigrew³

2012

Radiology

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“…Because imaging at multiple time points after dual inversion is thus enabled, the restriction for imaging at TI* no longer exists and more time-efficient acquisition schemes may be implemented. 17 However, the extraction of phase information is challenging [17][18][19] and often requires the acquisition of an additional reference image, [18][19][20][21] the use of local region growing algorithms, 16 phase modeling, 22 or image statistics. 23 In this article, a novel extension of PS-DIR for carotid vessel wall imaging is proposed that exploits the statistical distribution of the phase signal after DIR 23 to automatically segment carotid lumens and suppress their residual blood signal.…”

mentioning

confidence: 99%

Phase-Sensitive Dual-Inversion Recovery for Accelerated Carotid Vessel Wall Imaging

Bonanno

Brotman

Stuber³

2015

Investigative Radiology

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Coronary artery wall imaging

Keegan

2014

J. Magn. Reson. Imaging

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Like X-Ray contrast angiography, MR coronary angiograms show the vessel lumens rather than the vessels themselves. Consequently, outward remodeling of the vessel wall, which occurs in subclinical coronary disease before luminal narrowing, cannot be seen. The current gold standard for assessing the coronary vessel wall is intravascular ultrasound, and more recently, optical coherence tomography, both of which are invasive and use ionizing radiation. A noninvasive, low-risk technique for assessing the vessel wall would be beneficial to cardiologists interested in the early detection of preclinical disease and for the safe monitoring of the progression or regression of disease in longitudinal studies. In this review article, the current state of the art in MR coronary vessel wall imaging is discussed, together with validation studies and recent developments.

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Phase-sensitive black-blood coronary vessel wall imaging

Cited by 15 publications

References 47 publications

Coronary Vessel Wall 3-T MR Imaging with Time-resolved Acquisition of Phase-Sensitive Dual Inversion-Recovery (TRAPD) Technique: Initial Results in Patients with Risk Factors for Coronary Artery Disease

Coronary Vessel Wall 3-T MR Imaging with Time-resolved Acquisition of Phase-Sensitive Dual Inversion-Recovery (TRAPD) Technique: Initial Results in Patients with Risk Factors for Coronary Artery Disease

Phase-Sensitive Dual-Inversion Recovery for Accelerated Carotid Vessel Wall Imaging

Coronary artery wall imaging

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