Phenolic compounds from jaboticaba (Plinia jaboticaba (Vell.) Berg) ameliorate intestinal inflammation and associated endotoxemia in obesity

Rodrigues, Larissa; Donado‐Pestana, Carlos M.; Moura, Márcio Hércules Caldas; Silva, Rafaela Rossi e; Pessoa, Érika Vicência Monteiro; Genovese, Maria Inês

doi:10.1016/j.foodres.2021.110139

Cited by 19 publications

(10 citation statements)

References 45 publications

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“…In particular, the protein levels of caspase-1, IL-1β and IL-18, present in the NLRP3 cascade signal, were significantly decreased, as compared with the obese group, in the kidneys, 46 liver 50 and intestine 51 (based on protein levels in the first case and mRNA expression in the other two). Nevertheless, the levels of NLRP3 measured as protein in the kidneys 46 and mRNA expression in the intestine 51 remained unaltered as compared with the obese group. However, an increased expression of inflammasome components should not be used as proof of inflammasome activation.…”

Section: Obesitymentioning

confidence: 92%

“…It has been widely established that an intrinsic characteristic of obesity, besides an excess of fat deposition, is the presence of a state of chronic, low-grade inflammation where multiple molecular pathways are involved, including the NLRP3 inflam-masome. 45 Six studies [46][47][48][49][50][51] explored the specific role of polyphenols as NLRP3 inflammasome modulators in an obesity context (Table 1). They were all preclinical studies, five in mice and one in rats.…”

Section: Obesitymentioning

confidence: 99%

“…50 Obesity was induced by an HFD except for one study, which used a high-fat high-sucrose diet (HFHSD). 51 Only one study tested a pure polyphenol, morin, 50 while the other ones were focused on extracts from the seaweed Ecklonia cava , 46 red raspberry, 48 or the tropical fruit jaboticaba, 51 and on whole materials from grape seed 47 or red raspberry. 49 The study duration ranged from 8 50 to 14 51 weeks.…”

Section: Current In Vivo Evidence On Polyphenols As Nlrp3 Inflammasom...mentioning

confidence: 99%

See 2 more Smart Citations

Polyphenols as NLRP3 inflammasome modulators in cardiometabolic diseases: a review ofin vivostudies

Villalva,

Martínez-García,

Jaime

et al. 2023

Food Funct.

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Section: Obesitymentioning

confidence: 92%

Section: Obesitymentioning

confidence: 99%

Section: Current In Vivo Evidence On Polyphenols As Nlrp3 Inflammasom...mentioning

confidence: 99%

See 1 more Smart Citation

Polyphenols as NLRP3 inflammasome modulators in cardiometabolic diseases: a review ofin vivostudies

Villalva,

Martínez-García,

Jaime

et al. 2023

Food Funct.

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“…The extract inhibited inflammatory intermediates (TNF-α, TLR-4 and NF-κB) and showed a possible partial modulation of the inflammasome pathway in the colon. Thus, the study indicated a direct anti-inflammatory effect in the gut of obese mice, suggesting an improvement of metabolic endotoxemia (Rodrigues et al, 2021). Lenquiste et al (2019) concluded that freeze-dried jabuticaba bark and jabuticaba tea treatments reduced weight gain and adiposity, improved insulin sensitivity, increased HDL, and prevented long-term hepatic steatosis in obese rats.…”

Section: Berriesmentioning

confidence: 94%

Obesity mechanisms and importance of bioactive compounds from fruits in its regulation – a narrative review

Martinez

Almeida

Lima

et al. 2022

RSD

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A balanced diet is essential in obesity control. Fruits stand out for the presence of various bioactive compounds, which represent promising tools in the prevention and treatment of various pathologies. In obesity, fruits phytochemicals present are related to different important mechanisms of action, such as antioxidant and anti-inflammatory activity. This narrative review aims to understand the main physiological alterations of obesity and the effects of bioactive compounds in fruits on them, identifying the best-known substances and their likely mechanisms of action on the main biomarkers. The research was carried out in the Google Scholar, Scielo, Pubmed and Science Direct databases, considering reviews published since 2015 and experimental studies since 2010. Inflammatory cytokines and adipokines are considered primary biomarkers of obesity, and are currently also considered the insulin resistance, lower glucose tolerance, oxidative stress, gut microbiota, nutrients and microRNAs. Three groups of fruits stood out for their effects: Citrus fruits, berries and tropical fruits, sources mainly of flavonoids, anthocyanins and carotenoids. Experimental results indicate that fruits and their compounds can help in the prevention and treatment of obesity through the regulation of inflammatory cytokines and adipokines involved in the mechanisms of this disease, as well as antioxidant properties and modulation of lipogenesis. More clinical studies are needed to understand the biochemical mechanisms involved, in order to favor not only the production of specific supplements but also the best clinical dietary prescription.

