Phencyclidine False Positive Result Induced by LamoTRIgine on the PROFILE-V MEDTOXScan Drugs of Abuse Test System

Murphy, Corinne M.; Dyer, Rebekah P.; McAllister, Matthew W.

doi:10.1016/j.jen.2019.01.015

Cited by 2 publications

(3 citation statements)

References 3 publications

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“…Regarding the inpatient portion of our study, the primary limitation was our reliance on urine toxicology screening with no confirmatory testing. Phencyclidine urine tests can have false positives resulting from cross-reactivity with many drugs such as lamotrigine, desvenlafaxine, tramadol, dextromethorphan, and diphenhydramine, but the relatively high prevalence of PCP use in this sample increases the positive predictive value of urine testing 40–42 . This study likely underestimates the number of patients who infrequently use PCP given its reliance on urine toxicology screening with a detection window of approximately 8 days.…”

Section: Limitationsmentioning

confidence: 85%

“…Phencyclidine urine tests can have false positives resulting from cross-reactivity with many drugs such as lamotrigine, desvenlafaxine, tramadol, dextromethorphan, and diphenhydramine, but the relatively high prevalence of PCP use in this sample increases the positive predictive value of urine testing. [40][41][42] This study likely underestimates the number of patients who infrequently use PCP given its reliance on urine toxicology screening with a detection window of approximately 8 days. As mentioned previously, we were also unable to estimate prevalence of PCP use disorder.…”

Section: Limitationsmentioning

confidence: 96%

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Phencyclidine Positivity on Urine Drug Screening in Patients Treated for Alcohol Withdrawal on a Dual-diagnosis Medically Assisted Withdrawal Unit

Wang,

Dore,

Weleff

et al. 2023

J Addict Med

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Objectives Little contemporary research has explored phencyclidine (PCP) use in people with alcohol use disorder. Therefore, we sought to determine the prevalence of PCP positivity on urine toxicology screening among patients admitted for alcohol withdrawal, identify correlates of PCP positivity, and investigate PCP positivity's relationship to length of stay (LOS) and risk of facility readmission. Methods This was a retrospective study of patients admitted to a dual-diagnosis medically assisted withdrawal unit for alcohol withdrawal from 2014 to 2019. Univariate tests and logistic regression were used to investigate potential correlates of PCP positivity on admission toxicology screening (primary outcome). Multivariable linear regression models and survival analyses analyzing LOS and risk of readmission (secondary outcomes) were also developed. Results Ninety of 3731 patients (2.4%) screened positive for PCP. There were significant associations on univariate testing between PCP positivity and age, race, homeless status, and urine toxicology positivity for amphetamines, benzodiazepines, barbiturates, cocaine, tetrahydrocannabinol, and oxycodone. On multivariate logistic regression, only tetrahydrocannabinol, barbiturates, and cocaine positivity were associated with PCP positivity. Multivariate logistic regression and survival analysis found no statistically significant associations between PCP positivity and LOS or risk of readmission. Conclusions This study provides rare analysis of contemporary data on PCP use among patients undergoing medically assisted alcohol withdrawal. Phencyclidine positivity was uncommon, but use appears considerably higher among this patient population than the general population. There was no significant association between PCP positivity and LOS or readmission risk.

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Section: Limitationsmentioning

confidence: 85%

Section: Limitationsmentioning

confidence: 96%

Phencyclidine Positivity on Urine Drug Screening in Patients Treated for Alcohol Withdrawal on a Dual-diagnosis Medically Assisted Withdrawal Unit

Wang,

Dore,

Weleff

et al. 2023

J Addict Med

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“…Recent publications in JEN provide resources to improve emergency care relative to interpersonal violence by addressing forensic evidence collection, [8][9][10] sexual assault, 11 intimate partner violence, [12][13][14] child maltreatment, 15 firearm…”

Section: Forensic Nursing In Jenmentioning

confidence: 99%

Typology of Interpersonal Violence Model With Applications in Emergency Nursing: Forensics and Interpersonal Violence Special Issue

Castner¹

2020

Journal of Emergency Nursing

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Phencyclidine False Positive Result Induced by LamoTRIgine on the PROFILE-V MEDTOXScan Drugs of Abuse Test System

Cited by 2 publications

References 3 publications

Phencyclidine Positivity on Urine Drug Screening in Patients Treated for Alcohol Withdrawal on a Dual-diagnosis Medically Assisted Withdrawal Unit

Phencyclidine Positivity on Urine Drug Screening in Patients Treated for Alcohol Withdrawal on a Dual-diagnosis Medically Assisted Withdrawal Unit

Typology of Interpersonal Violence Model With Applications in Emergency Nursing: Forensics and Interpersonal Violence Special Issue

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