Phenalenyl based platinum anticancer compounds with superior efficacy: design, synthesis, characterization, and interaction with nuclear DNA

Dutta, Pradip Kumar; Kumari, Smita; Paulraj, Justin; Sharma, Rohan; Vijaykumar, Gonela; Das, Hari Sankar; Sreejyothi, P; Sil, Swagata; Mandal, Swadhin K.; Sengupta, Aniruddha; Sarkar, Arindam

doi:10.1039/d0nj06229d

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“…In addition, the field of B-doped phenalenyl moieties is currently an emerging area which will gain considerable attention to the organic synthetic, physical, and spectroscopic chemist in upcoming decades. ii) Medicinal chemistry: A preliminary investigation on the anticancer drug design with phenalenyl ligand exhibited promising anti-cancer activity. ,, This approach of anti-cancer drug design with phenalenyl molecules will be attractive to medicinal chemistry as the fluorescence property of phenalenyl based molecules can act as a probe to visualize them in vivo enabling mechanistic understanding. iii) Transition metal-free redox/photo redox catalysis: Currently, it has been found that the phenalenyl based molecule can mimic the transition metal behavior in designing transition metal-free catalysis.…”

Section: Summary and Future Outlookmentioning

confidence: 99%

Phenalenyl Radical: Smallest Polycyclic Odd Alternant Hydrocarbon Present in the Graphene Sheet

Ahmed

Mandal

2022

Chem. Rev.

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Phenalenyl, a zigzag-edged odd alternant hydrocarbon unit can be found in the graphene nanosheet. Hückel molecular orbital calculations indicate the presence of a nonbonding molecular orbital (NBMO), which originates from the linear combination of atomic orbitals (LCAO) arising from 13 carbon atoms of the phenalenyl molecule. Three redox states (cationic, neutral radical, and anionic) of the phenalenyl-based molecules were attributed to the presence of this NBMO. The cationic state can undergo two consecutive reductions to result in neutral radical and anionic states, stepwise, respectively. The phenalenyl-based radicals were found as crucial building blocks and attracted the attention of various research fields such as organic synthesis, material science, computation, and device physics. From 2012 onward, a strategy was devised using the cationic state of phenalenyl-based molecules and in situ generated phenalenyl radicals, which created a new domain of catalysis. The in situ generated phenalenyl radicals were utilized for the single electron transfer (SET) process resulting in redox catalysis. This emerging range of applications rejuvenates the more than six decades-old phenalenyl chemistry. This review captures such developments ranging from fundamental understanding to multidirectional applications of phenalenyl-based radicals.

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Section: Summary and Future Outlookmentioning

confidence: 99%

Phenalenyl Radical: Smallest Polycyclic Odd Alternant Hydrocarbon Present in the Graphene Sheet

Ahmed

Mandal

2022

Chem. Rev.

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Phenalenyl based platinum anticancer compounds with superior efficacy: design, synthesis, characterization, and interaction with nuclear DNA

Abstract: New and efficacious phenalenyl based Pt(ii) compounds have been used to design an “easy to use tool” for mechanistic understanding.

Cited by 1 publication

References 46 publications

Phenalenyl Radical: Smallest Polycyclic Odd Alternant Hydrocarbon Present in the Graphene Sheet

Phenalenyl Radical: Smallest Polycyclic Odd Alternant Hydrocarbon Present in the Graphene Sheet

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