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“…In fruits, phenolic compounds are secondary metabolites responsible for the maturity degree, senescence, and defense against biotic and abiotic stressors (Bortolini, Barros, et al, 2022). In human health, these compounds present in jaboticaba are associated with chemopreventive properties (Holkem et al, 2020), anti‐inflammatory, hypoglycemic, hypolipidemic, and analgesic activities (da Silva Brito et al, 2021), reducing intestinal inflammation and associated endotoxemia in obesity (Rodrigues et al, 2021), among other health benefits. Despite the necessity of isolation and purification of bioactive compounds, methods of extraction such as microwave‐assisted, ultrasound‐assisted, and high hydrostatic pressure have been explored by researchers (Barba et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

Biosorption of phenolic compounds from Plinia cauliflora seeds in residual yeast: Kinetic, equilibrium, and bioaccessibility studies

Maroldi

Maciel

Rossetto

et al. 2022

Food Processing Preservation

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This study aimed to evaluate the biosorption mechanisms of bioactive compounds from jaboticaba (Plinia cauliflora) seeds adsorbed on residual Saccharomyces cerevisiae. The bioaccessibility of bioactive compounds before and after the biosorption process was tested using the simulated gastrointestinal digestion technique. The biosorption process was evaluated at different solution pH values (2, 4, 6, and 8). In the present study, the biosorption occurred more favorably in an acid solution medium, and the highest adsorption capacity was found at pH 2 (qe = 49 mg g−1). In alkaline conditions (pH > 7), the biosorption was disfavored. The biosorption kinetics of phenolic compounds from jaboticaba seed extract in yeasts showed a fast equilibrium time (45 min). In addition, 80% of biosorption occurred within the first 15 min. Regarding the isotherm studies, the increased adsorption capacity observed was directly proportional to the increase in the concentration of the initial solution, presenting an L‐type curve characteristic of monolayer adsorption. The Sips and Jovanovic monolayer models suggest that the maximum adsorption capacity (q) was 75 mg g−1. According to the separation factor (RL) of the Langmuir model, the adsorption of the phenolic compounds extracted from the jaboticaba seeds occurred favorably (RL = 0.509). In addition, the concentration of total phenolic compounds after simulated gastrointestinal digestion was reduced in crude and biosorbed extracts, with bioaccessibility values of 5.37 and 2.64, respectively. However, the concentration of these total compounds increased after intestinal digestion of the biosorbed yeast. The biosorption equilibrium time was reached at 45 min, and the maximum adsorption capacity for the concentrations studied was 50 mg g−1 at pH 2. These results show that S. cerevisiae is a biosorbent capable of protecting and releasing compounds during gastrointestinal digestion and acts as a polyphenol delivery system. Novelty impact statement Yeasts biosorbed with bioactive compounds of plants can be used as a delivery system of secondary metabolites where the enriched biomass act in preserving the antioxidant and bioaccessibility of the molecules.

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Phenolic compounds from jaboticaba (Plinia jaboticaba (Vell.) Berg) ameliorate intestinal inflammation and associated endotoxemia in obesity

Cited by 19 publications

References 45 publications

Polyphenols as NLRP3 inflammasome modulators in cardiometabolic diseases: a review ofin vivostudies

Polyphenols as NLRP3 inflammasome modulators in cardiometabolic diseases: a review ofin vivostudies

Obesity mechanisms and importance of bioactive compounds from fruits in its regulation – a narrative review

Biosorption of phenolic compounds from Plinia cauliflora seeds in residual yeast: Kinetic, equilibrium, and bioaccessibility studies

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