Phencyclidine injections into the dorsal hippocampus disrupt long- but not short-term memory within a spatial learning task

Kesner, Raymond P.; Dakis, Manoli

doi:10.1007/bf02246194

Cited by 41 publications

(21 citation statements)

References 27 publications

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“…Almost identical findings have been reported that posttraining intraperitoneal (ϩ)MK-801 administration or intrahippocampal injection of AP5 and phencyclidine, NMDA receptor antagonists, showed no impairment of the retention of shortterm memory and working memory. 20,21,8) In the present study, it was found that (ϩ)MK-801 potentiated the effects of muscimol on the retention of spatial working memory. Similar results have also been reported; for instance, Aversano et al 22) reported that (ϩ)MK-801 potentiated the effect of ethanol on memory consolidation in the …”

Section: Discussionsupporting

confidence: 59%

Interaction between Hippocampal .GAMMA.-Aminobutyric AcidA and N-Methyl-D-aspartate Receptors in the Retention of Spatial Working Memory in Rats

Saito

Okada

Ouwa

et al. 2010

Biological & Pharmaceutical Bulletin

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To clarify the interaction between hippocampal g g-aminobutyric acid (GABA) A receptor and N-methyl-Daspartate (NMDA) receptor in the retention of spatial working memory, the effects of muscimol, (؉)MK-801, cyclosporin A and combined use of these drugs were studied on the retention of spatial working memory in a delayed spatial win-shift (SWSh) task. Intrahippocampal injection of muscimol at a dose of 3 nmol/side caused a significant decrease in the number of correct choices and an increase in the number of across-phase errors. On the other hand, (؉)MK-801 showed no significant effect on the number of correct choices, across-phase errors and within-phase errors, even at a dose of 1.5 nmol/side; however, (؉)MK-801 1.5 nmol/side significantly potentiated the effect of muscimol observed at a dose of 3 nmol/side on the number of correct choices and across-phase errors. Cyclosporin A at a dose of 3 nmol/side, which showed no effect when used separately, significantly potentiated the effect of muscimol observed at a dose of 3 nmol/side. These results indicate that hippocampal NMDA receptors regulate the effect of spatial working memory induced by muscimol. In addition, calcineurin may be involved in muscimol-induced impairment of memory retention.

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Section: Discussionsupporting

confidence: 59%

Interaction between Hippocampal .GAMMA.-Aminobutyric AcidA and N-Methyl-D-aspartate Receptors in the Retention of Spatial Working Memory in Rats

Saito

Okada

Ouwa

et al. 2010

Biological & Pharmaceutical Bulletin

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“…Accordingly, maternal rats exhibit enhanced foraging/spatial ability in an 8-arm radial maze, and in an analog of the Morris Water Maze (viz. the dry land maze; Kesner & Dakis, 1995) in which they learn the location of a baited food well (Bodensteiner, Cain, Ray, & Hamula, 2005;Gatewood et al, 2005;Kinsley et al, 1999;Love et al, 2005;Pawluski, Walker, & Galea, 2006). Enhanced (and accurate) processing of the social surround, weighing threat against maternal aims is another ancillary maternal behavior central to successful parenting; postpartum rats performed better than NULL subjects in social learning tasks that were independent of pup or maternal cues (Fleming, Kuchera, Lee, & Winocur, 1994).…”

Section: Maternal Behavior and Neural Plasticitymentioning

confidence: 96%

Motherhood Induces and Maintains Behavioral and Neural Plasticity across the Lifespan in the Rat

et al. 2007

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Maternal behavior is multidimensional, encompassing many facets beyond the direct care of the young. Formerly unfamiliar activities are required of the mother. These include behaviors such as retrieving, grouping, crouching-over, and licking young, and protecting them against predators, together with enhancements in other behaviors, such as nest building, foraging, and aggression (inter/intra-species, predatory, etc.). When caring for young, the mother must strike a seemingly lose-lose bargain: leave the relative safety of the nest and her helpless offspring to forage for food and resources where predators await both mother and her vulnerable young, or remain entrenched and safe, thereby ensuring a slow and inexorable fate. Two predictions thus arise from this maternal cost-benefit ratio: first, there may be enhancements in behaviors on which the female relies, for example, predation and spatial ability, used for acquiring food and resources and for navigating her environment. Second, there may be reductions in the fear and anxiety inherent to the decision to leave the nest and to forage in an unforgiving environment where encounters with predators or reluctant/resistant prey await. There is overwhelming support for both hypotheses, with improvements in learning and memory accompanied by a diminution in stress responses and anxiety. The current review will examine the background for the phenomenon that is the maternal brain, and recent relevant data. In sum, the data indicate a remarkable set of changes that take place in the maternal (and, to a lesser extent, the paternal), brain, arguably, for the natural, simple but singular experience of reproduction.

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“…In this study, the animals were behaviorally tested at six, twelve, eighteen, and twenty-four months of age on a spatial learning task, which required them to remember the location of a baited food well in the dry land maze (DLM; a Morris water maze analog; Kesner and Dakis 1995). Beginning at 12 months of age, and continuing until 24 months, the animals underwent additional testing (on a so-called reversal task), which required that they ''un-learn'' the original contingency, and learn a new location for the food reward, thereby assessing the flexibility of their learning.…”

Section: Evidence For Reproductive Experiential Mediation Of Nervous mentioning

confidence: 99%

Reproductive Experience may Positively Adjust the Trajectory of Senescence

Kinsley

Franssen

Meyer

2011

Behavioral Neurobiology of Aging

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Although aging is inexorable, aging well is not. From the perspective of research in rats and complementary models, reproductive experience has significant effects; indeed, benefits, which include better-than-average cognitive skills, a slowing of the slope of decline, and a healthier brain and/or nervous system well later into life. Work from our lab and others has suggested that the events of pregnancy and parturition, collectively referred to as reproductive experience-an amalgam of hormone exposure, sensory stimulation, and offspring behavioral experience and interaction-may summate to flatten the degree of decline normally associated with aging. Mimicking the effects of an enriched environment, reproductive experience has been shown to: enhance/protect cognition and decrease anxiety well out to two-plus years; result in fewer hippocampal deposits of the Alzheimer's disease herald, amyloid precursor protein (APP); and, in general, lead to a healthier biology. Based on a suite of recent work in organisms as diverse as nematodes, flies, and mammals, the ubiquitous hormone insulin and its large family of related substances and receptors may play a major role in mediating some of the effects of RE on the parameters of aging studied thus far. We will discuss the current set of data that suggest mechanisms for successful biological and neurobiological aging, and the implications for understanding aging and senescence in their broadest terms.

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Phencyclidine injections into the dorsal hippocampus disrupt long- but not short-term memory within a spatial learning task

Cited by 41 publications

References 27 publications

Interaction between Hippocampal .GAMMA.-Aminobutyric AcidA and N-Methyl-D-aspartate Receptors in the Retention of Spatial Working Memory in Rats

Interaction between Hippocampal .GAMMA.-Aminobutyric AcidA and N-Methyl-D-aspartate Receptors in the Retention of Spatial Working Memory in Rats

Motherhood Induces and Maintains Behavioral and Neural Plasticity across the Lifespan in the Rat

Reproductive Experience may Positively Adjust the Trajectory of Senescence

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