Phenolic aporphine-benzylisoquinoline alkaloids from Thalictrum faberi

Lin, Luxiang; Hu, Shufang; Chu, Min; Chan, Tze-Ming; Chai, Heebyung; Angerhofer, Cindy K.; Pezzuto, John M.; Cordell, Geoffrey A.

doi:10.1016/s0031-9422(98)00580-9

Cited by 23 publications

(22 citation statements)

References 16 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, maesanin (1) and maesanol (3) demonstrated moderate activities against human oral epidermoid carcinoma (KB) and vinblastine-resistant KB in the presence of vinblastine [KB-V (+VLB)] with ED 50 values at 5.9 and 6.6 µg/mL, and 3.7 and 4.4 µg/mL, respectively (vs colchicine: ED 50 values 0.2 and 0.6 µg/mL, plumbagin: ED 50 values 1.6 and 1.5 µg/mL, respectively). On the other hand, dihydromaesanin (2) showed a more selective and strong cytotoxicity against hormone-dependent (8) a SK-MEL: human malignant melonoma; KB = human epidermoid carcinoma; BT-549 = human ductal carcinoma; SK-OV-3 = human ovary carcinoma; VERO = (Kidney, African green monkey) used as normal cell line; b LU-1: human lung cancer; *KB = human oral epidermoid carcinoma; KB-V (+VLB) = vinblastine-resistant KB in the presence of vinblastine; LNCaP = hormone-dependent human prostatic cancer; ZR-75-1 = hormone-dependent human breast cancer ZR-75-1; c Positive limits (Lin et al 1999) = ED 50 < 5.0 µg/mL for LU-1, KB*; KB-V (+VLB), LNCaP and ZR-75-1. -= Inactive.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Cytotoxic and antioxidant activities of alkylated benzoquinones from Maesa lanceolata

Muhammad

Takamatsu

Walker

et al. 2003

Phytotherapy Research

View full text Add to dashboard Cite

The natural and semi-synthetic analogs of substituted 1,4-benzoquinones were evaluated for in vitro cytotoxic and antioxidant activities. Maesanin, dihydromaesanin, maesanin dimethyl ether and isomeric mixtures of 3-[(Z)-10'-pentadecenyl]-benzoquinone derivatives exhibited cytotoxic activity against HL-60 cell line (IC50 values 4.5, 2.2, 0.43 and 2.8 microg/mL, respectively), while it was found to be inactive against ROS (Reactive Oxygen Species) generation in HL-60. In contrast, the isomeric acylated benzoquinones with shorter alkyl substituents, namely, 2-acetoxy-5-hydoxy-6-methyl-3-tridecyl-1,4-benzoquinone and 2-hydoxy-5-acetoxy-6-methyl-3-tridecyl-1,4-benzoquinone showed most prominent antioxidant and antiproliferative effect on HL-60 (IC50 values 6.2 and 2.2 microg/mL, respectively), as well as cytotoxicities against SK-MEL, KB, BT-549 and SK-OV-3 carcinomas (IC50 values <1.1-4.2 microg/mL). All benzoquinones were found to be inactive against cell aggregation and cell adhesion assays, thus showing no effect on immune responses and inflammation.

show abstract

Section: Resultsmentioning

confidence: 99%

“…The cytotoxic agents doxorubicin and 5-fluorouracil were used as positive controls, while DMSO is used as negative (vehicle) control. The chemoprevention assay of the crude extracts and pure compounds against human lung cancer (LU-1), human (Lin et al, 1999).…”

Section: Introductionmentioning

confidence: 99%

Cytotoxic and antioxidant activities of alkylated benzoquinones from Maesa lanceolata

Muhammad

Takamatsu

Walker

et al. 2003

Phytotherapy Research

View full text Add to dashboard Cite

show abstract

“…The six phenolic aporphine-benzylisoquinoline alkaloids, 3hydroxy-6'-desmethyl-9-O-methylthalifaboramine 59, 3hydroxythalifaboramine 60, 6'-desmethylthalifaboramine 61, 3,5'-dihydroxythalifaboramine 62, 5'-hydroxythalifaboramine 63 and 3-hydroxy-6'-desmethylthalifaboramine 64 were isolated from the roots of Thalictrum faberi which were used to treat stomach cancer. Similar to other thalifaberinetype aporphine-benzylisoquinonline alkaloids, all of these alkaloids showed cytotoxicity [31].…”

Section: Alkaloidsmentioning

confidence: 64%

Cytotoxic Anticancer Candidates from Natural Resources

Kim¹,

Park²

2002

CMCACA

112

View full text Add to dashboard Cite

Natural products have been regarded as important sources that could produce potential chemotherapeutic agents. Over 50% of anticancer drugs approved by United States Food and Drug Administration since 1960 were originated from the natural resources, especially from terrestrial plants. Based on cytotoxicity bioassay, over 400 compounds have been isolated from plants, marine organisms and microorganisms from the period of 1996 to 2000. Recently, interest of natural product research has slowly moved to marine organisms. As a result, almost 50% of reported cytotoxic compounds were isolated from marine organisms such as sponges and corals. Also, traditional cytotoxic compounds of acetogenins, alkaloids and terpene skeletons have been reported continuously. In this review, we will present the cytotoxic compounds obtained from natural sources from 1996 to 2000, and the structures and cytotoxic activity of natural compounds isolated from territorial, marine and microorganism resources.

show abstract

“…Physiological activity may be due to one or more than one group of constituents. Several investigations have been published in the field of antiplas-modials of plant origin related to different bioaditive functional groups classified as: terpenoids; 3–5,12 alkaloids; 3,13–16 unsaturated fatty acids; 17 volatile oils 18,19 and phenolic compounds including flavonoids 4,17 and quinones. 20,21…”

Section: Discussionmentioning

confidence: 99%

Antiplasmodial Activity of Some Medicinal Plants Used in Sudanese Folk-medicine

Ahmed

Nour

Mohammed

et al. 2010

Environ�Health�Insights

View full text Add to dashboard Cite

Ten plants indigenous to Sudan and of common use in Sudanese folk-medicine, were examined in vitro for antimalarial activity against schizonts maturation of Plasmodium falciparum, the major human malaria parasite. All plant samples displayed various antiplasmodial activity. Three plant extracts caused 100% inhibition of the parasite growth at concentrations of plant material ≤ 500 ug/ml. The two most active extracts that produced 100% inhibition of the parasite growth at concentration of plant material ≤ 50 μg/ml were obtained from the seeds of Nigella sativa and the whole plant of Aristolochia bracteolata. The ten plants were phytochemically screened for their active constituents. The two most active plants showed the presence of sterols, alkaloids and tannins.

show abstract

Phenolic aporphine-benzylisoquinoline alkaloids from Thalictrum faberi

Cited by 23 publications

References 16 publications

Cytotoxic and antioxidant activities of alkylated benzoquinones from Maesa lanceolata

Cytotoxic and antioxidant activities of alkylated benzoquinones from Maesa lanceolata

Cytotoxic Anticancer Candidates from Natural Resources

Antiplasmodial Activity of Some Medicinal Plants Used in Sudanese Folk-medicine

Contact Info

Product

Resources

About