Phenolic and terpenoid compounds from Chione venosa (sw.) urban var. venosa (Bois Bandé)

Lendl, Angelika; Werner, Ingrid M.; Glasl, Sabine; Kletter, Christa; Mučaji, Pavel; Presser, Armin; Reznicek, Gottfried; Jurenitsch, J.; Taylor, David W.

doi:10.1016/j.phytochem.2005.07.002

Cited by 44 publications

(24 citation statements)

References 29 publications

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“…In order to identify the flavonoids, the NaOCH 3 , AlCl 3 /HCl, and NaOAc/H 3 BO 3 UV spectrum were also used (Mabry et al, 1970). All these data were in good agreement with the respective literature data (Ahmad et al, 1987;Ali et al, 2007;Lendl et al, 2005;Markham, 1982;Markham & Geiger, 1993;Mizushina et al, 2006;Wang et al, 2009). …”

supporting

confidence: 79%

Compounds fromSedum caeruleumwith antioxidant, anticholinesterase, and antibacterial activities

Bensouici

Kabouche

Karioti

et al. 2015

Pharmaceutical Biology

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Context: This is the first study on the phytochemistry, antioxidant, anticholinesterase, and antibacterial activities of Sedum caeruleum L. (Crassulaceae). Objective: The objective of this study is to isolate the secondary metabolites and determine the antioxidant, anticholinesterase, and antibacterial activities of S. caeruleum. Materials and methods: Six compounds (1-6) were isolated from the extracts of S. caeruleum and elucidated using UV, 1D-, 2D-NMR, and MS techniques. Antioxidant activity was investigated using DPPH , CUPRAC, and ferrous-ions chelating assays. Anticholinesterase activity was determined against acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) enzymes using the Ellman method. Antibacterial activity was performed according to disc diffusion and minimum inhibitory concentration (MIC) methods. Results: Isolated compounds were elucidated as ursolic acid (1), daucosterol (2), b-sitosterol-3-O-b-D-galactopyranoside (3), apigenin (4), apigetrin (5), and apiin (6). The butanol extract exhibited highest antioxidant activity in all tests (IC 50 value: 28.35 ± 1.22 mg/mL in DPPH assay, IC 50 value: 40.83 ± 2.24 mg/L in metal chelating activity, and IC 50 value: 23.52 ± 0.44 mg/L in CUPRAC), and the highest BChE inhibitory activity (IC 50 value: 36.89 ± 0.15 mg/L). Moreover, the chloroform extract mildly inhibited (MIC value: 80 mg/mL) the growth of all the tested bacterial strains. Discussion and conclusion: Ursolic acid (1), daucosterol (2), b-sitosterol-3-O-b-D-galactopyranoside (3), apigenin (4), apigetrin (5), and apiin (6) were isolated from Sedum caeruleum for the first time. In addition, a correlation was observed between antioxidant and anticholinesterase activities of bioactive ingredients of this plant.

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supporting

confidence: 79%

Compounds fromSedum caeruleumwith antioxidant, anticholinesterase, and antibacterial activities

Bensouici

Kabouche

Karioti

et al. 2015

Pharmaceutical Biology

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“…1). All the data were consistent with the literature (Khalil & Idler, 1980;Ahmad et al, 2003;Wanchai et al, 2003;Lendl et al, 2005).…”

Section: Resultssupporting

confidence: 91%

Phytochemical Study and Antiprotozoal Activity of Compounds Isolated fromThalia geniculata.

Lagnika

Attioua

Weniger

et al. 2008

Pharmaceutical Biology

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Thalia geniculata L. (Marantaceae) is an African medicinal plant traditionally used in Benin to treat malaria and other parasitic diseases. There is little ethnobotanical and almost no chemical information available for this species. The phytochemical analysis of the aerial parts of the plant led to the isolation of five compounds, identified as sitoindoside2), stigmasterol (3), β-sitosterol (4), and geranylfarnesol (5). The structural elucidation was achieved using spectrometric methods and by comparison with the literature. Biological activity was evaluated against Plasmodium falciparum, Trypanosoma rhodesiense, Trypanosoma cruzi, and Leishmania donovani. Geranylfarnesol (5) showed significant antiprotozoal activity against P. falciparum and L. donovani, with IC 50 values of 12.7 and 13.2 µM, respectively.

