Phenacetin and Renal Damage at a Swedish Factory

Analgesic use and the risk for progression of chronic kidney disease

“…Since the first report in the 1950s linking chronic analgesic use and CKD,16 several studies have been published which have suggested the possibility of an association. The strongest evidence pertains to phenacetin 2, 8. However, epidemiologic evidence concerning the relationship between other analgesics and renal dysfunction is conflicting.…”

“…Chronic use of analgesics has long been linked to kidney disease. Initially, phenacetin was identified as the responsible agent and was withdrawn from the market 2. The evidence for other analgesics, such as acetaminophen, aspirin, and conventional non‐steroidal anti‐inflammatory drugs (NSAIDs), is less clear.…”

Analgesics use and ESRD in younger age: a case-control study

“…The publications by Spühler et al [ 1 ], Dubach et al [ 2 ] and Zollinger [ 3 ] five decades ago on the relationship between kidney damage and phenacetin ultimately led to the recognition of a causal relation between the two. This was supported by the experience in the Swedish factory Husqvarna [ 4 ]. Many epidemiological studies and review papers contributed to this view.…”

Kinetic and Isotherm Studies of the Adsorption Phenacetin onto Two Copper Porous Coordination Compounds: Nonlinear Regression Analysis

“…However, the long-term and chronic consumption of phenacetin led to several toxicological complications ranging from nephrotoxicity to carcinogenicity [4]. e carcinogenicity was observed in the urinary tract and renal pelvis [5]. As a result of these severe complications, phenacetin and drugs containing phenacetin were withdrawn from the market by the order of the U.S. Food and Drug Administration in 1983 [6].…”