Phenolic Compounds Profile from Algerian Pomegranate Fruit Extract (Punica Granatum L.) by UPLC-DAD-ESI-MS

Zeghad, Nadia; Abassi, Ejaz Ahmed; Belkhiri, Abdelmalik; Demeyer, Kristiaan; Heyden, Yvan Vander

doi:10.1007/s42250-022-00409-1

Cited by 4 publications

(5 citation statements)

References 40 publications

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“…Our results have indicated that hydroalcoholic fruits peels extract of pomegranate (Punica granatum L.) has significantly (p˂0.0001) a higher TPC, TF and TFL values than fruits peels extract of Opuntia ficus indica L. The highest TPC, TF and TFL were obtained for hydroalcoholic fruits peels extract of pomegranate (Punica granatum L.) (590.07±13.58 mg/g GAE g 1-, 227.85± 46.48 mg/g QE g 1-, 91.57±5.79 mg/g QE g 1-, respectively) (Table 1). The current results show that main compounds are flavonoids and flavonol derivatives in the extracts of pomegranate fruits peels, which is in agreement with findings of studies performed previously [24][25][26] . It is further reported that level of phenolic compounds is changed with fruits parts and their cultivars as discussed by Sushil Belkacem et al 22 ; Linlin et al 23 and Kumar Middha et al 27 .The peel extract contained the highest level of total phenolic content that were obtained in all cultivars.…”

Section: Antioxidant Activitysupporting

confidence: 93%

Exploring the potential use of pomegranate (Punica granatum L.) and prickly pear (Opuntia ficus indica L.) peels as sources of cosmaceutical sunscreen agent for their antioxidant and photoprotective properties

Zeghad,

Ahmed,

Khan

et al. 2023

Pharm Sci Asia

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Nowadays, consumer's demand for natural sources-derived sunscreen products, to get photoprotection from harmful ultraviolet radiations is forcing cosmetic industry to develop such breakthrough formulations by incorporating antioxidants as active phytochemical ingredients. Plant extracts are currently being focused for the purpose, but bio-wastes including fruit peels remain yet unexplored and consequently, underutilized. The present study is aimed to evaluate the photoprotective and antioxidant potential of pomegranate (Punica granatum L.) and prickly pear (Opuntia ficus indica L.) fruit peels extracts and to valorize their potential use as sources in cosmeceutical sunscreen agents. The selected extracts were estimated for antioxidant activity by DPPH, ABTS, FRAP, CUPRAC and GOR methods and their antioxidant properties were correlated to reference standards (BHT and BHA). The sun protection factor (SPF) was used to assess their photoprotective effect (SPF) in vitro. It was found that hydroalcoholic peel fruit pomegranate (Punica granatum L.) extract possessed highest antioxidant activities significantly (p˂0.0001) in all the methods compared to peel fruit prickly pear (Opuntia ficus indica L.) extract, possessing rich source of antioxidants. Hydroalcoholic peel fruit pomegranate (Punica granatum L.) extract, also presented the highest phenolic content. It was found that antioxidant activity was due to phenolic compounds containing flavonoids and confer photoprotection. The highest SPF was also related to hydroalcoholic peel fruit pomegranate (Punica granatum L.) extract with highest levels of protection against ultraviolet light with sun protection values ranging at 44.402±0.438. It is rational to apply these active compounds from waste to sunscreens, in order to increase UV protection.

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Section: Antioxidant Activitysupporting

confidence: 93%

Exploring the potential use of pomegranate (Punica granatum L.) and prickly pear (Opuntia ficus indica L.) peels as sources of cosmaceutical sunscreen agent for their antioxidant and photoprotective properties

Zeghad,

Ahmed,

Khan

et al. 2023

Pharm Sci Asia

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“…Moreover, the preliminary phytochemical investigation on the fruit extracts of V. vinifera and P. granatum demonstrated that V. vinifera and P. granatum are a rich source of phenolic compounds, including gallic acid, catechins and resveratrol, as well as a wide range of procyanidins [9,19] which can accelerate wound healing. The presence of these metabolites, which are reported to play a critical role in the wound healing process by increasing the rate of wound contraction, lowering the period of epithelialization and preventing secondary bacterial infections that would induce complex and delayed wound healing, could explain the wound healing activity [29,30].…”

