Phenobarbital-Induced Pemphigus vulgaris

Dourmishev, A. L.; Rahman, Mohamed Abdel

doi:10.1159/000249263

Cited by 25 publications

(5 citation statements)

References 7 publications

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“…Finally, an increased frequency of HLA-B15 in these patients has been reported, suggesting that in such cases D-penicillamine unmasks a genetic predisposition [13]. Other [73], pemphigus-inducing drugs are piroxicam [69], penicillin [70], captopril [71,72], rifampicin, thiopronine [74], a-mercapto-propionyl-glycine [75], phenytoin and phenobarbitone [76]. D-Penicillamine-induced pemphigus may occur in 3-10% of patients [13,71].…”

Section: Drug-induced Pempbigusmentioning

confidence: 99%

Cutaneous drug reactions

Sehgal

Jain

Bhattacharya

1993

Acad Dermatol Venereol

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Section: Drug-induced Pempbigusmentioning

confidence: 99%

Cutaneous drug reactions

Sehgal

Jain

Bhattacharya

1993

Acad Dermatol Venereol

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“…Pemphigus‐like syndrome has been reported to arise in individuals after exposure to a variety of drugs. Drug‐induced pemphigus is most commonly associated with thiol drugs such as penicillamine and captopril; 5–10 however, pemphigus caused by nonthiol drugs has also been reported 11–15 . The majority of patients with drug‐induced pemphigus have circulating autoantibodies to Dsgs 1 and/or 3 and autoantibody deposition on the cell surface of epithelial cells 16,17 …”

Section: Introductionmentioning

confidence: 99%

Increased antibody levels to desmogleins 1 and 3 after administration of carbamazepine

Yoshimura¹,

Seishima

Nakashima³

et al. 2001

Clinical and Experimental Dermatology

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Desmoglein (Dsg) 1 and Dsg3 are recognized as the autoantigens in pemphigus foliaceus and pemphigus vulgaris. Pemphigus-like syndromes have been reported to occur in individuals after exposure to a variety of drugs, but pemphigus caused by carbamazepine is not common. We found that anti-Dsg1 and anti-Dsg3 antibody titres were increased in three individuals administered carbamazepine. Antibody titres against Dsgs 1 and 3 were measured by enzyme-linked immunosorbent assay (ELISA). Of 42 serum samples (25 patients administered carbamazepine, eight patients administered valproic acid and nine healthy volunteers) tested by ELISA, three patients administered carbamazepine showed positive reactivity against both Dsg1 and Dsg3. The patient with the highest titre against Dsg1 and Dsg3 (the index values of anti-Dsg1 and anti-Dsg3 were 79.3 and 86.4, respectively) was a 23-year-old woman (Case 1). The other two patients with positive reactivity were a 5-year-old boy (Case 2) and a 65-year-old man (Case 3). In addition, indirect immunofluorescence study showed intercellular antibodies to the cell surface of the whole epidermis with a titre of 1 : 64 in Case 1 and 1 : 2 in Cases 2 and 3. However, no skin or mucosal involvement was found in any of these cases. There was no difference in the serum concentrations of carbamazepine between the three positive cases and the 22 negative cases of carbamazepine administration. From these facts, the lack of skin diseases may be explained by relatively low values of anti-Dsg 1 and 3 antibodies in Cases 2 and 3. However, it cannot be excluded that undefined exogenous and/or endogenous factors are involved in an outbreak of pemphigus. Furthermore, these findings might be helpful for preventing susceptible individuals from exposure to the suspect drugs.

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“…piroxicam) [5.,6]. nifedipine) [7][8][9], but to the best of our knowledge no report has documented pemphigus triggered by the antirheumatic agent diclofenac. rifampicin.…”

Section: Introductionmentioning

confidence: 99%

Pemphigus triggered by diclofenac

Pellicano

Iannantuono

Ciommo

et al. 1996

Acad Dermatol Venereol

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We report a case of pemphigus vulgaris which first appeared in a young Italian male during treatment with diclofenac. The initial lesions persisted for 5 months after the drtig was discontintjcd and later worsened when the patient was treated wilh piroxicam. HLA typing revealed the presence of 3 antigen.s which have been shown to be associated with pemphigus (B55, DR6. DQl). This appears to be the first report of petiiphigus vulgaris triggered by diclofenac.

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Phenobarbital-Induced Pemphigus vulgaris

Cited by 25 publications

References 7 publications

Cutaneous drug reactions

Cutaneous drug reactions

Increased antibody levels to desmogleins 1 and 3 after administration of carbamazepine

Pemphigus triggered by diclofenac

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