2012
DOI: 10.1007/s10847-012-0110-3
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Phase solubility and FTIR-ATR studies of idebenone/sulfobutyl ether β-cyclodextrin inclusion complex

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Cited by 39 publications
(33 citation statements)
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“…FTIR of the inclusion complex KD showed that CAR band (which appeared at 3344.1 cm −1 corresponding to N-H stretching vibration) disappeared and completely overlapped with cyclodextrin's hydroxyl group. The decreased intensity of other bands reveals the formation of new chemical bonds between CAR and HPβCD (39). These findings suggest that CAR is included in HPβCD cavity through the weak secondary valence force between the N-H group of CAR and hydrogen atom of HPβCD (40).…”
Section: Characterization Of Inclusion Complex and Solid Dispersionsmentioning
confidence: 91%
“…FTIR of the inclusion complex KD showed that CAR band (which appeared at 3344.1 cm −1 corresponding to N-H stretching vibration) disappeared and completely overlapped with cyclodextrin's hydroxyl group. The decreased intensity of other bands reveals the formation of new chemical bonds between CAR and HPβCD (39). These findings suggest that CAR is included in HPβCD cavity through the weak secondary valence force between the N-H group of CAR and hydrogen atom of HPβCD (40).…”
Section: Characterization Of Inclusion Complex and Solid Dispersionsmentioning
confidence: 91%
“…This demonstrates that the drug remains intact and that there is no interaction between the drug and the cyclodextrin. On the contrary, when compared to that of the physical mixture, the spectrum of the inclusion complex exhibits relevant changes in center-frequencies, intensities, and widths of the characteristic absorption peaks, revealing the formation of a new chemical bond between the drug and the cyclodextrin [44].…”
Section: Fourier-transform Infrared Spectroscopymentioning
confidence: 96%
“…Actually, since O-H and C-H stretching vibrations appeared partially overlapped, it was first of all necessary to fit the whole range extending from 3800 to 2700 cm -1 and then to subtract from the total fit the contributions due to symmetric and antisymmetric methyl stretches. Then, more detailed fit was performed only for the O-H stretching spectral range where, as previously demonstrated [32,49,50], all the contributions coming from primary and secondary OH groups of SBE-b-CyD, from the pure drugs, and from interstitial and intracavity H 2 O molecules overlap. According to a well-established method [33], after the second derivative computation of the experimental spectra for obtaining a first indication of the number of each band component, six in our case, with an approximate position of their maxima, taken by looking at the minima in the second derivative profiles, deconvolution into Voigt peaks was applied (see Figs.…”
Section: Characterization In Solid Statementioning
confidence: 99%
“…The main results, i.e. centre-frequency and percentage intensity of each subband, are reported in Table 1, together with an assignment of each contribution, based on previous works on similar systems [32,[49][50][51].…”
Section: Characterization In Solid Statementioning
confidence: 99%
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