Phenolic acids inhibit chloroplast mutagenesis in Euglena gracilis

Euglenoid flagellates: A multifaceted biotechnology platform

“…Subsequent studies documented that natural dietary inhibitors of mutagenesis such as lignin, suberin, flavonoids, plant phenolics, mannans and mannan conjugates, glucan derivatives (Belicová et al, 2001;Ebringer et al, 1996;Križková et al, 2000Križková et al, , 2001Križková et al, , 2003Križková et al, , 2006Nagy et al, 2009) as well as novel derivatives of chitosans (Kogan et al, 2004) significantly reduced bleaching in Euglena induced by fluoroquinolone antibacterial drug ofloxacin used as a very effective model chloroplast eliminator. Thus bleaching in E. gracilis can be widely applied for screening of naturally occurring or synthetic antimutagens.…”

Genotoxic effect of gallic and ellagic acids in somatic and germ cells of Drosophila melanogaster

“…In addition to known activity, phenolic acids have been tested in order to assess genotoxic and potential antigenotoxic activities. Phenolic acids, as ferulic, caffeic and gentisic, are known to exhibit protective effect against the genotoxicity of acridin orange and ofloxacin in Salmonella typhimurium and Euglena gracilis (KRIŽKOVÁ et al, 2000;BELICOVÁ et al, 2001;BIROŠOVÁ et al, 2005). YAMADA and TOMITA (1996) described that caffeic and chlorogenic acid possesses inhibitory effect on the mutagenicity of 3-amino-l,4-dimethyl-5Hpyrido [4,3-b]indole (Trp-P-1), and 2-aminodipyrido[l,2-a:3',2'-d]imidazole (Glu-P-2).…”

Comparative study of the antimutagenic properties of vitamins C and E against mutation induced by norfloxacin

“…Fluoroquinolone-induced oxidative damage may be inhibited by antioxidant compounds. In several short genotoxic test systems, Krizkova et al [ 4 ]. have inhibited ofloxacin mutagenesis of Euglena gracilis , by using phenolic compounds like caffeic acid and ferulic acid.…”

“…have inhibited ofloxacin mutagenesis of Euglena gracilis , by using phenolic compounds like caffeic acid and ferulic acid. The oxidative DNA damage in S. thyphimurium TA1O2 induced by norfloxacin is inhibited by β-carotene metabolites or naturally occurring extracts from plants such as Roheo discolor [ 4 , 5 ]. These data provide evidence that norfloxacin is an ROS-generating drug.…”