2009
DOI: 10.2174/157340709787580928
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Phenanthroindolizidines and Phenanthroquinolizidines: Promising Alkaloids for Anti-Cancer Therapy

Abstract: The phenanthroindolizidine and phenanthroquinolizidine alkaloids, typified by tylophorine and cryptopleurine, are a family of plant-derived small molecules with significant therapeutic potential. The plant extracts have been used in herbal medicine and the isolated compounds have displayed a range of promising therapeutic activity such as anti-ameobicidal, anti-viral, anti-inflammatory and anti-cancer activity. Despite their therapeutic protential, no compounds in this class have fully passed clinical trials. … Show more

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Cited by 132 publications
(96 citation statements)
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“…We further demonstrated the utility of this methodology in the enantioselective total synthesis of ( S )-(+)-tylophorine ( 46 ), a promising anti-cancer compound with excellent in vitro activity in a broad range of cancer cell lines [37,38]. Our synthesis (Scheme 8) of tylophorine is 8 steps from commercially available starting material, making this enantioselective synthesis one of the shorter preparations of this compound [38].…”
Section: Copper(ii)-promoted and Catalyzed Intramolecular Alkene Cmentioning
confidence: 99%
See 1 more Smart Citation
“…We further demonstrated the utility of this methodology in the enantioselective total synthesis of ( S )-(+)-tylophorine ( 46 ), a promising anti-cancer compound with excellent in vitro activity in a broad range of cancer cell lines [37,38]. Our synthesis (Scheme 8) of tylophorine is 8 steps from commercially available starting material, making this enantioselective synthesis one of the shorter preparations of this compound [38].…”
Section: Copper(ii)-promoted and Catalyzed Intramolecular Alkene Cmentioning
confidence: 99%
“…Our synthesis (Scheme 8) of tylophorine is 8 steps from commercially available starting material, making this enantioselective synthesis one of the shorter preparations of this compound [38]. …”
Section: Copper(ii)-promoted and Catalyzed Intramolecular Alkene Cmentioning
confidence: 99%
“…The phenanthroindolizidine alkaloids, such as tylophorine, tylocrebrine, and tylophorinine, are characteristic constituents of Cynanchum, Pergularia, Tylophora, and other genera of the Asclepiadaceae. These phenanthroindolizidines have activities against leukemia, asthma, anaphylaxis, other inflammations and bacterial infection (Bhutani et al, 1987;Chemler, 2009;Gopalakrishnan et al, 1980), as well as against cancer Li et al, 2001b;Staerk et al, 2002;Yang et al, 2006Yang et al, , 2007a. The herbal plant Tylophora indica has been traditionally used in India as a folk remedy to treat bronchial asthma, bronchitis, rheumatism, and dermatitis (Li et al, 2001a).…”
Section: Introductionmentioning
confidence: 99%
“…Many of these alkaloids possess significant anticancer activity (both in vitro and in vivo) as well as anti-inflammatory, antiameobicidal, and antiviral activities [2]. The significant antineoplastic activities of many phenanthroindolizidines have attracted the interest of quite a number of medicinal chemists and pharmacologists since 1935 when the first phenanthroindolizidine alkaloid, tylophorine, was isolated from Tylophora indica [3].…”
Section: Introductionmentioning
confidence: 99%