Phenolic Compounds from <i>Limonium pruinosum</i>

Boudermine, Sihem; Malafronte, Nicola; Mencherini, Teresa; Esposito, Tiziana; Aquino, Rita Patrizia; Beghidja, Noureddine; DʼAmbola, Massimiliano; Vassallo, Antonio

doi:10.1177/1934578x1501000228

Cited by 5 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mill species showed a diversity of secondary metabolites accumulation in their tissues, such as carbonyl compounds, naphthoquinone, tannins and alkaloids [18] . Recently, a new phenolic compound was isolated from all parts of L. pruinosum Kuntze [19] …”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Comparative Analysis of Organic Extracts Bioactivity from Two Limonium. Mill Species Growing Wild in Tunisian Salty Marshes

Rahmani,

Debouba,

Aydi

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

Limonium. Mill is a genus of flowering plants belonging to the Plumbaginaceae family. The present study aimed to compare two Limonium species (L. pruinosum Kuntze and L. tunetanum (Barratte & Bonnet) Maire) in terms of their chemical composition and bioactivity. Chemical profiling showed that the methanolic (MeOH) extracts of both species were the most enriched with total phenolic (TP) and total flavonoid (TF) contents. The TFC were higher in L. tunetanum compared to L. pruinosum. HPLC‐DAD analysis showed that distinctly the gallic acid and L‐tyrosine 7‐amido‐4‐methylcoumarin were the main compounds for L. pruinosum and L. tunetanum, respectively. For both Limonium. Mil species, the MeOH extracts displayed the highest antioxidant with IC50 of 7.7 and 8.4 μg/mL for L. pruinosum and L. tunetanum, respectively. The highest anti‐15‐lipoxygnase activity was recorded in the ethyl acetate (IC50=14.2 μg/mL) and Methanol (IC50=15.6 μg/mL) extracts for L. pruinosum. However, for L. tunetanum the best activity was recorded for dichloromethane extract (IC50=10.4 μg/mL). L. pruinosum extracts displayed the highest cytotoxic activity against MCF‐7 and HCT‐116 cell lines compared to L. tunetanum ones. The obtained bioactivity discrepancy between Limonium. Mill species was discussed in relation to the organic extract chemical richness.

show abstract

Section: Resultsmentioning

confidence: 99%

“…Generally, antioxidant activity was attributed to plant richness in polyphenols acting as a donating hydrogen or as free radical trap into their aromatic rings. Recently, Boudermine et al [19] isolated a new phenolic compound from all parts of L. pruinosum Kuntze with high potency in scavenging free radicals. It seems that Limonium.…”

Section: Anti-dpph Activitymentioning

confidence: 99%

Comparative Analysis of Organic Extracts Bioactivity from Two Limonium. Mill Species Growing Wild in Tunisian Salty Marshes

Rahmani,

Debouba,

Aydi

et al. 2023

Chemistry & Biodiversity

View full text Add to dashboard Cite

show abstract

“…The active fractions TRIT 6 , TRIT 7 , and TRIT 8 from Triphala hydroalcoholic extract, obtained by MAE, were purified with RP-HPLC using MeOH–H 2 O (3 : 7) to produce compounds of phyllemblin (C 9 H 10 O 5 showed an [M-H] − ion at m/z 197.0531) [ 21 ] from TRIT 6 ; gallic acid (C 7 H 6 O 5 showed an [M-H] − ion at m/z 169.0217), cinnamic acid (C 9 H 8 O 2 showed an [M-H] − ion at m/z 147.0525), and 1,3,6-tri- O -galloyl- β -D-glucose (C 27 H 24 O 18 showed an [M-H] − ion at m/z 635.0969) [ 22 , 23 ] from TRIT 7 ; and 1,2,3,6-tetra- O -galloyl- β -glucose (C 34 H 28 O 22 showed an [M-H] − ion at m/z 787.1075), 1,2,3,4,6-penta- O -galloyl- β -D-glucose (C 41 H 32 O 26 showed an [M-H] − ion at m/z 939.1187), p-coumaric acid (C 9 H 8 O 3 showed an [M-H] − ion at m/z 163.0476) [ 23 ], and chebulinic acid (C 41 H 32 O 27 showed an [M-H] − ion at m/z 955.1134) [ 24 ] from TRIT 8 ( Figure 1 ), molecules known in the literature for their antimicrobial activity [ 25 – 31 ].…”

Section: Resultsmentioning

confidence: 99%

Evaluation of Antimicrobial Activity of Triphala Constituents and Nanoformulation