Section: Discussionmentioning

confidence: 99%

“…The lyophilized edible fruits were subjected to extraction by maceration assisted by ultrasound [9,19] in an ultrasonic bath (Fisher scientific fb 15046, Leicestershire, England) (>20 kHz in frequency) for 30 min at room temperature using methanol/water (70/30) as solvent in a solid/liquid ratio of 25 g/500 ml, followed by maceration in a magnetic stirrer for 24h. The remaining vegetal material was extracted again twice under identical conditions.…”

Section: Extraction Processmentioning

confidence: 99%

In vivo healing potential of Vitis Vinifera L. and Punica Granatum L. fruit extracts in excision and burn models in rabbits

Zeghad

Ahmed

Zakryya

et al. 2023

Current Issues in Pharmacy and Medical Sciences

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Aim. The present study was carried out to evaluate the wound healing potential of crude Hydroalcoholic fruit extracts of Grape (Vitis vinifera L.) and Pomegranate (Punica granatum L.) in experimental animals. Material and methods. Extracts were formulated as ointments (250 mg), and their wound healing properties were determined by using two models: i.e. excision and burn models, in rabbits. Wound healing potential was assessed by measuring rate of wound contraction (percentage wound contraction) and the epithelialization period. Tukey test (HSD) test was used to analyze the obtained results. The value of p <0.05 was considered as a level of significance. The reference standard was wadded Cicatryl® ointment. Results. The result showed that crude fruit extracts of Vitis vinifera L. and Punica granatum L. exhibited a significant (p <0.0001) rate of wound contraction and significant (p<0.0001) decrease in the period of epithelialization compared to the control (untreated) group in both the models studied. Conclusion. Our results suggest that topical treatment of fruit extracts of Vitis vinifera L. and Punica granatum L. accelerate wound healing activity, thus our study supports their traditional use. Both extracts can be used as a potential source of wound healing therapeutics.

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“…21 A recent study on Algerian pomegranate fruit identified more than 50 phenolic compounds, including many substances that were detected for the first time in the pomegranate fruit extract. 22 Akhtar et al 23 mentioned that the properties of pomegranate are not limited to the edible part of the fruit but also to the non-edible part such as peels, even though they are considered waste. According to previous reports, the pomegranate peels are rich in chemical compounds including phenolic acids (e.g.…”

Section: Introductionmentioning

confidence: 99%

In vitro Antioxidant, anti-Alzheimer and Antibacterial Activities of Ethyl acetate and n-Butanol Fractions of Punica granatum Peel from Algeria

2023

TJNPR

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Polyphenols are secondary plant metabolites and are naturally present in almost all plant materials. 7 Alzheimer's disease is the most common cause of dementia in the elderly population. Clinically, AD is characterized initially by mild memory impairment that declines progressively to the ultimate loss of mental and physical skills. 8 Acetylcholine (ACH) is a signaling molecule in neurotransmission; one of the few therapeutic approaches for AD is cholinesterase inhibitors. By inhibiting the activity of the enzymes acetylcholinesterase and butyrylcholinesterase, which are involved in acetylcholine hydrolysis, ACH levels at synapses can be increased. 9 Plants are estimated to be a potential source of novel cholinesterase inhibitors. 10 Microorganisms are ubiquitous and can cause huge health problems in humans. 11 Staphylococcus aureus is considered one of the most common sources of food borne diseases, while Bacillus cereus, Escherichia coli, and Pseudomonas aeruginosa produce toxins and other metabolites that induce human gastroenteritis diseases. 12 The pathogens can build resistance against antibiotics, 13,14 furthermore, synthetic antibiotic residues have been polluting the environment and ecosystem survival. 15 Plants are non toxic or with low toxicity, 16 they are regarded as a valuable source of naturally antimicrobial agents. 17

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Phenolic Compounds Profile from Algerian Pomegranate Fruit Extract (Punica Granatum L.) by UPLC-DAD-ESI-MS

Abstract: with details of the nature of the infringement. We will investigate the claim and if justified, we will take the appropriate steps.

Cited by 4 publications

References 40 publications

Exploring the potential use of pomegranate (Punica granatum L.) and prickly pear (Opuntia ficus indica L.) peels as sources of cosmaceutical sunscreen agent for their antioxidant and photoprotective properties

Exploring the potential use of pomegranate (Punica granatum L.) and prickly pear (Opuntia ficus indica L.) peels as sources of cosmaceutical sunscreen agent for their antioxidant and photoprotective properties

In vivo healing potential of Vitis Vinifera L. and Punica Granatum L. fruit extracts in excision and burn models in rabbits

In vitro Antioxidant, anti-Alzheimer and Antibacterial Activities of Ethyl acetate and n-Butanol Fractions of Punica granatum Peel from Algeria

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