Phase Transformation of Biphasic Granules of Gypsum and Carbonated Apatite at Low Temperatures

Abstract

The purpose of this study was to prepare biphasic granules containing gypsum and carbonated apatite at low temperatures. The biphasic granules were prepared using dissolution-precipitation technique at three different temperatures 30°C, 40°C and 50°C. Characterization of the biphasic granules was determined by multiple analytical methods such as X-ray Diffraction (XRD), Scanning Electron Microscopy (SEM), Fourier Transform Infra-red (FTIR), and CHN Analysis. The obtained granules were determined by XRD as biphasic granules containing bone apatite and gypsum. The cross-section of biphasic granules was observed by SEM. The formed bone apatite was identified as B-Type carbonated apatite using FTIR The carbonate content in biphasic granules fabricated at 30°C, 40°C and 50°C were recorded by CHN analysis as 5.0 wt%, 6.1 wt% and 6.25 wt%, respectively.

Osteogenesis and Degradability of Bioresorbable Biphasic Gypsum-Carbonated Apatite Granules for Bone Tissue Engineering

“…Fig. 2 ions, which were available in the aqueous solution and precipitated to form carbonated apatite [6]. Key Engineering Materials Vol.…”

“…Calcium sulfate (CS) is a rapidly resorbable and biocompatible bone substitute with superior bone-regeneration and angiogenic effects [5] was used as a starting material of the BPG. However, CS bone grafting alone was reported to face problem with too fast dissolution rate which results the material to be lost in defect site before the completion of tissue repair [6]. Therefore, we have developed a combination of a fast resorption rate (more soluble); gypsum and a slow resorption rate (more stable); carbonated apatite at low temperature using dissolution-precipitation technique to overcome the resorption issue at the specific bone defect.…”