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“…Sitosterol-3-O-[b-D-glucopyranoside] (daucosterol) (3) was identified by comparison with literature data. 15) Compound 7 was identified as the dolabellane diterpene (1R,2R,3E,7E,11R,12S)-2-O-acetyl-16-O-(3-hydroxy-3-methylglutaryl)-dolabella-3,7-dien-2,16,18-triol previously isolated from Chrozophora oblique, 16) while 9 proved to be (6S,9R)-roseoside, 17) a norterpenoid with the megastigmane skeleton isolated for the first time from the Cleomaceae.…”

mentioning

confidence: 99%

Hepatoprotective Constituents from Cleome droserifolia

2009

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Cleome droserifolia (FORSSK) DEL. (Cleomaceae), known locally in Saudi Arabia as Al-Samwa, is distributed on rocky slopes and ledges in northwestern Saudi Arabia.1) C. droserifolia leaves extract have anti-schistosomiasis activity.2) The plant extract also has a hypoglycemic effect through potentiation of peripheral, hepatic insulin sensitivity and diminishing intestinal glucose absorption.3,4) Treatment of hepatocytes culture with the plant extract resulted in reduction in cell viability; however, the level of albumin was not affected.5) Previous phytochemical study of C. droserifolia indicated the presence of sesquiterpenes, steroids and flavonoids. [6][7][8] Screening of plants used in Saudi folk medicine as remedy for liver problems is one of our research interest. [9][10][11] In the present study biologically directed phytochemical study of the ethanol extract of C. droserifolia was conducted. Results and DiscussionIn our search for hepatoprotactive compounds from plants used in Saudi folk medicine as remedy for liver problems, the ethanol extract of the aerial parts of C. droserifolia showed 35.87, 26.8, 21.9 and 34.8% reduction at a dose of 500 mg/kg body weight in the level of serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and bilirubin, respectively. The ethanol extract was subjected to liquid-liquid partitioning; each fraction was tested for hepatoprotective activity. Biologically directed chromatographic purification of the active fractions was conducted and resulted in the isolation of 1-9. Compounds 2-8 were tested biologically, while the amount of 1 and 9 were not enough for biological study.Compounds 1 and 2 were identified as the guaiane sesquiterpenes buchariol previously isolated from an Egyptian collection of C. droserifolia 7) and 6-hydroxynardol (teucladiol) isolated from Teucrium leucocladum.12) Compounds 4-6 were identified as 5,3Ј-dihydroxy-3,6,7,4Ј,5Ј-pentamethoxyflavone, 5Ј-hydroxy-3,6,7,3Ј,4Ј,5Ј-hexamethoxyflavone; both previously reported from C. droserifolia 13) ; and luteolin, 14) respectively. Sitosterol-3-O-[b-D-glucopyranoside] (daucosterol) (3) was identified by comparison with literature data.15) Compound 7 was identified as the dolabellane diter-,18-triol previously isolated from Chrozophora oblique, 16) while 9 proved to be (6S,9R)-roseoside, 17) a norterpenoid with the megastigmane skeleton isolated for the first time from the Cleomaceae.The UV data of 8 in MeOH (l max : 354, 268, 255 nm) was diagnostic for a flavonol skeleton. 19) In addition, the 1 H-NMR spectrum showed a methoxyl signal at d H 3.85 and two sugars as indicated from the two anomeric protons at d H 5.56 and 5.58 ppm. The UV bathochromic shifts with NaOMe (l max : 398 nm), AlCl 3 /HCl (l max : 401, 359, 299 and 268 nm) indicated 3,5,4Ј free hydroxyl groups. The failure of 8 to produce any shift in band II with NaOAc indicated a substituted C-7.18) The position of the methoxyl group at C-3Ј was indicated from the heteronuclear multiple...

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Phenolic and terpenoid compounds from Chione venosa (sw.) urban var. venosa (Bois Bandé)

Cited by 44 publications

References 29 publications

Compounds fromSedum caeruleumwith antioxidant, anticholinesterase, and antibacterial activities

Compounds fromSedum caeruleumwith antioxidant, anticholinesterase, and antibacterial activities

Phytochemical Study and Antiprotozoal Activity of Compounds Isolated fromThalia geniculata.

Hepatoprotective Constituents from Cleome droserifolia

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