Phemphigus vulgaris an autoimmune acantholysis: a case report

Abstract

<p class="abstract">Pemphigus vulgaris is a rare chronic autoimmune skin disease characterized by a flaccid blister filled with clear fluid that arises on the skin or an erythematous base. The keratinocytes separated by the desmoglein present on the desmosomes which clinically manifests as fluid-filled blisters on the skin. We present pemphigus vulgaris with an unknown cause but good recovery after the management with monoclonal antibodies and corticosteroids in a 30-year-old male patient who came to the hospital with complaints of blisters on the epithelial layers of skin on the face and oral mucosa.</p>

Battling Blistering: A Case Report on Pemphigus Vulgaris

“…Pemphigus is a group of potentially life-threatening disorders that cause blistering of the skin and mucous membranes, characterized by acantholysis (loss of adhesion between keratinocytes) [5]. Pemphigus vulgaris, specifically, is caused by autoantibodies targeting keratinocyte proteins called desmogleins.…”