Omran

Bader

Porta

et al. 2020

Evidence-Based Complementary and Alternative Medicine

Self Cite

View full text Add to dashboard Cite

The prevalence of nosocomial infections due to multidrug resistant (MDR) bacterial strains is associated with high morbidity and mortality. Folk medicine and ethnopharmacological data can provide a broad range of plants with promising antimicrobial activity. Triphala, an Ayurvedic formula composed of three different plants: Terminalia chebula Retz., Terminalia bellirica (Gaertn.) Roxb. (Combretaceae), and Phyllanthus emblica L. (Phyllanthaceae), is used widely for various microbial infections. Various extraction techniques were applied in the extraction of the biologically active constituents of Triphala in order to compare their efficiency. Microwave-assisted extraction (MAE) was shown to be the most efficient method based on yield, extraction time, and selectivity. The Triphala hydroalcoholic extract (TAE) has been chemically characterized with spectroscopic and chromatographic techniques. Triphala hydroalcoholic extract was evaluated alone or with carvacrol. Different drug formulations including cream and nanoemulsion hydrogel were prepared to assess the antimicrobial activity against selected microorganism strains including Gram-positive and Gram-negative bacteria and fungi. We used a lipophilic oil of carvacrol (5 mg/mL) and a hydrophilic TAE (5 mg/mL) ingredient in a dosage form. Two solutions were created: hydrogel containing nanoemulsion as a lipophilic vector dispersed in the gel as a hydrophilic vehicle and a cream formulation, an oil-in-water emulsion. In both cases, the concentration was 250 mg of active ingredient in 50 mL of final formulation. The formulas developed were stable from a physical and chemical perspective. In the nanoemulsion hydrogel, the oil droplet size ranged from 124 to 129 nm, with low polydispersity index (PdI) 0.132 ± 0.013 and negative zeta potential −46.4 ± 4.3 mV. For the cream, the consistency factor (cetyl alcohol and white wax) induced immobilization of the matrix structure and the stability. Triphala hydroalcoholic extract in drug nanoformulation illustrated might be an adjuvant antimicrobial agent for treating various microbial infections.

show abstract

“…The differences in the concentration of phenols in the studied species are associated with various molecular, physiological, phylogenetic, and morphological structures that emerge as a response to the influence of environmental factors [16], increasing under increased salt concentrations and drought [17]. High content of total phenolic compounds of the Limonium and Polygonum species, including flavonoids, is well documented [18][19][20][21][22].…”

Section: Total Phenolic Contentmentioning

confidence: 91%

Coastal Halophytes: Potent Source of Bioactive Molecules from Saline Environment

Stanković

Stojanović-Radić

Jakovljević

et al. 2023

Plants

View full text Add to dashboard Cite

This study represents a comparative analysis of secondary metabolites content, antioxidant, and antimicrobial activity of 24 halophytes from coastal saline habitats of the Balkan Peninsula (Montenegro, Albania, and Greece). Total content of phenolics, flavonoids, tannins, anthocyanins, antioxidant, and antimicrobial activity was determined for dry methanolic (DME) and crude water extracts (CWE) and compared with well-known medicinal plants. The total phenolic content ranged from 13.23 to 376.08 mg of GA/g of DME, and from 33.68 to 511.10 mg/mL of CWE. The content of flavonoids ranged from 12.63 to 77.36 mg of RU/g of DME, and from 12.13 to 26.35 mg/mL of CWE. Total tannins and anthocyanins varied from 0.05 to 2.44 mg/mL, and from 1.31 to 39.81 µg/L, respectively. The antioxidant activity ranged from 1147.68 to 15.02 µg/mL for DME and from 1613.05 to 21.96 µg/mL for CWE. The best antioxidant properties, and the highest content of phenolic compounds, were determined for Polygonum maritimum and Limonium vulgare with values similar to or higher compared to the medicinal plants. Halophytes with significant antimicrobial potential were Limonium vulgare, L. angustifolium, and Artemisia maritima. Some of the analyzed coastal halophytes can be considered rich natural sources of phenolic compounds, with favorable antioxidative and antimicrobial properties.

show abstract

Phenolic Compounds from Limonium pruinosum

Cited by 5 publications

References 13 publications

Comparative Analysis of Organic Extracts Bioactivity from Two Limonium. Mill Species Growing Wild in Tunisian Salty Marshes

Comparative Analysis of Organic Extracts Bioactivity from Two Limonium. Mill Species Growing Wild in Tunisian Salty Marshes

Evaluation of Antimicrobial Activity of Triphala Constituents and Nanoformulation

Coastal Halophytes: Potent Source of Bioactive Molecules from Saline Environment

Contact Info

Product

Resources

About