Phenelzine use throughout pregnancy and the puerperium: Case report, review of the literature, and management recommendations

Structural Effects and Neurofunctional Sequelae of Developmental Exposure to Psychotherapeutic Drugs: Experimental and Clinical Aspects

“…However, the small sample size, the lack of description of the type of abnormalities, and the inclusion of isoniazid in the exposed group limits interpretation of these results. On the other hand, further case reports failed to demonstrate any positive significant association between the prenatal exposure to phenelzine, tranylcypromine, and moclobemide and infant malformations (Gracious and Wisner, 1997;Rybakowski, 2001).…”

“…However, no fetal adverse effects were found in the offspring of rats treated with tranylcypromine (Gracious and Wisner, 1997) or moclobemide (Rybakowski, 2001). Scant information is available regarding the teratogenic potential of MAOIs in humans.…”

Pharmacotherapy of Depression in Pregnancy

“…Reproductive safety of MAOIs such as phenelzine and tranylcypromine and Monoamine Oxidase B Inhibitors such as selegiline (46.47) cannot be inferred from the literature, as there are few publications in that area (48). Recently Reversible Inhibitors of Monoamine oxidase A (RIMAs) such as moclobemide that diminish the potential for food and drug interactions have become available in Europe.…”

Moclobemide in pregnancy

“…However, two cases have recently been described where patients took the classical MAO inhibitor, phenelzine, throughout pregnancy. With thorough monitoring and close cooperation between the psychiatrist, the obstetrician and the anesthetist, the offspring in both cases were normal; one was born spontaneously, and one with Caesarian section [2,8]. The decision of not stopping or replacing phenelzine in these cases was made due to the drugs previous efficacy in the pregnant patients described.…”