Phenolic Constituents and Their Anti-inflammatory Activity from<i>Echinochloa utilis</i>Grains

Nguyen, Duc Hung; Zhao, Bing; Le, Duc Dat; Kim, Ki Yun; Kim, Young Ho; Yoon, Young Ho; Ko, Jee Youn; Woo, Koan Sik; Woo, Mi Hee

doi:10.20307/nps.2016.22.2.140

Cited by 16 publications

(9 citation statements)

References 23 publications

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“…The 13 C NMR (101 MHz, DMSO-d 6 ) δ 168.42 (COOH), 160.05 (C-4), 144.64 (C-7), 130.53 (C-2, C-6), 125.75 (C-1), 116.22 (C-3, C-5), and 115.80 (C-8) ( Supplementary Figure S1 ). The NMR and ESI-MS results are entirely similar to those in the literature [ 35 ].…”

Section: Resultssupporting

confidence: 83%

Salinity Treatments Promote the Accumulations of Momilactones and Phenolic Compounds in Germinated Brown Rice

Hasan

Quan

Anh

et al. 2023

Foods

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This is the first investigation, conducted in a completely randomized design (CRD), to determine the effects of different salinity levels (75 and 150 mM) and germination periods (3, 4, and 5 days) on momilactone and phenolic accumulations in germinated brown rice (GBR) var. Koshihikari. Particularly, the identification of bioactive compounds was confirmed using electrospray ionization-mass spectrometry (ESI-MS) and nuclear magnetic resonance (NMR) spectroscopy (1H and 13C). Momilactone A (MA) and momilactone B (MB) amounts were determined by ultra-performance liquid chromatography–electrospray ionization-mass spectrometry (UPLC–ESI-MS), whereas other compounds were quantified by spectrophotometry and high-performance liquid chromatography (HPLC). Accordingly, GBR under B2 treatment (75 mM salinity for 4 days) showed the greatest total phenolic and flavonoid contents (14.50 mg gallic acid and 11.06 mg rutin equivalents, respectively, per g dry weight). GBR treated with B2 also accumulated the highest quantities of MA, MB, ρ-coumaric, ferulic, cinnamic, salicylic acids, and tricin (18.94, 41.00, 93.77, 139.03, 46.05, 596.26, and 107.63 µg/g DW, respectively), which were consistent with the strongest antiradical activities in DPPH and ABTS assays (IC50 = 1.58 and 1.78 mg/mL, respectively). These findings have implications for promoting the value of GBR consumption and rice-based products that benefit human health.

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Section: Resultssupporting

confidence: 83%

Salinity Treatments Promote the Accumulations of Momilactones and Phenolic Compounds in Germinated Brown Rice

Hasan

Quan

Anh

et al. 2023

Foods

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“…1 Luteolin (2) Isolated as an amorphous yellow solid (3.2 mg, 0.32%). Spectral characteristics matched previously reported data [27]. 1 Apigenin (3) Isolated as an amorphous yellow solid (7.7 mg, 0.76%).…”

Section: Purification Of Z Muelleri Aerial Extractsupporting

confidence: 82%

The In Vitro Antioxidant and Anti-Inflammatory Activities of Selected Australian Seagrasses

Perry,

Curic,

Scott

et al. 2024

Life

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Recent studies have shown that seagrasses could possess potential applications in the treatment of inflammatory disorders. Five seagrass species (Zostera muelleri, Halodule uninervis, Cymodocea rotundata, Syringodium isoetifolium, and Thalassia hemprichii) from the Great Barrier Reef (QLD, Australia) were thus collected, and their preliminary antioxidant and anti-inflammatory activities were evaluated. From the acetone extracts of five seagrass species subjected to 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging antioxidant assay, the extract of Z. muelleri had the highest activity (half minimal concentration of inhibition (IC50) = 138 µg/mL), with the aerial parts (IC50 = 119 µg/mL) possessing significantly higher antioxidant activity than the roots (IC50 ≥ 500 µg/mL). A human peripheral blood mononuclear cells (PBMCs) assay with bacterial lipopolysaccharide (LPS) activation and LEGENDplex cytokine analysis showed that the aerial extract of Z. muelleri significantly reduced the levels of inflammatory cytokines tumour necrosis factor alpha (TNF-α), interleukin (IL)-1β, and IL-6 by 29%, 74%, and 90%, respectively, relative to the LPS treatment group. The aerial extract was thus fractionated with methanol (MeOH) and hexane fraction, and purification of the MeOH fraction by HPLC led to the isolation of 4-hydroxybenzoic acid (1), luteolin (2), and apigenin (3) as its major constituents. These compounds have been previously shown to reduce levels of TNF-α, IL-1β, and IL-6 and represent some of the major bioactive components of Z. muelleri aerial parts. This investigation represents the first study of the antioxidant and anti-inflammatory properties of Z. muelleri and the first isolation of small molecules from this species. These results highlight the potential for using seagrasses in treating inflammation and the need for further investigation.

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“…The 13 C NMR showed one aldehydic carbon at δ 191.4 ppm, one oxygenated carbon signal at δ 163.2 ppm and four olefins at δ 132.4 and 115.8 ppm. These spectroscopic data are found to be identical with the spectroscopic data of 4hydroxybenzaldehyde [14].…”

Section: Secondary Metabolites From Thysanolaena Maximasupporting

confidence: 72%

Cytotoxic metabolites from Thysanolaena maxima Roxb. available in Bangladesh

et al. 2020

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Background Thysanolaena maxima (Roxb.) Kuntze, a perennial grass plant, is usually distributed in hilly regions of the Indian Subcontinent. Different parts of T. maxima have been used as herbal medicine by traditional healers of this region. In this present study, T. maxima plant extract has been screened for examination of its secondary metabolite content with their probable cytotoxic activity. Methods Secondary metabolites of the crude T. maxima plant extract were isolated by different chromatographic methods. The structures were elucidated by spectroscopic data (1H NMR, 13C NMR) as well as comparison with available literature sources. Antiradical activity by DPPH radical scavenging assay and antimicrobial activity by disc diffusion method of the fractions and cytotoxic activity by trypan blue exclusion method of the isolated compounds were also evaluated. Results Three phenolic compounds 4-hydroxybenzaldehyde (1), 4-hydroxycinnamic acid (2), 4-hydroxybenzoic acid (3) and two steroids stigmast-4-en-3-one (4) and β-stigmasterol (5) were isolated from the aerial part of T. maxima. Among the compounds 4-hydroxycinnamic acid, 4-hydroxybenzoic acid and stigmast-4-en-3-one exhibited notable cytotoxic activity against African Green Monkey Kidney Cell line (Vero cell). Conclusion Bioassay investigation of the isolated compounds and fractions suggested that T. maxima could be a potential source of bioactive secondary metabolites. Graphical abstract

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Phenolic Constituents and Their Anti-inflammatory Activity fromEchinochloa utilisGrains

Cited by 16 publications

References 23 publications

Salinity Treatments Promote the Accumulations of Momilactones and Phenolic Compounds in Germinated Brown Rice

Salinity Treatments Promote the Accumulations of Momilactones and Phenolic Compounds in Germinated Brown Rice

The In Vitro Antioxidant and Anti-Inflammatory Activities of Selected Australian Seagrasses

Cytotoxic metabolites from Thysanolaena maxima Roxb. available in Bangladesh

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