Phenolic composition, antioxidant and anti-fibrotic effects of Sesbania grandiflora L. (Agastya) – An edible medicinal plant

Saravanakumar, Arthanari; Periyasamy, P.C.

doi:10.4103/ayu.ayu_198_19

Cited by 3 publications

(3 citation statements)

References 32 publications

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“…Notably, the DPPH assay demonstrated that Sesbania grandiflora exhibited significant radical scavenging effects that intensified with increasing concentration. 18 The results of our study show similar effect in terms of increased hair density and thickness.…”

Section: Discussionsupporting

confidence: 79%

“…14,15 The test treatment used in the present study contains Sesbania grandiflora extract (commonly known as Agati) [(SesZen-Bio ® , Zywie Ventures Private Limited), Zenherb Labs Private Limited, India] which is standardised for 0.5% biotin and contains various cofactors which are used for their antioxidant, astringent, antihistaminic, anxiolytic, anticonvulsive and febrifugal activities. [16][17][18] The leaves and flowers of Agati are abundant in vitamins (biotin, A, C, B2, etc) and minerals (zinc and selenium), whereas the bark and flowers are rich in polyphenols. 19 Biotin, alternatively recognized as Vitamin B7 or H (with H derived from "Haar und Haut," German for "hair and skin"), is a water-soluble B vitamin serving as a crucial cofactor for numerous carboxylases which play pivotal role in the cellular metabolism of fatty acids, amino acids, and gluconeogenesis.…”

Section: Introductionmentioning

confidence: 99%

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A prospective, randomized double-blind, placebo-controlled study for safety and efficacy of SesZen-Bio™: a proprietary Sesbania grandiflora extract in managing hair and scalp health in healthy adults

Upadhyay,

Gadani,

Badak

et al. 2024

Int J Clin Trials

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Background: Hair loss, a common multifactorial condition affecting both genders, results from causes like extrinsic factors (pollution, sun, humidity, and temperature), nutritional variation, or intrinsic factors such as ageing, heredity, hormonal and medical conditions. Some of the damages caused by these factors can be effectively managed with multivitamins, minerals, antioxidant natural products. Present study assessed use of standardised herbal Sesbania grandiflora extract for improving hair density, hair thickness and scalp health along with a serum biomarker to establish the probable mechanism of action. Methods: The study was approved by the ethics committee and was conducted as per standard national regulations. 51 randomized subjects (mean age: 39.40±5.80 years) received either test-treatment or placebo for consecutive 56 days. Instrumental assessments included a phototrichogram to assess hair density, thickness, and scalp condition. Results: SesZen-BioTM which is derived from Sesbania grandiflora extracts showed an improvement in hair density, hair thickness and ferritin in 8 weeks of usage suggesting it stimulates the keratin production which resulted in improved follicle growth. By day 56 of usage, hair density and thickness improved by 58.92±28.69 cm2 and 3.68±2.69 μm respectively from baseline (both p<0.0001) in the treatment group. This indicates towards 25% improvement in hair density, 16.94% in hair thickness and almost 72% volunteers indicated an improvement in hair health along with 27% increase in serum ferritin. Conclusions: Sesbania grandiflora extract -SesZen-Bio® showed beneficial nutritional effects on research subjects, proving its usefulness as a well-tolerated and efficient daily supplement to improve hair health.

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Section: Discussionsupporting

confidence: 79%

Section: Introductionmentioning

confidence: 99%

A prospective, randomized double-blind, placebo-controlled study for safety and efficacy of SesZen-Bio™: a proprietary Sesbania grandiflora extract in managing hair and scalp health in healthy adults

Upadhyay,

Gadani,

Badak

et al. 2024

Int J Clin Trials

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show abstract

“…Flowers are reportedly used as an emollient, astringent, and antipyretic property. Additionally, flowers can treat intermittent fevers, running nose, inflammation of the mucous membrane inside the nose, and liver and spleen disorders [19]. The leaves of S. grandiflora are highly nutritious and contain several vitamins (vitamins A, E, and C), minerals, and amino acids.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of toxicity studies of Sesbania grandiflora leaves extracts in Wistar albino rats

Sharma,

Semwal,

Mazumder

2024

JAPR

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Objective: Sesbania grandiflora is a well-known medicinal plant belonging to the family Fabaceae, and it is used to treat several disorders. The current investigation aims to analyze the negative consequences of short and long-term administration of hydroalcoholic extract of S. grandiflora leaf in experimental animals. Materials and Methods: Acute and subacute toxicity were the two phases in which the entire examination was completed. In phase first, acute toxicity was performed at the dose of (2000, mg/kg) and adverse effect was recorded. However, in sub-acute toxicity the effect of different doses of (1000, 2000 and 5000 mg/kg) were studied for twenty-eight days. Animals were euthanized on the last day of the investigation, and selected internal body organs and samples of the blood were taken from each animal for histological, biochemical, and haematological analysis. Results: The result of the current investigation showed that the LD50 of S. grandiflora was observed more than 2000 mg/kg, Furthermore, experimental animals did not experience any mortality or alterations in their behavioral patterns when S. grandiflora was administered repeatedly at 1000, 2000, and 5000 mg/kg or in a single dose of 2000 mg/kg. Besides this, S. grandiflora also did not significantly modify any of the biochemical or haematological markers, or the histological analyses of selected organs. Conclusion: The results of the above research revealed that the orally administration of S. grandiflora extract did not exhibit any apparent harmful effects in experimental animals. Hence, S. grandiflora could be regarded as a safe and can be used for the therapeutic purpose in human being.

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Hepatoprotective effect of flavonoid rich fraction of Sesbania grandiflora: Results of In vivo, in vitro, and molecular docking studies

Kuttiappan,

Chenchula,

Vanangamudi

et al. 2024

Journal of Ayurveda and Integrative Medicine

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Phenolic composition, antioxidant and anti-fibrotic effects of Sesbania grandiflora L. (Agastya) – An edible medicinal plant

Cited by 3 publications

References 32 publications

A prospective, randomized double-blind, placebo-controlled study for safety and efficacy of SesZen-Bio™: a proprietary Sesbania grandiflora extract in managing hair and scalp health in healthy adults

A prospective, randomized double-blind, placebo-controlled study for safety and efficacy of SesZen-Bio™: a proprietary Sesbania grandiflora extract in managing hair and scalp health in healthy adults

Evaluation of toxicity studies of Sesbania grandiflora leaves extracts in Wistar albino rats

Hepatoprotective effect of flavonoid rich fraction of Sesbania grandiflora: Results of In vivo, in vitro, and molecular docking studies

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