Phase transformation considerations during process development and manufacture of solid oral dosage forms

Zhang, Geoff G. Z.; Law, Devalina; Schmitt, Eric A.; Qiu, Yihong

doi:10.1016/j.addr.2003.10.009

Cited by 402 publications

(290 citation statements)

References 83 publications

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“…In the literature, the difference in the solid phases is responsible for the differences in the solubility of the drugs, for example an amorphous substance is more hygroscopic and more reactive than a crystalline substance due to its more raised thermodynamic activity [11]. The studies by the X-ray are very useful in order to determine these properties.…”

Section: Rx Spectral Studiesmentioning

confidence: 99%

Investigation of Cyclodextrin Inclusion Compounds Using FT-IR, SEM and X-Ray Diffraction

Zidane¹,

Maïza²,

Bouleghlem³

et al. 2016

IJCEA

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Abstract-The prepared complexes of inclusion are characterized by IR where we have deduced the presence of new liaisons, this we permitted to say that, it has a formation of a new bands and we also concluded that the intensity of absorption of the majority of the frequencies are moved in the complexes which are weaker than in pure Tramadol. In the literature an amorphous material is more reactive than a crystalline one and as consequence amorphous materials are considered more hygroscopic when compared to crystalline solids. The results obtained by X-rays shows a crystalline semi profile for the complexes prepared by the three methods contrary to Tramadol and β-CD which present a crystalline profile. Modification of crystals and powder can be also observed by SEM and assumed as a proof of the formation of new inclusion complex.

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Section: Rx Spectral Studiesmentioning

confidence: 99%

Investigation of Cyclodextrin Inclusion Compounds Using FT-IR, SEM and X-Ray Diffraction

Zidane¹,

Maïza²,

Bouleghlem³

et al. 2016

IJCEA

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show abstract

“…While control of formulation (specifically excipient or polymeric components) is shown to influence pharmaceutical crystallisation (Trasi et al 2012), Melendez et al (2008) hypothesise that the control of the inkjet printing parameters may lead to selectivity of polymorphs. This is reinforced by the work of Zhang et al (2004) who examined the interconversion among polymorphs due to processing techniques.…”

Section: Nozzle Flow Influencesmentioning

confidence: 99%

Inkjet printing for pharmaceutics – A review of research and manufacturing

Daly

Harrington

Martin

et al. 2015

International Journal of Pharmaceutics

271

185

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Abstract:Global regulatory, manufacturing and consumer trends are driving a need for change in current pharmaceutical sector business models, with a specific focus on the inherently expensive research costs, high-risk capital-intensive scale-up and the traditional centralised batch manufacturing paradigm. New technologies, such as inkjet printing, are being explored to radically transform pharmaceutical production processing and the end-to-end supply chain. This review provides a brief summary of inkjet printing technologies and their current applications in manufacturing before examining the business context driving the exploration of inkjet printing in the pharmaceutical sector. We then examine the trends reported in the literature for pharmaceutical printing, followed by the scientific considerations and challenges facing the adoption of this technology. We demonstrate that research activities are highly diverse, targeting a broad range of pharmaceutical types and printing systems. To mitigate this complexity we show that by categorising findings in terms of targeted business models and Active Pharmaceutical Ingredient (API) chemistry we have a more coherent approach to comparing research findings and can drive efficient translation of a chosen drug to inkjet manufacturing.

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“…The extent of conversion is dependent on the relative stability of the polymorphs and kinetic factors. Moreover, these crystal structures can have different chemical and physical properties (6). Nevertheless, the crucial properties are dissolution, bioavailability and subsequently therapeutic effectiveness of the drugs.…”

Section: Introductionmentioning

confidence: 99%

“…Generally, the polymorphic form of a drug can transform to a more stable form during storage and manufacturing process, such as drying, milling, and compaction (5,6). The extent of conversion is dependent on the relative stability of the polymorphs and kinetic factors.…”

Section: Introductionmentioning

confidence: 99%

“…Nevertheless, the crucial properties are dissolution, bioavailability and subsequently therapeutic effectiveness of the drugs. Typically, the metastable or thermodynamically instable forms exhibit best solubility and bioavailability (2,6). However, the most stable polymorphic form is often selected for pharmaceutical development based on the minimal potential for conversion to other polymorphic forms and on its greater chemical stability.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Use of Drifts and PLS for the Determination of Polymorphs of Piroxicam Alone and in Combination with Pharmaceutical Excipients: A Technical Note

2008

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Phase transformation considerations during process development and manufacture of solid oral dosage forms

Cited by 402 publications

References 83 publications

Investigation of Cyclodextrin Inclusion Compounds Using FT-IR, SEM and X-Ray Diffraction

Investigation of Cyclodextrin Inclusion Compounds Using FT-IR, SEM and X-Ray Diffraction

Inkjet printing for pharmaceutics – A review of research and manufacturing

Use of Drifts and PLS for the Determination of Polymorphs of Piroxicam Alone and in Combination with Pharmaceutical Excipients: A Technical Note

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