Phenobarbital in Comparison with Carbon Tetrachloride and Phenobarbital-Induced Cirrhosis in Rat Liver Regeneration

Hashimoto, Masaji; Kothary, Piyush C.; Raper, Steven E.

doi:10.1006/jsre.1998.5424

Cited by 11 publications

(9 citation statements)

References 22 publications

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“…The results was similar to that of Ismail et al (2009) who reported that relative liver weight for CCl 4 group showed significant increase as compared to the control groups. Also, the present results were similar with those of Hashimoto et al (1999), who showed that treatment with CCl 4 and phenobarbital causes liver deformity and high percentage of liver weight in the group injected with CCl 4 and fed on basal diet. However, Vernonia amygdalina pre-treatment prior to DMN administration led to a decrease of relative liver weight compared to rats administered DMN alone.…”

Section: Discussionsupporting

confidence: 92%

Dimethylnitrosamine (DMN) exposed rats: Vernonia amygdalina pre-treatment enhances immunity, hepatic and renal function

Usunobun

Okolie

2016

IJBR

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Background: The occurrence of dietary and environmental chemicals such as dimethylnitrosamine (DMN) in drinks and foods including fish and meat as well as fresh supermarket products is well established. This study evaluated protective effect of ethanolic leaf extract of Vernonia amygdalina (VAE) on liver synthetic molecules, kidney function and hematological parameters in acute dimethylnitrosamine (DMN)-induced hepatic toxicity in wistar male rats. Methods: Experimental rats divided into four groups of six rats each were used. The first group was untreated and served as control. The second group was orally administered VAE (400 mg/kg) only for seven days. The third group was pre-treated with VAE (400mg/kg) for 7 days and administered 20mg/kg DMN 24hrs after VAE pre-treatment. Rats of the fourth group were given 20mg/kg DMN alone same time with that of group 3. All rats were sacrificed 48hrs after DMN administration. Results: In rats administered 20mg/kg DMN, VAE pre-treatment at 400 mg/kg significantly increased total protein, albumin,White blood cell (WBC), Red blood cell (RBC), Hemoglobin (Hb), packed cell volume (PCV) and Platelets while it significantly decreased total bilirubin, urea and creatinine compared to DMN-alone administered rats. Conclusion: This study suggest that VAE pre-treatment exert its ameliorative effect against DMN-induced hematological and biochemical alterations possibly by preventing the decline of antioxidant defense system and could be prescribed as adjunct to dietary therapy.

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Section: Discussionsupporting

confidence: 92%

Dimethylnitrosamine (DMN) exposed rats: Vernonia amygdalina pre-treatment enhances immunity, hepatic and renal function

Usunobun

Okolie

2016

IJBR

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“…2A), corresponding with previous findings. 24 There was no relationship between amount of CCl 4 given and therapeutic antibody administered (data not shown). At sacrifice, the difference between olive oiland CCl 4 -treated rats was 70-100 g. CCl 4 -treated rats showed a 20% increase in liver-to-body weight ratio compared to control rats (Fig.…”

Section: Resultsmentioning

confidence: 90%

Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats

et al. 2004

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F ibrosis is associated with many liver diseases, including hepatitis C virus infection, iron deposition, alcohol consumption, and nonalcoholic fatty liver disease. Hepatic fibrosis results from a net increased synthesis and decreased degradation of extracellular matrix (ECM) proteins. Type I collagen is the most prevalent ECM protein deposited, 1 with activated hepatic stellate cells (HSCs) serving as the primary source. Following a fibrogenic stimulus, HSCs activate from their normal quiescent state, whereby they increase synthesis of procollagen type I messenger RNA (mRNA) and protein, 1,2 and increase cellular proliferation, migration, and contractility. 3,4 Excess ECM accumulation results in scarring within the tissue. Our understanding of ECM degradation during hepatic fibrosis is still very limited. ECM degradation is mediated by matrix metalloproteinases (MMPs), a family of zinc-dependent enzymes grouped into collagenases, gelatinases, stromelysins, and membrane-type MMPs, 5 based upon their substrates. Interstitial collagenases (MMP-1 and MMP-13 in humans,

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“…It is also important to note that in order to obtain similar information using conventional techniques it would have been necessary to use substantially more animals than used in this study. To establish the time course of liver regeneration previous studies (7,8,12,14) have used a large number of animals, sacri ced groups of animals at various time points, and weighed the dissected livers. Results have usually been corrected for animal weight on the assumption that liver weight is directly proportional to body weight.…”

Section: Discussionmentioning

confidence: 99%

Longitudinal Magnetic Resonance Imaging Quantitation of Rat Liver Regeneration After Partial Hepatectomy

et al. 2002

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This report demonstrates the advantage s of using a noninvasive soft tissue imaging technique-magnetic resonance imaging (MRI)-to monitor liver regeneration after 70% partial hepatectomy in the rat in a longitudinal manner. Six animals were scanned prior to and on 6 subsequen t occasions up to 9 days after surgical removal of the median and left lateral lobes. Within the observed time frame liver volumes were restored to approximately 88% of presurgery values. The rate of regeneration was maximal at 1.5 days, which coincided with the maximum increase of Mitotic Index-a measure of cell proliferation, determined in a subsequen t study. Pre-and postpartial hepatectomy measurements remove two potentially confoundin g unknowns -the presurgery liver volume, and the amount of liver actually excised. 3D reconstruction s of the liver effectively illustrate the morphologica l changes associated with the procedure, and the regrowth of liver tissue.

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Phenobarbital in Comparison with Carbon Tetrachloride and Phenobarbital-Induced Cirrhosis in Rat Liver Regeneration

Cited by 11 publications

References 22 publications

Dimethylnitrosamine (DMN) exposed rats: Vernonia amygdalina pre-treatment enhances immunity, hepatic and renal function

Dimethylnitrosamine (DMN) exposed rats: Vernonia amygdalina pre-treatment enhances immunity, hepatic and renal function

Antifibrotic effects of a tissue inhibitor of metalloproteinase-1 antibody on established liver fibrosis in rats

Longitudinal Magnetic Resonance Imaging Quantitation of Rat Liver Regeneration After Partial Hepatectomy

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