Phenolic compounds as beneficial phytochemicals in pomegranate ( Punica granatum L.) peel: A review

Singh, Balwinder; Singh, Jagir; Kaur, Amritpal; Singh, Narpinder

doi:10.1016/j.foodchem.2018.04.039

Cited by 387 publications

(284 citation statements)

References 85 publications

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“…It should be noted that current results were similar to that obtained by Abountiolas and Nascimento Nunes (), Cano‐Lamadrid et al. (), and Singh, Singh, Kaur, and Singh (), reporting that labelling information and formulation of some fruits drinks is not consistent with the levels of Pn and TPC.…”

Section: Resultssupporting

confidence: 83%

“…Most of the statements concerned antioxidants as reported in seven of the present samples. It should be noted that current results were similar to that obtained by Abountiolas and Nascimento Nunes (2018), Cano-Lamadrid et al (2016), and Singh, Singh, Kaur, and Singh (2018), reporting that labelling information and formulation of some fruits drinks is not consistent with the levels of Pn and TPC. Pearson correlation and principal component analysis (PCA).…”

Section: Chemical Parameterssupporting

confidence: 45%

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A Critical Overview of Labeling Information of Pomegranate Juice‐Based Drinks: Phytochemicals Content and Health Claims

Cano‐Lamadrid

Turkiewicz

Tkacz

et al. 2019

Journal of Food Science

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Punicalagin is responsible for over 50% of the antioxidant activity of pomegranate, but ellagic acid (EA) and total polyphenol content (TPC) are also key parameters regarding pomegranate bioactivity. Many juices and other drinks based on pomegranate take advantage from the widespread healthy image of this fruit, whereas their real content of bioactive phytochemicals is low. For that reason, the objective of this study was to compare the labelling information with the real phytochemical contents (TPC, punicalagin [Pn] [isomers α, β], and EA). Titratable acidity (TA), color density (CD), polymeric color (PC), and sensory profiles (trained panel) were assessed. The experimental ranges of TPC and Pn contents were 2.75 to 70.9 mg/g and traces to 3.18 mg/g, respectively. The percentage of pomegranate juice was highly correlated with the intensity of the pomegranate ID attribute (R = 0.85; p < 0.001), Pn content (R = 0.71; p < 0.001), and EA content (R = 0.36; p < 0.001). The experimental results showed a high variability in the content of bioactive compounds and the need to urge food companies to optimize processes and storage conditions. Although no health claim for pomegranate has been authorized so far at the European Union, significant mismatches among labelling and bioactive compounds content are misleading consumers. Practical Application Pomegranate juice and nectar producers need to evaluate the real content of bioactive Pn, EA, and TPC in their products to optimize formulation, heat treatment, packaging and storage conditions to guarantee high levels of bioactive compounds during shelf life. Producers’ organizations may benefit from harmonizing Pom products labelling, so they may fulfill consumer expectations and may be ready if health claims are finally authorized for these products. The development of a new sensory quality marker will be an interesting option.

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Section: Resultssupporting

confidence: 83%

Section: Chemical Parameterssupporting

confidence: 45%

A Critical Overview of Labeling Information of Pomegranate Juice‐Based Drinks: Phytochemicals Content and Health Claims

Cano‐Lamadrid

Turkiewicz

Tkacz

et al. 2019

Journal of Food Science

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“…It was demonstrated that the use of extracts or juices of pomegranate, strawberries, watermelon, and Garcinia Indica fruit, which are popular in Hindu medicine, led to an improvement in cerebral antioxidative potential. The antioxidative properties of fruit result from the presence of large amounts of phenolic compounds, primarily phenolic acids and catechins, epicatechins, flavan-3-ols, kaempferol, quercetin, and luteolin [132,152]. Apart from the same, the mentioned fruit also contain a number of other substances with known antioxidative properties: vitamins C and E, β-carotene, selenium, and anthocyanins [132,153].…”

Section: Phenolic Compoundsmentioning

confidence: 99%

The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance

et al. 2020

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Neurodegenerative diseases are progressive diseases of the nervous system that lead to neuron loss or functional disorders. Neurodegenerative diseases require long-term, sometimes life-long pharmacological treatment, which increases the risk of adverse effects and a negative impact of pharmaceuticals on the patients' general condition. One of the main problems related to the treatment of this type of condition is the limited ability to deliver drugs to the brain due to their poor solubility, low bioavailability, and the effects of the blood-brain barrier. Given the above, one of the main objectives of contemporary scientific research focuses on the prevention of neurodegenerative diseases. As disorders related to the competence of the antioxidative system are a marker in all diseases of this type, the primary prophylactics should entail the use of exogenous antioxidants, particularly ones that can be used over extended periods, regardless of the patient's age, and that are easily available, e.g., as part of a diet or as diet supplements. The paper analyzes the significance of the oxidoreductive balance in the pathogenesis of neurodegenerative diseases. Based on information published globally in the last 10 years, an analysis is also provided with regard to the impact of exogenous antioxidants on brain functions with respect to the prevention of this type of diseases.

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“…Pomegranate ( Punica granatum L.) is a fruit crop that has abundant polyphenols 9,10 . POMx, a commercial dietary ingredient made from pomegranate extract was” generally recognized as being safe” (GRAS) by the United States Food and Drug Administration (FDA), and was sold before standardizing its polyphenolic ellagitannin content 11 .…”

Section: Introductionmentioning

confidence: 99%

Pomegranate extract inhibits migration and invasion of oral cancer cells by downregulating matrix metalloproteinase‐2/9 and epithelial‐mesenchymal transition

Peng

Hsiao

Lan

et al. 2020

Environmental Toxicology

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Discovering drug candidates for the modulation of metastasis is of great importance in inhibiting oral cancer malignancy. Although most pomegranate extract applications aim at the antiproliferation of cancer cells, its antimetastatic effects remain unclear, especially for oral cancer cells. The aim of this study is to evaluate the change of two main metastasis characters, migration and invasion of oral cancer cells. Further, we want to explore the molecular mechanisms of action of pomegranate extract (POMx) at low cytotoxic concentration. We found that POMx ranged from 0 to 50 μg/mL showing low cytotoxicity to oral cancer cells. In the case of oral cancer HSC-3 and Ca9-22 cells, POMx inhibits wound healing migration, transwell migration, and matrix gel invasion.Mechanistically, POMx downregulates matrix metalloproteinase (MMP)-2 and MMP-9 Sheng-Yao Peng and Chien-Chou Hsiao contributed equally to this work.

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Phenolic compounds as beneficial phytochemicals in pomegranate ( Punica granatum L.) peel: A review

Cited by 387 publications

References 85 publications

A Critical Overview of Labeling Information of Pomegranate Juice‐Based Drinks: Phytochemicals Content and Health Claims

A Critical Overview of Labeling Information of Pomegranate Juice‐Based Drinks: Phytochemicals Content and Health Claims

The Role of Dietary Antioxidants in the Pathogenesis of Neurodegenerative Diseases and Their Impact on Cerebral Oxidoreductive Balance

Pomegranate extract inhibits migration and invasion of oral cancer cells by downregulating matrix metalloproteinase‐2/9 and epithelial‐mesenchymal transition

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