Phase-sensitive X-ray imaging of synovial joints

Li, Jun; Zhong, Zhong; Connor, Dean M.; Mollenhauer, Jorgen; Muehleman, Carol

doi:10.1016/j.joca.2009.03.005

Cited by 36 publications

(27 citation statements)

References 24 publications

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“…DEI images obtained with X-ray tube sources do not differ significantly from visual inspection (only possible with surgery or post-mortem) in their ability to grade cartilage damage [19,20]. In CT mode, DEI can visualize both bone and soft tissue with high contrast in an intact cadaveric human knee joint [21] using an absorbed radiation dose equal to that of a clinical image (Fig. 2).…”

Section: Proof-of-principle Dei Studiesmentioning

confidence: 99%

Diffraction-Enhanced Imaging

Connor

Zhong

2014

Curr Radiol Rep

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Diffraction-enhanced imaging (DEI), sometimes referred to as analyzer-based imaging, is an emerging phase contrast X-ray imaging modality that generates exquisite soft tissue contrast at a vastly reduced absorbed radiation dose relative to absorption-based radiography for imaging applications, which include mammography and assessment of cartilage and lung damage. In this review, we will summarize recent advances in the field of DEI. These include assessment of liver fibrosis, evaluation of the orientation and degree of anisotropy in bone microarchitecture, and assessment of emphysema. We will summarize the state of the clinical translation of DEI and discuss barriers to the clinical translation of DEI and potential ways to overcome these barriers.Keywords Diffraction-enhanced imaging (DEI) Á Analyzer-based imaging (ABI) Á Multiple image radiography (MIR) Á Phase contrast imaging Á Radiography Á X-ray vector radiography Á X-ray tensor tomography

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Section: Proof-of-principle Dei Studiesmentioning

confidence: 99%

Diffraction-Enhanced Imaging

Connor

Zhong

2014

Curr Radiol Rep

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“…Cartilage within knee, ankle, and shoulder joints can be observed and characterized in refraction images of both radiographs and CT. 11,39,[41][42][43][44] A number of groups have used PC imaging to analyze differences in cartilage structure between healthy and arthritic joints. In absorptionbased imaging, osteoarthritis is diagnosed only in the final stage of arthritis when deformation of the joint can be clearly identified due to the close proximity of bones (i.e., the diagnosis is based on the ability to image calcified tissues and not cartilage).…”

Section: Orthopedic Tissuesmentioning

confidence: 99%

Potential for Imaging Engineered Tissues with X-Ray Phase Contrast

Appel

Anastasio

Brey

2011

Tissue Engineering Part B: Reviews

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“…Over the past few decades, phase contrast X-ray imaging has been under rapid development and various X-ray phase contrast methods have been implemented, including X-ray interferometry (6, 7), analyzer-based (or diffraction-enhanced) imaging (10, 11), propagation-based imaging (12, 13), grating-based imaging (14, 15), and grating noninterferometric methods (16). A large number of X-ray phase contrast imaging results has been reported on both technical developments and biomedical applications (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). In vitro and in vivo biomedical studies have focused on demonstrating high diagnostic significance of PCI images in a wide range of pathologies related to breast (8), joint and cartilage (17), lung (18), and central nervous system (19).…”

mentioning

confidence: 99%

“…Clinical trials have also been performed in PCI mammography (20). Furthermore, the development of advanced optics for the use of 50-80 keV (instead of 15-30 keV) X-rays has dramatically increased the sample size under study in PCT (8,17). However, presently two of the major challenges prevent PCT from becoming an in vivo imaging tool for clinical application.…”

mentioning

confidence: 99%

“…A large number of X-ray phase contrast imaging results has been reported on both technical developments and biomedical applications (6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20). In vitro and in vivo biomedical studies have focused on demonstrating high diagnostic significance of PCI images in a wide range of pathologies related to breast (8), joint and cartilage (17), lung (18), and central nervous system (19). Clinical trials have also been performed in PCI mammography (20).…”

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confidence: 99%

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High-resolution, low-dose phase contrast X-ray tomography for 3D diagnosis of human breast cancers

Zhao

Brun

Coan

et al. 2012

Proc. Natl. Acad. Sci. U.S.A.

179

149

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Mammography is the primary imaging tool for screening and diagnosis of human breast cancers, but ∼10-20% of palpable tumors are not detectable on mammograms and only about 40% of biopsied lesions are malignant. Here we report a high-resolution, low-dose phase contrast X-ray tomographic method for 3D diagnosis of human breast cancers. By combining phase contrast X-ray imaging with an image reconstruction method known as equally sloped tomography, we imaged a human breast in three dimensions and identified a malignant cancer with a pixel size of 92 μm and a radiation dose less than that of dual-view mammography. According to a blind evaluation by five independent radiologists, our method can reduce the radiation dose and acquisition time by ∼74% relative to conventional phase contrast X-ray tomography, while maintaining high image resolution and image contrast. These results demonstrate that high-resolution 3D diagnostic imaging of human breast cancers can, in principle, be performed at clinical compatible doses.radiation dose reduction | iterative algorithm | analyzer based imaging M ammography is a widely used imaging technique for early detection of human breast cancers. Although more advanced technologies such as digital mammography have been developed to improve its image quality (1), there are three potential risks associated with mammography. First, mammograms miss up to 20% of breast cancers that are present during the time of screening (2). Second, in some cases mammograms appear abnormal, but no breast cancers are actually present (3). Third, repeated mammography examinations have the potential of causing cancers (4). Dedicated breast computed tomography (CT) can reduce some of these risks, but its spatial resolution (∼400 μm) is mainly limited by the X-ray dose deliverable to the radiationsensitive human breast and its detection of microcalcifications is inferior to mammography (5). Furthermore, some tumors are not visible in CT because its image contrast is based on the X-ray absorption coefficient and is intrinsically low between tumors and normal tissues. A very promising approach to significantly improve the image resolution, image contrast and detectability is the use of phase contrast x-ray tomography (PCT) (6-8) (Materials and Methods). Compared with absorption-based CT, PCT is sensitive to the refraction (i.e., "phase shift") of X-rays in matter. In soft tissues, phase variations can be two to three orders of magnitude larger than the absorption ones (9), and thus an increased image contrast can be achieved. Over the past few decades, phase contrast X-ray imaging has been under rapid development and various X-ray phase contrast methods have been implemented, including X-ray interferometry (6, 7), analyzer-based (or diffraction-enhanced) imaging (10, 11), propagation-based imaging (12, 13), grating-based imaging (14, 15), and grating noninterferometric methods (16). A large number of X-ray phase contrast imaging results has been reported on both technical developments and biomedical applications ...

show abstract

Phase-sensitive X-ray imaging of synovial joints

Cited by 36 publications

References 24 publications

Diffraction-Enhanced Imaging

Diffraction-Enhanced Imaging

Potential for Imaging Engineered Tissues with X-Ray Phase Contrast

High-resolution, low-dose phase contrast X-ray tomography for 3D diagnosis of human breast cancers

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