Phenobarbitone in neonatal jaundice

Sinniah, Davendralingam; Tay, Lay; Dugdale, A. E.

doi:10.1136/adc.46.249.712

Cited by 11 publications

(3 citation statements)

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“…The use of phenobarbitone in the treatment of neonatal jaundice [27,33] and of the unconjugated hyperbilirubinaemia in the type II CriglerNajjar syndrome [2] and in Gilbert's syndrome [5,14] is also well known, although the mechanisms involved are not clearly understood. Since pheno barbitone is a powerful enzyme-inducing agent in animals [9], the implication in these clinical studies has been that bilirubin conjugation is enhanced as a result of induction of UDP-glucuronyl transferase (UDP-GT).…”

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Effect of Phenobarbitone on Bile Flow and Bilirubin Metabolism in Man and the Rat

et al. 1973

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Phenobarbitone in doses causing significant increase in bile flow had no effect on plasma bilirubin levels in the rat, nor on biliary excretion of endogenous bilirubin. In patients with Gilbert’s syndrome small doses of phenobarbitone lowered bilirubin levels without any accompanying change in BSP Tm. In these patients and in normal subjects the fall in plasma bilirubin after enzyme-inducing drugs was correlated with changes in the activity of hepatic enzymes. These studies suggest that species variations in response to the effects of phenobarbitone on bilirubin metabolism may be important

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Effect of Phenobarbitone on Bile Flow and Bilirubin Metabolism in Man and the Rat

et al. 1973

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“…Several studies on the effect of phenobarbital on the hyperbilirubinemia of non-hemolytic disease of newborn infants have been conducted, which have shown that phenobarbital decreases the rate of blood exchange transfusion 9,11–13,16–21 ; on the other hand, some studies have reported that phenobarbital has no effect on the TSB level in newborns with nonhemolytic disease and thus has no effect on the rate of blood exchange transfusion. 22,23…”

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Phenobarbital and Phototherapy Combination Enhances Decline of Total Serum Bilirubin and May Decrease the Need for Blood Exchange Transfusion in Newborns with Isoimmune Hemolytic Disease

Kaabneh

Salama

Shakkoury

et al. 2015

Clin Med Insights Pediatr

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OBJECTIVEThe objective of this study was to evaluate the effect of phenobarbital and phototherapy combination on the total serum bilirubin of the newborn infants with isoimmune hemolytic disease (IHD) and its impact on blood exchange transfusion rates.PATIENTS AND METHODThis single-blinded, prospective, randomized, controlled trial was conducted between March 2013 and December 2014 at the pediatric ward of two Military Hospitals in Jordan. A total of 200 full-term neonates with IHD were divided randomly into two groups: (1) the phenobarbital plus phototherapy group (n = 103), and (2) the phototherapy-only group (n = 97). Infants in group 1 received an oral dose of 2.5 mg/kg phenobarbital every 12 hours for 3 days in addition to phototherapy. The total serum bilirubin was observed.RESULTSOf the total 200 included newborn infants, 186 infants completed the study: 97 infants were included in group 1 and 89 infants in group 2. The difference between the mean total serum bilirubin levels at 24, 48, and 72 hours after starting the trial was clinically and statistically significant at P < 0.05. The differences between the two groups were also statistically significant at P < 0.05. Of the total 186 who completed the study, only 22 underwent blood exchange transfusion [7 from group 1, and 15 from group 2 (P = 0.0478)].CONCLUSIONIn a limited-resources setting, phenobarbital in combination with phototherapy may be helpful to newborn infants with IHD, as it results in a faster decline in total serum bilirubin, thus decreasing the need for blood exchange transfusion than phototherapy alone.

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“…55 59 68 70 74 80 86 87 . 'Αρνητικά αποτελέσματα αναφέρουν έτεροι έρευνηταί25 46 63 επί χορηγήσεως τής φαινοβαρβιτάλης μετά τήν γέννησιν, βέβαιον δμως είναι δτι ή πτώσις τής χολερυθρίνης παρατηρείται μετά τήν 3ην τουλάχιστον ήμέραν από τής χορηγήσεως του φαρμάκου5 23 49 70 80 .…”

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Επιδρασις Της Γλυκαγονης Επι Των Τιμων Της Χολερυθρινης Του Αιματος Νεογνων Μετα Νεογνικου Ικτερου

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Σελίς Βιογραφικό ν σημείωμα 13 Πρόλογος ΓΕΝΙΚΟΝ ΜΕΡΟΣ 17 Ι. Μεταβολισμός της χολερυθρίνης Α. Σχηματισμός της χολερυθρίνης Β. Πρόσληψις της χολερυθρίνης ύπό του ήπατικοΰ κυττάρου 19 Γ.Άπέκκρισις της χολερυθρίνης διά της χολής 19 Δ. Μεταβολισμός της χολερυθρίνης εις τά νεογνά 19 II. Φαρμακευτικοί παράγοντες προκαλούντες έπαγωγήν της χολεριθρύνης 20 ΕΙΔΙΚΟΝ ΜΕΡΟΣ ΗΜΕΤΕΡΑ ΜΕΛΕΤΗ Α.Ύλικόν -'Ασθενείς καί Μέθοδοι Β. 'Αποτελέσματα Γ. Συζήτησις Δ. Περίληψις Ε. SUMMARY ΣΤ. Βιβλιογραφία ΒΙΟΓΡΑΦΙΚΟ ΣΗΜΕΙΩΜΑ ΜΙΧΑΗΛ Ι. ΔΑΒΑΚΗ

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Phenobarbitone in neonatal jaundice

Cited by 11 publications

References 14 publications

Effect of Phenobarbitone on Bile Flow and Bilirubin Metabolism in Man and the Rat

Effect of Phenobarbitone on Bile Flow and Bilirubin Metabolism in Man and the Rat

Phenobarbital and Phototherapy Combination Enhances Decline of Total Serum Bilirubin and May Decrease the Need for Blood Exchange Transfusion in Newborns with Isoimmune Hemolytic Disease

Επιδρασις Της Γλυκαγονης Επι Των Τιμων Της Χολερυθρινης Του Αιματος Νεογνων Μετα Νεογνικου Ικτερου

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