Phenolic acid metabolites as biomarkers for tea- and coffee-derived polyphenol exposure in human subjects

Hodgson, Jonathan M.; Chan, Shin Yee; Puddey, Ian B.; Devine, Amanda; Wattanapenpaiboon, Naiyana; Wahlqvist, Mark L.; Lukito, Widjaja; Burke, Valerie; Ward, Natalie C.; Prince, Richard; Croft, Kevin D.

doi:10.1079/bjn20031046

Cited by 65 publications

(40 citation statements)

References 29 publications

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“…Few authors have examined so far correlations between polyphenol intake and polyphenol excretion in urine in free-living populations (Maskarinec et al, 1998;Lampe et al, 1999;Hodgson et al, 2004). We recently showed that urinary polyphenols correlate with intake of various polyphenol-rich food and beverages (Mennen et al, 2006).…”

Section: Discussionmentioning

confidence: 96%

Urinary excretion of 13 dietary flavonoids and phenolic acids in free-living healthy subjects – variability and possible use as biomarkers of polyphenol intake

et al. 2007

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Objective: Estimation of dietary intake of polyphenols is difficult, due to limited availability of food composition data and bias inherent to dietary assessment methods. The aim of the present study was to evaluate whether we could detect polyphenols and their metabolites in a spot urine sample in a free-living human population and whether it was related to those observed in 24-h urine samples, for potential use as a biomarkers of polyphenol intake. Subjects: Four 24-h urine samples and two spot urine samples were collected from 154 participants of the SU.VI.MAX cohort (a randomized primary-prevention trial evaluating the effect of daily antioxidant supplementation on chronic diseases) in two separate studies over, respectively, a 7-and 2-day periods. Thirteen polyphenols and metabolites (chlorogenic acid (CGA), caffeic acid (CA), m-coumaric acid (mCOU), gallic acid (GA), 4-O-methylgallic acid (MeGA), quercetin (Q), isorhamnetin (MeQ), kaempferol (K), hesperetin (HESP), naringenin (NAR), phloretin (PHLOR), enterolactone (ENL) and enterodiol (END) were measured using HPLC-ESI-MS-MS. Results: Correlations between the urinary excretion levels were observed. The most significant were explained by metabolic filiations (CGA/CA, CA/mCOU, GA/MeGA, Q/MeQ, NAR/PHLOR, ENL/END) or co-occurrence in a same food source (NAR/ HESP). Concentrations in spot samples correlated with those in 24-h urine sample (Po0.02, except for CA and for MeQ). Intraindividual variations were smaller than inter-individual variations for all polyphenols (Po0.01) except for MeGA and for PHLOR. Conclusion: These results show that these polyphenols and metabolites are useful biomarkers for polyphenol intake.

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Section: Discussionmentioning

confidence: 96%

Urinary excretion of 13 dietary flavonoids and phenolic acids in free-living healthy subjects – variability and possible use as biomarkers of polyphenol intake

et al. 2007

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“…However, the NPV was 60% because of a high percentage of false negatives among intermittent drinkers. Thus, urinary concentrations of resveratrol metabolites are particularly useful as biomarkers of wine intake for moderate and regular drinkers, just as other phenolic compounds have been shown to be useful biomarkers for the intake of fruits, vegetables, tea, or coffee (14,23 ). We selected resveratrol as a marker of wine intake because it is a characteristic polyphenol of grape and wine products.…”

Section: Discussionmentioning

confidence: 99%

“…Resveratrol metabolites could be the best nutritional biomarkers for wine consumption because trans-resveratrol-3-O-glucuronide has been reported to be the main resveratrol metabolite in human blood (10 ), urine (11 ), LDL (12 ), and target organs (13 ). Other phenolic metabolites previously used as biomarkers of food consumption include 4Ј-O-methylgallic acid (the main gallic acid metabolite) for tea (14 ), isoferulic acid for coffee (14 ), and isoflavonoids for soy (15 ).…”

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confidence: 99%

Diagnostic Performance of Urinary Resveratrol Metabolites as a Biomarker of Moderate Wine Consumption

et al. 2006

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Background: Nutritional biomarkers may be better measures of dietary exposure than self-reported dietary data. We evaluated resveratrol metabolites, potential biomarkers of wine consumption, in humans after moderate consumption of sparkling, white, or red wines. Methods: We performed 2 randomized, crossover trials and a cohort study. In the first study, 10 healthy men consumed 30 g of ethanol/day as sparkling wine or gin for 28 days. In the second trial, 10 healthy women consumed 20 g of ethanol/day as white or red wine for 28 days. We also evaluated 52 participants in a study on the effects of a Mediterranean diet on primary prevention of cardiovascular disease (the PREDIMED Study). We used liquid chromatography-tandem mass spectrometry to analyze urinary total resveratrol metabolites (TRMs) and predictive values and ROC curve analyses to assess the diagnostic accuracy. Results: We observed significant increases in TRMs [72.4 (95% confidence interval, 48.5-96.2; P ‫؍‬ 0.005), 211.5 (166.6 -256.3; P ‫؍‬ 0.005), and 560.5 nmol/g creatinine (244.9 -876.1; P ‫؍‬ 0.005)] after consumption of sparkling, white, or red wine, respectively, but no changes after the washout or gin periods. In the cohort

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“…In the absence of disease, creatinine concentrations in serum and urine are usually very stable and can be used to estimate the urinary excretion of substances with only spot urine samples (21)(22)(23)(24). Therefore, in this study, we expressed total urinary polyphenol excretion per grams of creatinine excreted in the urine rather than per milliliters of urine.…”

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confidence: 99%

Total Polyphenol Intake Estimated by a Modified Folin–Ciocalteu Assay of Urine

et al. 2006

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adrenocorticotropin test in the assessment of hypothalamic-pituitary-adrenal function. Eur J Endocrinol 1998;139:575-9 Background: Plant polyphenols have been studied largely because of the possibility that they might underlie the protective effects afforded by fruit and vegetable intake against cancer and other chronic diseases. Measurement of polyphenol content excreted in urine as an indicator of polyphenol consumption may offer a routine screening method that could be used for these pathologies. Methods: Thirty-six healthy volunteers each received 2 interventions, one with a polyphenol-rich food (cocoa beverage) and one with a polyphenol-free food (milk) as a control, in a randomized cross-over design with 1-week intervals. The total polyphenol content excreted in urine during the 6 h after consumption of the test meals was measured by a modified Folin-Ciocalteu assay after sample cleanup by solid-phase extraction.

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Phenolic acid metabolites as biomarkers for tea- and coffee-derived polyphenol exposure in human subjects

Cited by 65 publications

References 29 publications

Urinary excretion of 13 dietary flavonoids and phenolic acids in free-living healthy subjects – variability and possible use as biomarkers of polyphenol intake

Urinary excretion of 13 dietary flavonoids and phenolic acids in free-living healthy subjects – variability and possible use as biomarkers of polyphenol intake

Diagnostic Performance of Urinary Resveratrol Metabolites as a Biomarker of Moderate Wine Consumption

Total Polyphenol Intake Estimated by a Modified Folin–Ciocalteu Assay of Urine

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