Phenolic alkaloids as a new class of antioxidants in <i>Portulaca oleracea</i>

Yang, Zijuan; Liu, Cejia; Xiang, Lan; Zheng, Yi-Nan

doi:10.1002/ptr.2742

Cited by 149 publications

(86 citation statements)

References 9 publications

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“…Portulene; a diterpene [192]. Phenolic alkaloids; oleracein A, oleracein B, and oleracein E [193]. Betacyanins [194] Moderate antidiabetic activity via potent antioxidant potential in STZ-diabetic rats [195] 22 Rosaceae Crataegus aronia L. Bosc.…”

mentioning

confidence: 99%

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

2011

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mentioning

confidence: 99%

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

2011

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“…Oleracein E (the antipode of trolline) has been reported to exhibit potent DPPH radical scavenging activity (Yang et al, 2009). Other cytotoxic compounds characterized from M. jalapa, notably the cytotoxic rotenoids mirabijalones and boeravinones have been shown to have growth inhibition effects against several cell lines (Wang et al, 2002;Xu et al, 2010).…”

Section: Discussionmentioning

confidence: 99%

In silico physico-chemical evaluation, anti-inflammatory and mcf-7 breast cancer cell line growth inhibition effects of trolline isolated from Mirabilis jalapa

Sadiq¹,

Inuwa²,

Rehman³

et al. 2016

J. Med. Plants Res.

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The in silico simulations and predictions approach in evaluation of pharmacokinetic properties of new chemical entities (NCEs) is fast becoming an acceptable trend in natural products research and drug discovery. This paper focuses on the properties of trolline with respect to its anti-inflammatory and MCF-7 breast cancer cell line growth inhibition effects and an attempt to predict physico-chemical druglike properties in silico. The compound was isolated for the first time from aerial parts of Mirabilis jalapa and the structure was elucidated by 1D and 2D NMR, FTIR and mass spectroscopic analyses. The compound was screened for anti-inflammatory and anti-MCF-7 cell lines proliferation using chemoluminiscence oxidative burst and MTT assays respectively. Predictions on physico-chemical properties central to oral route drug administration were done using commercial software Admet predictor. Results show anti-inflammatory effects at IC 50 concentration of 53.8 µg/ml and 48% mortality of breast cancer cell lines at 50 µM concentration. Predictions suggest moderate solubility of 1.72 to 2.92 mg/ml across pH range of 1.6 to 6.8 in simulated solvent systems and effective jejunal permeability of 5.61 x 10 -4 cm/s. The compound was also predicted to be 60% unbound to plasma proteins and an LD 50 of 950 mg/kg in rats. The compound, trolline had clinically important bioactive effects, probably possess promising drug-like properties suitable for further high throughput screening.

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“…However, few molecular mechanisms of action are known. Phenolic alkaloids such as three oleraceins was reported by (Yang et al, 2009) as a new class of antioxidants in purslane, showing a higher DPPH radical scavenging activity than ascorbic acid and alpha-tocopherol. Alpha-tocopherol, ascorbic acid, beta-carotene and glutathione in leaves of purslane exhibited higher amount than did in spinach (Simopoulos et al, 1992).…”

Section: Other Bioactives In Purslanementioning

confidence: 99%

Redefining Unusable Weeds to Beneficial Plants: Purslane as a Powerful Source of Omega-3 for the Future

Agil¹,

Gilbert²,

Tavakoli³

et al. 2015

JFR

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With global consumer demand shifting towards the consumption of healthier foods, it is crucial to discover new sources of edible plants with high nutritional value and low cost. Unique weeds such as purslane have the potential to be used as an untapped source of unconventional food with diverse nutrients and beneficial bioactive properties. Inflammation can cause oxidative stress related diseases including cardiovascular disorders, aging and cancer. One key nutrient of purslane is omega-3 with potential of inhibitory properties against inflammatory and estrogenic mediators. Purslane is known to be a rich source of α-linolenic acid, 18:3 ω-3, an essential fatty acid, carotenes, antioxidants and minerals. However, the precise mechanism of action of its individual components in disease prevention is unknown. This review provides a summary on the role of purslane bioactives, particularly omega-3 fatty acids as one of purslane's main constituents with potential of anti-inflammatory and anti-estrogenic properties. The discovery of new sources of plants rich in omega-3 fatty acids may be a useful strategy in utilizing natural alternative sources of foods that can enhance human health and wellbeing.

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Phenolic alkaloids as a new class of antioxidants in Portulaca oleracea

Cited by 149 publications

References 9 publications

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

Medicinal Plants from Jordan in the Treatment of Diabetes: Traditional Uses vs.In VitroandIn VivoEvaluations – Part 2

In silico physico-chemical evaluation, anti-inflammatory and mcf-7 breast cancer cell line growth inhibition effects of trolline isolated from Mirabilis jalapa

Redefining Unusable Weeds to Beneficial Plants: Purslane as a Powerful Source of Omega-3 for the Future

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