Phenol solubilization in aqueous Pluronic® solutions: Investigating the micellar growth and interaction as a function of Pluronic® composition

Ganguly, R.; Kuperkar, Ketan; Parekh, Paresh; Aswal, Vinod K.; Bahadur, Pratap

doi:10.1016/j.jcis.2012.04.034

Cited by 35 publications

(24 citation statements)

References 58 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Similar kinds of results were obtained by several other researchers. [61][62][63][64][65] The very low decrease in CPT of P123 in the case of PLL was due to the hydrophilic nature of the LTG drug.…”

Section: Characterization Of Drug-loaded Pluronics P123 Nanomicellesmentioning

confidence: 98%

Enhanced Solubility and Oral Bioavailability of Hydrophobic Drugs Using Pluronic Nanomicelles: An In‐Vitro Evaluation

et al. 2021

View full text Add to dashboard Cite

This communication is dedicated to Late Yogesh Chamkure for his forever memories in Dr Rakesh K. Sharma's research laboratory.Poor drug solubility and oral bioavailability is a significant challenge with many effective drug candidates. Pluronic micelles are effective solutions for improved solubility, stability, and delivery of the hydrophobic drug to the right area, at the right time, and in the right amount. Solubilization of three drugs, namely curcumin (CUR), quercetin (QCN), and lamotrigine (LTG), were explored using Pluronics with varying molecular characteristics. All the drugs showed better solubility in Pluronic solutions. The tendency of augmentation in solubility was QCN > CUR > LTG. Results showed better solubilization of drugs in Pluronics which form micelles and have low CMTs. With an objective to enhance the oral bioavailability of drugs, the drug-loaded Pluronic P123 nanomicelles (PLC for CUR, PLQ for QCN, and PLL for LTG) have been prepared and characterized using UV-VIS, DLS, SANS, CPT, and TEM measurements. The drug-loaded P123 nanomicelles having particle sizes range from 18 to 22.5 nm and spherical in shapes. In the in-vitro release study, CUR and QCN showed slow release,while LTG exhibited a faster release profile. The PLC and PLQ assessed their anti-oxidant potential had confirmed the oxidation resistance more significantly than the free drug. Considering the pharma uses of CUR, QCN, and LTG drugs and observing the application of Pluronics in drug delivery systems, the present work facilitates insight into the possible formulations of these drugs.

show abstract

Section: Characterization Of Drug-loaded Pluronics P123 Nanomicellesmentioning

confidence: 98%

Enhanced Solubility and Oral Bioavailability of Hydrophobic Drugs Using Pluronic Nanomicelles: An In‐Vitro Evaluation

et al. 2021

View full text Add to dashboard Cite

show abstract

“…This result is completely opposite to the behavior reported for HPG-C 18 -PEG copolymers where solubilization of pyrene molecules induces a transition from multimolecular aggregates to unimolecular micelles [34]. On the other hand, for polymer micelles formed by linear block copolymers it has been found that solubilization of phenols and other additives induce micellar growth [38][39][40]. …”

Section: Characterization Of Polymer Aggregatesmentioning

confidence: 65%

Solubilization of phenols by multimolecular aggregates formed by low molecular weight hyperbranched polyglycidol

Olea

Acevedo

Ossandon

et al. 2017

Colloids and Surfaces A: Physicochemical and Engineering Aspect

View full text Add to dashboard Cite

“…For the determination of micelle size in the presence of LTG incorporated Pluronic Ò F127 micelles, DLS was used [40]. In drug delivery, the size of the drug carrier is important as it plays a key role in drug accumulation and penetration in cells, i.e., the micelle size should be large enough for circulation as well as small enough for penetration [41].…”

Section: Resultsmentioning

confidence: 99%

Incorporation of Lamotrigine Drug in the PEO–PPO–PEO Triblock Copolymer (Pluronic F127) Micelles: Effect of Hydrophilic Polymers

Shaikh

Ray²,

Aswal³

et al. 2017

J Surfact & Detergents

View full text Add to dashboard Cite

The hydrophobic drug Lamotrigine (LTG) shows low bioavailability after oral administration. Work has been performed to improve the aqueous solubility of LTG using the micelles of amphiphilic block copolymers. Polyethylene oxide-polypropylene oxide-polyethylene oxide triblock copolymers (PEO-PPO-PEO), known as Pluronic Ò , have been the subject of current interest due to the versatile structural possibilities of varying PEO/PPO ratios. Incorporation of LTG in the aqueous micellar solutions of Pluronic Ò F127 was investigated using UVvisible spectroscopy. The shapes and size of the micelles with and without LTG have been ascertained using dynamic light scattering and small angle neutron scattering experiments. Results show increase in the Pluronic Ò micellar size with hard sphere radius with the incorporation of LTG. The effect of hydrophilic polymers (PEG1500 and F68) on the LTG-incorporated Pluronic Ò F127 micelles was also studied and found inefficient for enhancement of the solubility of LTG. Solid forms of LTG-incorporated Pluronic Ò F127 micelles with and without hydrophilic polymers, coded as LPMs, were successfully prepared through the thin-film hydration method. Fourier transform infrared spectroscopy, X-ray diffraction spectroscopy and thermogravimetric analysis have been used to ensure the compatibility of the LTG with Pluronic Ò F127 micelles in prepared LPMs. All the LPMs showed good incorporation efficiency, loading capacity and the sustained release profile of LTG. Results showed no specific improvement with the addition of hydrophilic polymers in the studied concentration range.

show abstract

Phenol solubilization in aqueous Pluronic® solutions: Investigating the micellar growth and interaction as a function of Pluronic® composition

Cited by 35 publications

References 58 publications

Enhanced Solubility and Oral Bioavailability of Hydrophobic Drugs Using Pluronic Nanomicelles: An In‐Vitro Evaluation

Enhanced Solubility and Oral Bioavailability of Hydrophobic Drugs Using Pluronic Nanomicelles: An In‐Vitro Evaluation

Solubilization of phenols by multimolecular aggregates formed by low molecular weight hyperbranched polyglycidol

Incorporation of Lamotrigine Drug in the PEO–PPO–PEO Triblock Copolymer (Pluronic F127) Micelles: Effect of Hydrophilic Polymers

Contact Info

Product

Resources

About