Phenolic Compounds of Serratula Centauroides and Anxiolytic Effect

Nikolaev, Sergei

doi:10.31925/farmacia.2019.3.19

Cited by 4 publications

(3 citation statements)

References 17 publications

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“…Three basic compounds of R. uniflorum extracts were 5-O-caffeoylquinic acid, 4-O-caffeoylquinic acid and 20-hydroxyecdysone with the level of content at 63.59, 25.11 and 17.83 mg/g, respectively, as well in S. centauroides extract the major compounds were 5-O-caffeoylquinic acid (40.85 mg/g), 20-hydroxyecdysone (27.43 mg/g) and apigenin-7-O-glucuronide (18.27 mg/g) (Table 1). The remaining identified compounds were mainly di-O-caffeoylquinic acids and O-glycosylflavones found previously in herb of R. uniflorum [15,16,18,19].…”

Section: Hplc-dad-esi-ms Profiles Of Rhaponticum Uniflorum and Serratula Centauroides Extractsmentioning

confidence: 64%

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Rhaponticum uniflorum and Serratula centauroides Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress

et al. 2021

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In modern life, the use of plant stress-protectors has taken on particular significance due to the wide distribution of neurosis-like and neurotic diseases caused by neuroendocrine-immune system imbalance. Special attention has been paid to the plants containing ecdysteroids, i.e., hormone-like bioactive substances with high adaptogenic activity. The article deals with the study of bioactivity of two plant extracts as Rhaponticum uniflorum (L.) DC. and Serratula centauroides L. with a high content of ecdysteroids and phenolic compounds. The models of acute and chronic emotional stress in white rats were used to estimate the stress-protective activity of R. uniflorum and S. centauroides extracts. Both extracts showed the stress-protective effect via inhibiting the development of signs induced by single and long-term effects of stress factors. In acute stress, the development of Selye's triad signs was less pronounced against the background of the plant remedies introduction. In chronic stress, the extracts prevented the development of anxiety-depressive syndrome. Besides, R. uniflorum and S. centauroides extracts banned the development of stress-induced injuries in the brain cortex and had a neuroprotective effect on ischemia against chronic stress. The stress-protective effects of both plant extracts were based on a decrease of hyperactivation of the central stress-promoting systems (sympathoadrenal, hypothalamic-pituitary-adrenal) due to their GABA-mimetic effects. Peripheral mechanisms were connected with the inhibition of free radical oxidation processes and with an increase in the endogenous antioxidant system activity. Thus, R. uniflorum and S. centauroides extracts have a high potential to increase non-specific body resistance against acute and chronic emotional stress effects.

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Section: Hplc-dad-esi-ms Profiles Of Rhaponticum Uniflorum and Serratula Centauroides Extractsmentioning

confidence: 64%

“…Among other compounds, this plant also contains phenolic compounds, amino acids, fatty and organic acids and essential oils. Decoction of S. centauroides herb demonstrated hemostatic, anabolic, anti-hypoxic, nootropic and anxiolytic potential [19].…”

Section: Introductionmentioning

confidence: 99%

Rhaponticum uniflorum and Serratula centauroides Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress

et al. 2021

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“…Diazepam is a mild anticholinergic according to the classification of anticholinergic drugs [25]. It induces amnesia in laboratory animals [15,28]. Likewise, D. innoxia leaves extract was reported to contain tropanic alkaloids including scopolamine and hyoscyamine [10].…”

Section: Table IImentioning

confidence: 99%

Brain Protection and Anti-Amnesic Effects Assessment of Datura Innoxia Mill. Aqueous Extracts

