2021
DOI: 10.3390/ijms221910267
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Phase Separation and Mechanical Forces in Regulating Asymmetric Cell Division of Neural Stem Cells

Abstract: Asymmetric cell division (ACD) of neural stem cells and progenitors not only renews the stem cell population but also ensures the normal development of the nervous system, producing various types of neurons with different shapes and functions in the brain. One major mechanism to achieve ACD is the asymmetric localization and uneven segregation of intracellular proteins and organelles into sibling cells. Recent studies have demonstrated that liquid-liquid phase separation (LLPS) provides a potential mechanism f… Show more

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Cited by 13 publications
(6 citation statements)
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“…Presented in the cells, biomolecules undergo liquid-liquid phase separation (LLPS), forming liquid-like droplets called membraneless organelles. Biomolecules in the dense phase are highly dynamic and able to freely exchange with their surroundings due to the absence of physical separation by the membrane [127]. Therefore, phase separation is sensitive to the changes in endogenous or exogenous factors including stress response, signal transduction, and posttranslational modifications [128].…”
Section: Phase Separation and Yap/taz Pathwaymentioning
confidence: 99%
“…Presented in the cells, biomolecules undergo liquid-liquid phase separation (LLPS), forming liquid-like droplets called membraneless organelles. Biomolecules in the dense phase are highly dynamic and able to freely exchange with their surroundings due to the absence of physical separation by the membrane [127]. Therefore, phase separation is sensitive to the changes in endogenous or exogenous factors including stress response, signal transduction, and posttranslational modifications [128].…”
Section: Phase Separation and Yap/taz Pathwaymentioning
confidence: 99%
“…To do so, a multitude of plausible strategies to regulate their population size have been proposed, such as competition for niche access [3][4][5][6], competition for niche signals [6][7][8][9], mechanical feedback [10][11][12], or feedback from the more differentiated populations [13][14][15]. However, it is still unclear how to distinguish the presence or absence of different regulation strategies from snapshots of the stem cell populations or clonal sub-populations, which are what can often be measured experimentally.…”
Section: Introductionmentioning
confidence: 99%
“…This feature permits a simplified profiling on the LLPS process since intermolecular interactions for the specific component can be excluded. Among single-molecular studies, few investigations focus on the LLPS condensates from a mechanical perspective. Given that LLPS condensates partake in many mechanobiological processes such as chromosomal segregation during cell division , and transportation inside cells, , it becomes an urgent call to evaluate the condensates from mechanical aspects.…”
Section: Introductionmentioning
confidence: 99%