We consider a clustering problem where we observe feature vectors Xi ∈ R p , i = 1, 2, . . . , n, from K possible classes. The class labels are unknown and the main interest is to estimate them. We are primarily interested in the modern regime of p n, where classical clustering methods face challenges.We propose Influential Features PCA (IF-PCA) as a new clustering procedure. In IF-PCA, we select a small fraction of features with the largest Kolmogorov-Smirnov (KS) scores, obtain the first (K − 1) left singular vectors of the post-selection normalized data matrix, and then estimate the labels by applying the classical k-means procedure to these singular vectors. In this procedure, the only tuning parameter is the threshold in the feature selection step. We set the threshold in a data-driven fashion by adapting the recent notion of Higher Criticism. As a result, IF-PCA is a tuning-free clustering method.We apply IF-PCA to 10 gene microarray data sets. The method has competitive performance in clustering. Especially, in three of the data sets, the error rates of IF-PCA are only 29% or less of the error rates by other methods. We have also rediscovered a phenomenon on empirical null by Efron (2004) on microarray data.With delicate analysis, especially post-selection eigen-analysis, we derive tight probability bounds on the Kolmogorov-Smirnov statistics and show that IF-PCA yields clustering consistency in a broad context. The clustering problem is connected to the problems of sparse PCA and low-rank matrix recovery, but it is different in important ways. We reveal an interesting phase transition phenomenon associated with these problems and identify the range of interest for each. * Supported in part by NSF grants DMS-1208315 and DMS-1513414. MSC 2010 subject classifications: Primary 62H30, 62G32; secondary 62E20, 62P10.