Kinda¹

2020

FARMACIA

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Traditional plants are largely used in alternative medicine for many disorders treatment. However, some discussions regarding the safety of their usage exist. The present study aims to evaluate the anti-amnesic effect of Datura innoxia leaves aqueous extract, and the possible noxious impact of its use. Thus, there were evaluated the possible protective effects of the extract on the central nervous system, as well as its toxic effects, by using Wistar rats models and NMRI mice, respectively. The results are showing non-protective effects of the aforementioned extract in the behavioural tests, as well as in the levels of acetylcholinesterase, superoxide dismutase and catalase specific activity evaluation. Superoxide dismutase and catalase activity also suffered some significant decreases in the extract-treated rats. In addition, the toxicity results showed no mortality in acute and subacute evaluation. However, behavioural disturbance in Y maze and elevated plus maze tests were observed in all animals receiving acute toxicity doses (2400 and 3000 mg/kg b.w.). Likewise, for the subacute study, there was a body weight lost, biochemical and haematological changes in the extract treated groups. In conclusion, this study suggests that D. innoxia leaves aqueous extracts do not show any anti-amnesic effect on scopolamine-induced memory impairment rats. It could be considered low toxic up to the dose level of 3000 mg/kg b.w. in oral acute use and at the dose level up to 400 mg/kg b.w. in oral subacute use. These results could be of interest for the further use of this extract in traditional or clinical medicine. Rezumat Plantele tradiționale sunt utilizate foarte frecvent în medicina alternativă pentru tratamentul multor patologii. Cu toate acestea, există o serie de discuții cu privire la siguranța utilizării acestora. Prezentul studiu își propune să evalueze efectul anti-amnezic al extractului apos de frunze de Datura innoxia și posibilul impact toxic al utilizării sale. Astfel, au fost evaluate posibilele efecte protectoare ale extractului asupra sistemului nervos central, precum și efectele sale toxice, folosind modele de șobolani Wistar și respectiv șoareci NMRI. Rezultatele au demonstrat absența efectului protector al extractului în testele de comportament, precum și asupra nivelurilor de acetil colinesterază, superoxid-dismutază și catalază. Activitatea superoxiddismutazei și catalazei au prezentat scăderi semnificative la șobolanii tratați. În plus, rezultatele testelor de toxicitate nu au demonstrat mortalitate în evaluare acută și subacută. Cu toate acestea, au fost observate tulburări de comportament în testul labirintului la toate animalele care au primit doze toxice (2400 și 3000 mg/kg corp). De asemenea, pentru studiul subacut, s-a înregistrat o pierdere în greutatea corporală, precum și modificări biochimice și hematologice în grupele tratate cu extract. În concluzie, acest studiu sugerează că extractul apos de frunze de D. innoxia nu are efect anti-amnezic asupra șobolanilor cu deficiențe de memorie induse ...

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Chemical Constituents, Neuroprotective and Antioxidant Potential of Klasea centauroides Leaves

Razuvaeva

Markova²,

Торопова³

et al. 2023

Applied Sciences

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Owing to progressive aging in the population, there is an increase in patients with cognitive impairment. For the prevention of dementia, the use of plant remedies is relevant. Of particular interest is Klasea centauroides (L.) Cass. (Serratula centauroides L., Asteraceae), which has significant natural reserves, contains a wide range of biologically active substances, and is used in folk medicine to treat nervous system diseases. This study aimed to estimate the neuroprotective, energy-protective, and antioxidant effects of K. centauroides extract in cholinergic deficiency caused by long-term scopolamine administration. It has been established that K. centauroides extract accelerates passive avoidance-conditioned reflex development and ensures its preservation over a longer time period under cholinergic deficiency conditions. The K. centauroides extract increases the resistance of brain tissues to the toxic effects of scopolamine, reducing the number of neuron regressive forms in the cerebral cortex and hippocampus. The K. centauroides extract enhances the predominance of aerobic glycolysis over anaerobic glycolysis and enhances the NADH-dehydrogenase and succinate-dehydrogenase complexes activity, thus promoting more intensive ATP synthesis against this background, the introduction of scopolamine. The use of K. centauroides extracts reduces the malonic dialdehyde (MDA) content in the brain structures and increases the catalase (CAT) and antioxidant system glutathione unit activities.

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Phenolic Compounds of Serratula Centauroides and Anxiolytic Effect

Cited by 4 publications

References 17 publications

Rhaponticum uniflorum and Serratula centauroides Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress

Rhaponticum uniflorum and Serratula centauroides Extracts Attenuate Emotional Injury in Acute and Chronic Emotional Stress

Brain Protection and Anti-Amnesic Effects Assessment of Datura Innoxia Mill. Aqueous Extracts

Chemical Constituents, Neuroprotective and Antioxidant Potential of Klasea centauroides Leaves

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