Phenolic acids of Ephedra equisetina

Chumbalov, T. K.; Chekmeneva, L. N.; Polyakov, V. V.

doi:10.1007/bf00563959

Cited by 8 publications

(3 citation statements)

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“…The latter compound was also reported from E. lomatolepis Schrenk [ 80 ] and compound 74 from E. equisetina Bunge [ 77 ]. Thereafter, Hussein et al reported the isolation and structure elucidation of 2″,2″-di- O -β-glucopyranosylvicenin 2 ( 67 ) and herbacetin 3- O -α-rhamnopyranoside 8- O -β-gluco-pyranoside ( 65 ).…”

Section: Chemistrymentioning

confidence: 72%

“…For the Ephedra genus, flavonoids and phenolic compounds are the other most diverse class of specialized metabolites derived from its species ( Figure 2 ). Chumbalov et al had previously identified benzoic acid ( 27 ), p -hydroxybenzoic acid ( 28 ), vanillic acid ( 29 ), protocatechuic acid ( 30 ), trans -cinnamic acid ( 32 ) and p -coumaric acid ( 33 ) from E. equisetina Bunge [ 77 ]. The phytochemical study of E. lomatolepis Schrenk lead to the isolation of proanthocyanidins described as dimers A 1 -A 3 based on catechin ( 45 , [ 78 ]) and (−)-epicatechin ( 46 , [ 79 ]) or dimers based on afzelechin ( 54 , [ 70 ]).…”

Section: Chemistrymentioning

confidence: 99%

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A Review of the Ephedra genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties

et al. 2020

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Ephedra is one of the largest genera of the Ephedraceae family, which is distributed in arid and semiarid regions of the world. In the traditional medicine from several countries some species from the genus are commonly used to treat asthma, cold, flu, chills, fever, headache, nasal congestion, and cough. The chemical constituents of Ephedra species have been of research interest for decades due to their contents of ephedrine-type alkaloids and its pharmacological properties. Other chemical constituents such as phenolic and amino acid derivatives also have resulted attractive and have provided evidence-based supporting of the ethnomedical uses of the Ephedra species. In recent years, research has been expanded to explore the endophytic fungal diversity associated to Ephedra species, as well as, the chemical constituents derived from these fungi and their pharmacological bioprospecting. Two additional aspects that illustrate the chemical diversity of Ephedra genus are the chemotaxonomy approaches and the use of ephedrine-type alkaloids as building blocks in organic synthesis. American Ephedra species, especially those that exist in Mexico, are considered to lack ephedrine type alkaloids. In this sense, the phytochemical study of Mexican Ephedra species is a promising area of research to corroborate their ephedrine-type alkaloids content and, in turn, discover new chemical compounds with potential biological activity. Therefore, the present review represents a key compilation of all the relevant information for the Ephedra genus, in particular the American species, the species distribution, their ecological interactions, its ethnobotany, its phytochemistry and their pharmacological activities and toxicities, in order to promote clear directions for future research.

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Section: Chemistrymentioning

confidence: 72%

Section: Chemistrymentioning

confidence: 99%

A Review of the Ephedra genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties

et al. 2020

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“…The phenolic acids 1, 3, 5, 7, 10 and 14 were identified respectively as gallic acid, protocatechuic acid, p-hydroxybenzoic acid, p-hydroxybenzaldehyde, coumaric acid and ferulic acid by comparison with commercial standards. Indeed, coumaric acid [17,18] , p-hydroxybenzoic and protocatechuic acids [17,19] were previously described in E. alata, E. aphylla and E. equisetina. Peak 2 showed UV maxima absorption at ≈259 nm and 294 nm and a precursor ion at m/z 315 [M-H] − in the negative ionization mode.…”

Section: Table 4: Anti-inflammatory Properties α-Amylase and Pancreat...mentioning

confidence: 99%

Phenolic Composition, In Vitro Alpha-Amylase and Pancreatic Lipase Inhibitory Effects, Anti-Inflammatory and Antioxidant Activities of Ephedra altissima

Bouafia¹,

Hamdi²,

Mouffouk³

et al. 2022

IJPS

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Bouafia et al.: Biological Activities and Phenols from Ephedra altissimaThis study aimed to investigate the phytochemical composition, alpha-amylase and pancreatic lipase inhibitory activities and anti-inflammatory and antioxidant properties of the crude extracts (petroleum ether, ethyl acetate and n-butanol) obtained from the aerial parts of Ephedra altissima. The characterization of the phenolic compounds in crude extracts was performed by high performance liquid chromatographyphotodiode array detection-electrospray ionization-mass spectrometry and the in vitro alpha-amylase and pancreatic lipase inhibitory activities were evaluated using starch and p-nitrophenyl butyrate as substrates, respectively. Furthermore, the anti-inflammatory activity was carried out by bovine serum albumin denaturation method and the antioxidant capacity was assessed using five different assays. Flavonol and flavone glycoside derivatives and phenolic acids, especially isovitexin-2-O-rhamnoside and vicenin II were the major compounds in the n-butanol extract. Otherwise, the ethyl acetate extract presented kaempferol-3-O-rhamnoside, quercetin-3-O-rhamnoside and protocatechuic acid as its main compounds. The n-butanol extract revealed the highest content of total phenolic compounds. The results for antioxidant activity showed that ethyl acetate extract possesses the strongest activity in all the tested methods. Moreover, the ethyl acetate extract displayed the best anti-inflammatory, alpha-amylase and pancreatic lipase inhibitory activities with half-maximal inhibitory concentration values of 126.43, 9.02 and 289.11 µg/ml, respectively. These results give obvious support to the use of Ephedra altissima in traditional medicine for the treatment of diabetic diseases. Also, the moderate alpha-amylase inhibitory activity of Ephedra altissima extracts make advantage of its therapeutic applications compared to the synthetic drugs, since their strong alphaamylase inhibitory effects are associated to many digestive adverse effects including the abnormal bacterial fermentation in the colon.

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Quality marker identification based on standard decoction of differently processed materials of Ephedrae Herba

Dai

Tong

et al. 2019

Journal of Ethnopharmacology

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Phenolic acids of Ephedra equisetina

Cited by 8 publications

References 0 publications

A Review of the Ephedra genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties

A Review of the Ephedra genus: Distribution, Ecology, Ethnobotany, Phytochemistry and Pharmacological Properties

Phenolic Composition, In Vitro Alpha-Amylase and Pancreatic Lipase Inhibitory Effects, Anti-Inflammatory and Antioxidant Activities of Ephedra altissima

Quality marker identification based on standard decoction of differently processed materials of Ephedrae Herba

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